N6-methyladenosine-dependent primary microRNA-126 processing activated PI3K-AKT-mTOR pathway drove the development of pulmonary fibrosis induced by nanoscale carbon black particles in rats

Pulmonary toxicities from a 90-day chronic inhalation study with carbon black nanoparticles in rats related to the systemical immune effects

(2019) Chen Chu et al.   International Journal of Nanomedicine

Leptin promotes pulmonary fibrosis development by inhibiting autophagy via PI3K/Akt/mTOR pathway

(2018) Xianhua Gui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defining the criteria for intubation of the patient with thermal burns

(2018) Jenelle H. Badulak et al.   BURNS

Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

(2018) Liwen Wei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Transplantation of adipose-derived mesenchymal stem cells attenuates pulmonary fibrosis of silicosis via anti-inflammatory and anti-apoptosis effects in rats

(2018) Shangya Chen et al.   Stem Cell Research & Therapy

Regulation of microRNA function in animals

(2018) Luca F. R. Gebert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CORP: Measurement of lung function in small animals

(2017) Jason H.T. Bates   JOURNAL OF APPLIED PHYSIOLOGY

Acute in vitro and in vivo toxicity of a commercial grade boron nitride nanotube mixture

(2017) Vamsi K. Kodali et al.   Nanotoxicology

Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

(2017) Koustav Ganguly et al.   Particle and Fibre Toxicology

Pulmonary Exposure to Carbon Black Nanoparticles Increases the Number of Antigen-Presenting Cells in Murine Lung

(2017) E. Koike et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Structure of Human DROSHA

(2016) S. Chul Kwon et al.   CELL

MicroRNA-126 Targeting PIK3R2 Inhibits NSCLC A549 Cell Proliferation, Migration, and Invasion by Regulation of PTEN/PI3K/AKT Pathway

(2016) Lei Song et al.   Clinical Lung Cancer

METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing

(2016) Jin-zhao Ma et al.   HEPATOLOGY

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

(2016) Qiuyun Wu et al.   Scientific Reports

Functional Anatomy of the Human Microprocessor

(2015) Tuan Anh Nguyen et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis

(2015) Xiaoming Ji et al.   Scientific Reports

Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts

(2014) Luai Huleihel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

(2014) Salik Hussain et al.   Particle and Fibre Toxicology

Reduced pulmonary function and increased pro-inflammatory cytokines in nanoscale carbon black-exposed workers

(2014) Rong Zhang et al.   Particle and Fibre Toxicology

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Nanotechnology: Toxicologic Pathology

(2013) Ann F. Hubbs et al.   TOXICOLOGIC PATHOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Rapamycin Inhibits the mTOR/p70S6K Pathway and Attenuates Cardiac Fibrosis in Adriamycin-induced Dilated Cardiomyopathy

(2012) Lei Liu et al.   THORACIC AND CARDIOVASCULAR SURGEON

Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure

(2012) Julie A. Bourdon et al.   TOXICOLOGY

Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

(2011) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Acute Respiratory Inflammation in Children and Black Carbon in Ambient Air before and during the 2008 Beijing Olympics

(2011) Weiwei Lin et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Carbon black nanoparticles enhance bleomycin-induced lung inflammatory and fibrotic changes in mice

(2011) Hirofumi Kamata et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Novel Role of Vimentin Filaments: Binding and Stabilization of Collagen mRNAs

(2011) A. A. Challa et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

(2010) Gang Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis

(2010) Eleonora Patsenker et al.   JOURNAL OF HEPATOLOGY

miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression

(2010) Irene K. Oglesby et al.   JOURNAL OF IMMUNOLOGY

The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation

(2010) Edward K. Geissler et al.   KIDNEY INTERNATIONAL

Expression and function of miRNA in postoperative radiotherapy sensitive and resistant patients of non-small cell lung cancer

(2010) Xiao-Chun Wang et al.   LUNG CANCER

Comparative Proteomics and Pulmonary Toxicity of Instilled Single-Walled Carbon Nanotubes, Crocidolite Asbestos, and Ultrafine Carbon Black in Mice

(2010) Justin G. Teeguarden et al.   TOXICOLOGICAL SCIENCES

Emerging Concepts in the Pathogenesis of Lung Fibrosis

(2009) William D. Hardie et al.   AMERICAN JOURNAL OF PATHOLOGY

Bacterial Lipopolysaccharide Enhances PDGF Signaling and Pulmonary Fibrosis in Rats Exposed to Carbon Nanotubes

(2009) Mark F. Cesta et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Dust content of lungs and its relationships to pathology, radiology and occupational exposure in Ontario hardrock miners

(2008) Dave K. Verma et al.   AMERICAN JOURNAL OF INDUSTRIAL MEDICINE

Deducing in Vivo Toxicity of Combustion-Derived Nanoparticles from a Cell-Free Oxidative Potency Assay and Metabolic Activation of Organic Compounds

(2008) Tobias Stoeger et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers

(2008) Chunguang Guo et al.   GENES CHROMOSOMES & CANCER

Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

(2008) Hong Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE