The Inhibitory Effect of (−)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity

A prodrug of green tea polyphenol (–)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer

(2018) Jianzhang Wang et al.   CANCER LETTERS

(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer

(2018) Joan Crous-Masó et al.   MOLECULES

In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

(2018) Koichi Saeki et al.   MOLECULES

Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques

(2018) J. B. Liu et al.   Mucosal Immunology

Cancer epigenetics: Moving forward

(2018) Angela Nebbioso et al.   PLoS Genetics

Bioinformatics analysis of microarray profiling identifies the mechanism of focal adhesion kinase signalling pathway in proliferation and apoptosis of breast cancer cells modulated by green tea polyphenol epigallocatechin 3-gallate

(2018) Xiao Luo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Sulforaphane and Epigallocatechin Gallate Restore Estrogen Receptor Expression by Modulating Epigenetic Events in the Breast Cancer Cell Line MDA-MB-231: A Systematic Review and Meta-Analysis

(2017) Vincenza Gianfredi et al.   Journal of Nutrigenetics and Nutrigenomics

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9

(2017) Ke-Wang Luo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

(−)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway

(2017) Yue Chen et al.   Nutrients

Combinatorial bioactive botanicals re-sensitize tamoxifen treatment in ER-negative breast cancer via epigenetic reactivation of ERα expression

(2017) Yuanyuan Li et al.   Scientific Reports

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

(2016) R. Pathania et al.   CANCER RESEARCH

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

(2016) Prasad R. Dandawate et al.   SEMINARS IN CANCER BIOLOGY

Neuroprotective Activity of (-)-Epigallocatechin Gallate against Lipopolysaccharide-Mediated Cytotoxicity

(2016) Jin-Biao Liu et al.   Journal of Immunology Research

Tumor-Homing Cell-Penetrating Peptide Linked to Colloidal Mesoporous Silica Encapsulated (-)-Epigallocatechin-3-gallate as Drug Delivery System for Breast Cancer Therapy in Vivo

(2015) Jie Ding et al.   ACS Applied Materials & Interfaces

Potentiation of growth inhibition and epigenetic modulation by combination of green tea polyphenol and 5-aza-2′-deoxycytidine in human breast cancer cells

(2015) Tulika Tyagi et al.   BREAST CANCER RESEARCH AND TREATMENT

Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors

(2015) Xiaofei Chen et al.   Epigenetics

EGCG Inhibits Proliferation, Invasiveness and Tumor Growth by Up-Regulation of Adhesion Molecules, Suppression of Gelatinases Activity, and Induction of Apoptosis in Nasopharyngeal Carcinoma Cells

(2015) Chih-Yeu Fang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

15q12 Variants, Sputum Gene Promoter Hypermethylation, and Lung Cancer Risk: A GWAS in Smokers

(2015) Shuguang Leng et al.   JNCI-Journal of the National Cancer Institute

Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs

(2015) S. Tsukamoto et al.   MOLECULAR CANCER THERAPEUTICS

Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1

(2015) Kewei Zhu et al.   TUMOR BIOLOGY

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

(2015) Derek A. Martin et al.   Food & Function

15q12 Variants, Sputum Gene Promoter Hypermethylation, and Lung Cancer Risk: A GWAS in Smokers

(2015) Shuguang Leng et al.   JNCI-Journal of the National Cancer Institute

DNA Methyltransferase Inhibitor Zebularine Induces Human Cholangiocarcinoma Cell Death through Alteration of DNA Methylation Status

(2015) Kazuaki Nakamura et al.   PLoS One

Characterizing DNA methylation alterations from The Cancer Genome Atlas

(2014) Daniel J. Weisenberger   JOURNAL OF CLINICAL INVESTIGATION

Clinical development of demethylating agents in hematology

(2014) Shyamala C. Navada et al.   JOURNAL OF CLINICAL INVESTIGATION

Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo

(2014) Imtiaz A. Siddiqui et al.   Nanomedicine-Nanotechnology Biology and Medicine

(-)-Epigallocatechin-3-gallate inhibits nasopharyngeal cancer stem cell self-renewal and migration and reverses the epithelial–mesenchymal transition via NF-κB p65 inactivation

(2014) Ya-Jun Li et al.   TUMOR BIOLOGY

Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma

(2013) M. F. Kaiser et al.   BLOOD

Interplay between the Cancer Genome and Epigenome

(2013) Hui Shen et al.   CELL

Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN

(2013) Maciej Skrzypczak et al.   GYNECOLOGICAL ENDOCRINOLOGY

Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition

(2013) Y.-C. Lin et al.   JOURNAL OF CELL SCIENCE

Epigallocatechin-3-Gallate (EGCG) Inhibits Cell Proliferation and Migratory Behaviour of Triple Negative Breast Cancer Cells

(2013) Cornelia Braicu et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in Colitis Models

(2013) Helieh S. Oz et al.   Frontiers in Immunology

Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model

(2012) Man-Chin Chen et al.   Innate Immunity

Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice

(2012) Kouji Banno et al.   Epigenomics

Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea

(2012) Guang-Jian Du et al.   Nutrients

Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome

(2011) Shabana I. Khan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Domain and Functional Analysis of a Novel Breast Tumor Suppressor Protein, SCUBE2

(2011) Yuh-Charn Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Methyltransferase Inhibitor, Zebularine, Delays Tumor Growth and Induces Apoptosis in a Genetically Engineered Mouse Model of Breast Cancer

(2011) M. Chen et al.   MOLECULAR CANCER THERAPEUTICS

SCUBE2 Suppresses Breast Tumor Cell Proliferation and Confers a Favorable Prognosis in Invasive Breast Cancer

(2009) C.-J. Cheng et al.   CANCER RESEARCH