Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Models of human core transcriptional regulatory circuitries

(2016) Violaine Saint-André et al.   GENOME RESEARCH

Human C-terminally truncated ERα variants resulting from the use of alternative exons in the ligand-binding domain

(2016) Yujiro Hattori et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Tissue-Specific Expression of Estrogen Receptor 1 Is Regulated by DNA Methylation in a T-DMR

(2016) Ryo Maekawa et al.   MOLECULAR ENDOCRINOLOGY

CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing

(2016) Danxin Wang et al.   Pharmacogenetics and Genomics

Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells

(2015) Prathap Kumar S. Mahalingaiah et al.   BREAST CANCER RESEARCH AND TREATMENT

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis

(2015) Xiang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Cytochrome P450 1 family and cancers

(2015) Ryeo-Eun Go et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

The “busy life” of unliganded estrogen receptors

(2015) Claudia Stellato et al.   PROTEOMICS

Functional Gene Variants of CYP3A4

(2014) A N Werk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Functional characterization of CYP2D6 enhancer polymorphisms

(2014) Danxin Wang et al.   HUMAN MOLECULAR GENETICS

Generalized Sobol sensitivity indices for dependent variables: numerical methods

(2014) G. Chastaing et al.   JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION

Genome-wide activity of unliganded estrogen receptor-α in breast cancer cells

(2014) Livia Caizzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen receptor 1 gene as a tumor suppressor gene in hepatocellular carcinoma detected by triple-combination array analysis

(2013) MITSUHIRO HISHIDA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Transcriptomic and epigenetic changes in early liver steatosis associated to obesity: Effect of dietary methyl donor supplementation

(2013) Paul Cordero et al.   MOLECULAR GENETICS AND METABOLISM

PPARA: A Novel Genetic Determinant of CYP3A4 In Vitro and In Vivo

(2012) Kathrin Klein et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of folate deficiency on promoter methylation and gene expression of Esr1, Cdh1 and Pgr, and its influence on endometrial receptivity and embryo implantation

(2012) Rufei Gao et al.   HUMAN REPRODUCTION

Generalized Hoeffding-Sobol decomposition for dependent variables - application to sensitivity analysis

(2012) Gaelle Chastaing et al.   Electronic Journal of Statistics

Progesterone Receptor Membrane Component 1 Modulates Human Cytochrome P450 Activities in an Isoform-Dependent Manner

(2011) S. Oda et al.   DRUG METABOLISM AND DISPOSITION

Genetic epidemiology of induced CYP3A4 activity

(2011) Nilufer Rahmioglu et al.   Pharmacogenetics and Genomics

Variance-based sensitivity indices for models with dependent inputs

(2011) Thierry A. Mara et al.   RELIABILITY ENGINEERING & SYSTEM SAFETY

Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding

(2010) Monica A. Istrate et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

(2010) X. Yang et al.   GENOME RESEARCH

Global Sensitivity Analysis for Systems with Independent and/or Correlated Inputs

(2010) Genyuan Li et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Sorafenib Inhibits STAT3 Activation to Enhance TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells

(2010) S. Huang et al.   MOLECULAR CANCER THERAPEUTICS

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

(2010) D Wang et al.   PHARMACOGENOMICS JOURNAL

Modulation of androgen and estrogen receptor expression by antiepileptic drugs and steroids in hippocampus of patients with temporal lobe epilepsy

(2009) Nina Killer et al.   EPILEPSIA

Genetic Predictors of Interindividual Variability in Hepatic CYP3A4 Expression

(2009) V. Lamba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent

(2008) Jill C. Mwenifumbo et al.   HUMAN MUTATION

PGRMC1 (progesterone receptor membrane component 1): A targetable protein with multiple functions in steroid signaling, P450 activation and drug binding

(2008) Hannah J. Rohe et al.   PHARMACOLOGY & THERAPEUTICS

Uncertainty and sensitivity analysis for models with correlated parameters

(2007) Chonggang Xu et al.   RELIABILITY ENGINEERING & SYSTEM SAFETY