IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway

IRX5 promotes NF-κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma

(2018) Liyuan Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression

(2017) Jie Ding et al.   Cell Death & Disease

Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase transition in vascular smooth muscle cells by CDK2-dependent activation

(2016) Dong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Downregulation of miR-377 contributes to IRX3 deregulation in hepatocellular carcinoma

(2016) PEI WANG et al.   ONCOLOGY REPORTS

Increased expression of the long noncoding RNA CRNDE-h indicates a poor prognosis in colorectal cancer, and is positively correlated with IRX5 mRNA expression

(2016) Chuan-xin Wang et al.   OncoTargets and Therapy

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Scrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory context

(2015) Mathias Rask-Andersen et al.   HUMAN GENETICS

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling

(2015) Jinchang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner

(2015) TIELONG LIU et al.   Molecular Medicine Reports

An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases

(2015) Weining Wang et al.   ORAL ONCOLOGY

Cancer treatment and survivorship statistics, 2014

(2014) Carol E. DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling

(2014) Danyi Li et al.   DEVELOPMENTAL CELL

Iro/IRX transcription factors negatively regulate Dpp/TGF-  pathway activity during intestinal tumorigenesis

(2014) O. Martorell et al.   EMBO REPORTS

Effect of Flexible Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality

(2014) Øyvind Holme et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Proangiogenic Effect of Iroquois Homeobox Transcription Factor Irx3 in Human Microvascular Endothelial Cells

(2014) Kisha Scarlett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway

(2014) TIELONG LIU et al.   Molecular Medicine Reports

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer

(2014) Paulo Rodrigues et al.   Nature Communications

Chromatin-Bound IκBα Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer

(2013) María Carmen Mulero et al.   CANCER CELL

Long-Term Colorectal-Cancer Incidence and Mortality after Lower Endoscopy

(2013) Reiko Nishihara et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo

(2013) Yoshinori Kagawa et al.   PLoS One

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

(2012) N. Gaborit et al.   DEVELOPMENT

Microcystin-LR Promotes Melanoma Cell Invasion and Enhances Matrix Metalloproteinase-2/-9 Expression Mediated by NF-κB Activation

(2012) Xu-Xiang Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility

(2012) Hai Ha Nguyen et al.   HUMAN MOLECULAR GENETICS

Developmental aspects of cardiac arrhythmogenesis

(2011) A. V. Postma et al.   CARDIOVASCULAR RESEARCH

Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells

(2010) Seiji Adachi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma

(2010) X Guo et al.   ONCOGENE

Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters

(2009) Hai-bo Wang et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Molecular Basis of Colorectal Cancer

(2009) Sanford D. Markowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequently Methylated Tumor Suppressor Genes in Head and Neck Squamous Cell Carcinoma

(2008) K. L. Bennett et al.   CANCER RESEARCH