Article
Medicine, General & Internal
Zainab Aziz, Sophie Wagner, Alice Agyekum, Yoanna S. Pumpalova, Matthew Prest, Francesca Lim, Sheila Rustgi, Fay Kastrinos, William M. Grady, Chin Hur
Summary: Despite recommendations for universal screening, adherence to colorectal cancer screening in the US is low. This study evaluated the cost-effectiveness of liquid biopsy for colorectal cancer screening and found that colonoscopy was the most cost-effective strategy, while liquid biopsy was not cost-effective at its current cost and screening performance.
Review
Biology
Xueqi Hu, Dongdong Zhang, Zheng Zeng, Linjie Huang, Xiahui Lin, Shanni Hong
Summary: Aptamers, single-stranded DNA or RNA oligomers with high specificity and binding affinity, have shown great potential in cancer diagnostics and treatments. They can bind to cancer biomarkers and serve as molecular probes for detection.
Article
Medicine, Research & Experimental
Huixian Zhang, Lanfang Li, Lei Feng, Zhen Zhou, Xin Zhang, Jianbo Feng, Qiao Liu
Summary: This study examined the cost-effectiveness of first-line toripalimab plus chemotherapy for Chinese patients with advanced non-small cell lung cancer. The results showed that this strategy was cost-effective for the overall patient population and offered better effectiveness and lower costs in certain subgroups based on pathology and biomarkers.
ADVANCES IN THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Stavros P. Papadakos, Nikolaos Dedes, Alexandros Pergaris, Maria Gazouli, Stamatios Theocharis
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is a major cause of cancer death worldwide, and its mortality remains unchanged despite significant advancements in diagnostics and treatment. Exosomes have been found to play important roles in carcinogenesis, metastasis, and immune response. Investigating the applications of exosomes in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer is of great significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Samia Asif, Benjamin A. Teply
Summary: Prostate cancer is a leading cause of cancer-related death among males, and despite many available treatments, advanced prostate cancer remains incurable and fatal. Personalized treatment and the use of biomarkers for decision-making are crucial for optimizing clinical outcomes in managing advanced prostate cancer.
Review
Oncology
Homan Kang, Min-Woong Kang, Satoshi Kashiwagi, Hak Soo Choi
Summary: Cancer immunotherapy is a powerful anticancer therapy, but the interaction between tumors and the immune system is complex and not well understood. Optical fluorescence imaging is a technique that allows for visualizing immune cells and monitoring immune response during immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
R. Casolino, C. Braconi, G. Malleo, S. Paiella, C. Bassi, M. Milella, S. B. Dreyer, F. E. M. Froeling, D. K. Chang, A. Biankin, T. Golan
Summary: This review emphasizes the importance of personalized therapeutic approaches based on genomic factors in the preoperative setting for pancreatic cancer to reduce mortality rates.
ANNALS OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Mizan Kiros Mirutse, Michael Tekle Palm, Mieraf Taddesse Tolla, Solomon Tessema Memirie, Eden Shiferaw Kefyalew, Daniel F. Hailu, Ole Norheim, Muktar Beshir Ahmed
Summary: Despite the recent interest in expanding pediatric oncology units in Ethiopia, little is known about the cost of running such units and treating childhood cancers. This study collected cost data for a pediatric oncology unit and other departments in Tikur Anbessa Specialized Hospital from July 2018 to July 2019, and estimated the total annual cost of running the unit. The results showed that running a pediatric oncology unit in Ethiopia is likely to be affordable.
Review
Pharmacology & Pharmacy
Salome Araujo-Abad, Miguel Saceda, Camino de Juan Romero
Summary: Extracellular vesicles (EVs), especially exosomes, are cellular communication tools produced by almost all cell types, and they can be used as biomarkers and drug delivery vehicles in diseases such as cancer, showing promising results in clinical trials.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Medicine, Research & Experimental
Kanghong Xu, Chengpeng Zhang, Tiantian Du, Abakundana Nsenga Ariston Gabriel, Xue Wang, Xiaomeng Li, Li Sun, Nan Wang, Xinquan Jiang, Yi Zhang
Summary: Lung cancer has the highest incidence and mortality rates worldwide, lacking early diagnostic biomarkers. Exosomes, as a mode of intercellular communication, play a role in regulating physiological processes in lung cancer by delivering various biomolecules. Studying the role of exosomes in diagnosing and treating lung cancer is crucial for improving treatment outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Virinder Kaur Sarhadi, Gemma Armengol
Summary: Molecular cancer biomarkers are measurable molecular indicators that provide information about cancer risk, occurrence, and patient outcome. They can be detected in various samples using advanced detection technologies. Biomarkers have extensive clinical applications and can assist in decision-making and individualized targeted therapies.
Review
Oncology
Jacob J. Adashek, Filip Janku, Razelle Kurzrock
Summary: Circulating tumor DNA (ctDNA) is an important advance in the diagnostic and surveillance toolbox for oncologists, allowing detection of microscopic levels of cancer tissue before, during, or after treatment. The advantages of ctDNA over tissue DNA include non-invasiveness, reflection of DNA shedding from multiple metastatic sites, and easy tracking of dynamic changes during therapy.
Article
Medicine, General & Internal
Yen-Jung Chang, Jing-Yang Huang, Ching-Hsiung Lin, Bing-Yen Wang
Summary: This study analyzed the prognostic factors of overall survival for 71,334 lung cancer patients in Taiwan from 2010 to 2016. It was found that age, gender, tumor type, and clinical staging were independent prognostic factors for lung cancer patients' survival outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Zhao Jing, Kai Chen, Ling Gong
Summary: Esophageal cancer is a common malignancy in China with high mortality, and understanding the role of exosomes in cancer progression can help improve prognosis. Exosomes are small vesicular structures that contain various components involved in cell-to-cell communication and material exchange, playing a role in cancer growth, metastasis, and angiogenesis. They also have potential as diagnostic and prognostic markers in cancer. This review discusses the significance of exosomes in esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression, as well as their utility as diagnostic and prognostic biomarkers and therapeutic tools.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Geriatrics & Gerontology
Wan-Yu Lin
Summary: This study investigated the biological age and associated lifestyle factors and genetic variants in Taiwan Biobank participants. The results showed that increased body mass index, smoking, and drinking were associated with accelerated biological aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)