Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway

Changes in Titin and Collagen Modulate Effects of Aerobic and Resistance Exercise on Diabetic Cardiac Function

(2019) Shunchang Li et al.   Journal of Cardiovascular Translational Research

Strength training attenuates post-infarct cardiac dysfunction and remodeling

(2019) Michael A. Garza et al.   Journal of Physiological Sciences

Serelaxin inhibits differentiation and fibrotic behaviors of cardiac fibroblasts by suppressing ALK-5/Smad2/3 signaling pathway

(2018) Xue-ping Wu et al.   EXPERIMENTAL CELL RESEARCH

A Crude 1-DNJ Extract from Home Made Bombyx Batryticatus Inhibits Diabetic Cardiomyopathy-Associated Fibrosis in db/db Mice and Reduces Protein N-Glycosylation Levels

(2018) Qing Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

Relaxin as a Therapeutic Target for the Cardiovascular Complications of Diabetes

(2018) Hooi Hooi Ng et al.   Frontiers in Pharmacology

Treadmill exercise alleviates diabetic cardiomyopathy by suppressing plasminogen activator inhibitor expression and enhancing eNOS in streptozotocin-induced male diabetic rats

(2018) Wang Chengji et al.   Endocrine Connections

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

(2018) Maayan Waldman et al.   Cardiovascular Diabetology

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

(2018) M. Joubert et al.   DIABETES & METABOLISM

H2O2 Signaling-Triggered PI3K Mediates Mitochondrial Protection to Participate in Early Cardioprotection by Exercise Preconditioning

(2018) Yang Yuan et al.   Oxidative Medicine and Cellular Longevity

Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function

(2017) Marwa Hassan Muhammad et al.   Journal of Physiological Sciences

Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels

(2017) Brian Bostick et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

(2017) Jinfan Tian et al.   Oxidative Medicine and Cellular Longevity

High-Intensity Exercise Reduces Cardiac Fibrosis and Hypertrophy but Does Not Restore the Nitroso-Redox Imbalance in Diabetic Cardiomyopathy

(2017) Ulises Novoa et al.   Oxidative Medicine and Cellular Longevity

Effects of weekly supervised exercise or physical activity counseling on fasting blood glucose in women diagnosed with gestational diabetes mellitus: A systematic review and meta-analysis of randomized trials

(2017) Roberta Bgeginski et al.   Journal of Diabetes

Role of miR-24, Furin, and Transforming Growth Factor-β1 Signal Pathway in Fibrosis After Cardiac Infarction

(2017) Zhufeng Chen et al.   MEDICAL SCIENCE MONITOR

Excessively low salt diet damages the heart through activation of cardiac (pro) renin receptor, renin-angiotensin-aldosterone, and sympatho-adrenal systems in spontaneously hypertensive rats

(2017) Chihiro Okamoto et al.   PLoS One

Resveratrol ameliorates myocardial fibrosis by inhibiting ROS/ERK/TGF-β/periostin pathway in STZ-induced diabetic mice

(2016) Han Wu et al.   BMC Cardiovascular Disorders

Reactive oxygen species and fibrosis: further evidence of a significant liaison

(2016) Kati Richter et al.   CELL AND TISSUE RESEARCH

Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1

(2016) Jin Ma et al.   Chinese Journal of Integrative Medicine

Diabetes and Complications: Cellular Signaling Pathways, Current Understanding and Targeted Therapies

(2016) Krishna A. Adeshara et al.   CURRENT DRUG TARGETS

LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice

(2016) Yasunori Suematsu et al.   EUROPEAN JOURNAL OF HEART FAILURE

Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy

(2016) Xin Guo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db/db mice

(2016) Sudhakar Veeranki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Origins of cardiac fibroblasts

(2016) Thomas Moore-Morris et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Elevated C-type natriuretic peptide elicits exercise preconditioning-induced cardioprotection against myocardial injury probably via the up-regulation of NPR-B

(2016) Jiao Lu et al.   Journal of Physiological Sciences

Cardioprotection of exercise preconditioning involving heat shock protein 70 and concurrent autophagy: a potential chaperone-assisted selective macroautophagy effect

(2016) Yang Yuan et al.   Journal of Physiological Sciences

Modulation of inflammatory and oxidative status by exercise attenuates cardiac morphofunctional remodeling in experimental Chagas cardiomyopathy

(2016) Rômulo D. Novaes et al.   LIFE SCIENCES

Swimming training attenuates the morphological reorganization of the myocardium and local inflammation in the left ventricle of growing rats with untreated experimental diabetes

(2016) Edson da Silva et al.   PATHOLOGY RESEARCH AND PRACTICE

The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2016) Kimberley L. Way et al.   Diabetes & Metabolism Journal

Exercise excess pressure and exercise-induced albuminuria in patients with type 2 diabetes mellitus

(2015) Rachel E. D. Climie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Elevated expression of periostin in diabetic cardiomyopathy and the effect of valsartan

(2015) Jun Guan et al.   BMC Cardiovascular Disorders

Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats

(2015) Liliany S de Brito Amaral et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

(2015) C. Gimenes et al.   Journal of Diabetes Research

Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts

(2014) Ting-Wei Lee et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Low-Intensity Aerobic Exercise Mitigates Exercise-Induced Bronchoconstriction by Improving the Function of Adrenal Medullary Chromaffin Cells in Asthmatic Rats

(2014) Qingwu Qin et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Production of Reactive Oxygen Species in the Diabetic Heart

(2013) Yasushi Teshima et al.   CIRCULATION JOURNAL

Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation

(2013) Carlos Gonzalez-Quesada et al.   CIRCULATION RESEARCH

Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response

(2013) Li-Long Pan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Overexpression of Smad7 suppressed ROS/MMP9-dependent collagen synthesis through regulation of heme oxygenase-1

(2013) Hong Yu et al.   MOLECULAR BIOLOGY REPORTS

Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid

(2012) Chun-jun Li et al.   Cardiovascular Diabetology

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-olddb/dbmice by depleting cardiac glutathione

(2012) Ismail Laher et al.   FREE RADICAL RESEARCH

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes

(2009) S. Ares-Carrasco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide

(2009) Philip Newsholme et al.   CLINICAL SCIENCE

Effects of exercise intervention on myocardial function in type 2 diabetes

(2009) M D Hordern et al.   HEART

Endogenous angiotensin II has fewer effects but neuronal nitric oxide synthase has excitatory effects on renal sympathetic nerve activity in salt-sensitive hypertension-induced heart failure

(2009) Takehito Kemuriyama et al.   Journal of Physiological Sciences