Journal
JOURNAL OF PHYSIOLOGICAL SCIENCES
Volume 67, Issue 4, Pages 475-487Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s12576-016-0477-9
Keywords
Exercise preconditioning; Cardioprotection; C-type natriuretic peptide; Natriuretic peptide receptor B; Myocardial injury
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Funding
- National Natural Science Foundation of China [31071031, 31471136]
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To evaluate exercise preconditioning (EP)-induced cardioprotective effects against exercise-induced acute myocardial injury and investigate the alterations of C-type natriuretic peptide (CNP) and its specific receptor, natriuretic peptide receptor B (NPR-B), during EP-induced cardioprotection. Rats were subjected to treadmill exercise as an EP model (4 periods of 10 min each at 30 m/min with intervening periods of rest lasting 10 min). High-intensity exercise was performed 0.5 and 24 h after the EP. EP attenuated high-intensity exercise-induced myocardial injury in both the early and late phases. After EP and high-intensity exercise, CNP and NPR-B levels increased robustly, but no alterations in the plasma CNP were observed. The enhanced NPR-B, plasma and tissue CNP, and its mRNA levels after high-intensity exercise were significantly elevated by EP. These results suggest that cardiac CNP and NPR-B play an important role in EP-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats.
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