Article
Pharmacology & Pharmacy
Ahmad Alshehri, Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Tahani M. Almeleebia, Mohd Saeed, Dharmendra Kumar Yadav, Irfan Ahmad Ansari
Summary: The study revealed the antioxidant, anticancer, and anti-inflammatory activities of Adenium obesum, commonly known as desert rose, suggesting its potential as a herbal-based medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Bibiana Silva, Fabiola Carina Biluca, Luciano Valdemiro Gonzaga, Roseane Fett, Eduardo Monguilhott Dalmarco, Thiago Caon, Ana Carolina Oliveira Costa
Summary: This review emphasizes the anti-inflammatory properties of flavonoids found in honey, including their antioxidant effects and ability to inhibit pro-inflammatory enzymes and mediators. Studies demonstrate the modulatory effect of flavonoids on inflammatory cascades, but further clinical trials are needed to confirm the benefits of honeys from different botanical sources in diseases involving inflammation.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Fisheries
Roberta Imperatore, Graziella Orso, Serena Facchiano, Pierpaolo Scarano, Seyed Hossein Hoseinifar, Ghasem Ashouri, Carmine Guarino, Marina Paolucci
Summary: Supplementation of polyphenols from chestnut shells and mullein plants can ameliorate intestinal inflammation in zebrafish, reduce pro-inflammatory markers, increase anti-inflammatory cytokines and antioxidant activity. Polyphenols have a significant regulatory effect on intestinal inflammation in zebrafish.
Article
Neurosciences
Kaveh Rahimi, Mohammad Zalaghi, Elahe Ggazi Shehnizad, Ghazal Salari, Fatemeh Baghdezfoli, Akram Ebrahimifar
Summary: This research explores the potential benefits of alpha-pinene in alleviating nociception caused by the formalin test and the molecular mechanisms involved. Alpha-pinene was found to decrease nociceptive behaviors and regulate inflammatory and oxidative stress responses.
BRAIN RESEARCH BULLETIN
(2023)
Article
Chemistry, Organic
Qing Zhao, Long-Gao Xiao, Li-Sha Bi, Yu Si, Xiao-Mei Zhang, Jian-Hong Chen, Hai-Yang Liu
Summary: In this study, two novel labdane-type norditerpenoids were isolated from the rhizomes of Hedychium forrestii, and their structures were determined through spectroscopic analysis and X-ray single-crystal diffractions. One of the compounds showed a significant anti-inflammatory effect.
Article
Biochemistry & Molecular Biology
Jiyoon Yang, Won-Sil Choi, Ki-Joong Kim, Chang-Deuk Eom, Mi-Jin Park
Summary: This study demonstrated the anti-inflammatory activity of essential oil extracted from Korean pine wood and identified key anti-inflammatory constituents. These constituents showed potential for the management and treatment of inflammatory conditions, indicating possible development of novel anti-inflammatory drugs.
Article
Clinical Neurology
Huihui Liu, Mengxing Wang, Xianglong Xiang, Yuesong Pan, Jiejie Li, Xia Meng, Hao Li, Zixiao Li, Jing Jing, Yongjun Wang
Summary: This study found that persistent high residual inflammatory risk (RIR) increased the risks of stroke recurrence, composite vascular events, mortality, and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elvia Perez-Soto, Maria Olivia Medel-Flores, Eduardo Fernandez-Martinez, Rigoberto Oros-Pantoja, Jose Cruz Miranda-Covarrubias, Virginia Sanchez-Monroy
Summary: High-risk human papillomavirus (HR-HPV) infection, especially multiple infections, can lead to male infertility due to increased expression of CYP2E1, oxidative damage, and pro-inflammatory cytokine production.
Article
Veterinary Sciences
Amira Moustafa
Summary: Chronic circadian disruption results in changes in immune functions, clock genes expression, and antioxidant enzyme levels, leading to hematological disruptions and inflammatory responses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Dongjie Liu, Ningjing Zhou, Chiara Sanmartin, Xiaoguo Ying, Charles Brennan, Gengsheng Xiao, Lukai Ma, Linlin Li
Summary: Low-pressure plasma (LPP) treatment was found to have positive effects on preserving the flavor characteristics of lyophilized lemon slices. LPP treatment had minor effects on total sugars and total titrate acids, but prevented the storage losses of vitamin C (Vc) and phenols. LPP-treated lemon slices had a higher content of preferred aromatic substances with a citrus-like flavor.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rami S. Najjar, Shengyu Mu, Rafaela G. Feresin
Summary: Blueberry polyphenols demonstrate anti-hypertensive properties by reducing oxidative stress and increasing nitric oxide levels.
Article
Biochemistry & Molecular Biology
Yu Zhang, Zhao-Xi Deng, Mao-Long He, Jose J. Pastor, Gemma Tedo, Jian-Xin Liu, Hai-Feng Wang
Summary: Dietary supplementation with olive cake extract can alleviate oxidative stress and inflammation, improve intestinal morphology, and increase beneficial gut bacteria in piglets challenged with lipopolysaccharides.
Article
Agriculture, Dairy & Animal Science
Hongran Guo, Guangchen Zhou, Guangjie Tian, Yuyang Liu, Ning Dong, Linfang Li, Shijun Zhang, Haochen Chai, Yulin Chen, Yuxin Yang
Summary: The study found that in a cold environment, sheep had higher abundance of Lachnospiraceae in the rumen and lower levels of propionate, which may help the sheep survive in cold conditions without oxidative damage.
Review
Biochemistry & Molecular Biology
Natasha Ting Lee, Lin Kooi Ong, Prajwal Gyawali, Che Mohd Nasril Che Mohd Nassir, Muzaimi Mustapha, Harshal H. Nandurkar, Maithili Sashindranath
Summary: Cerebral endothelium plays a crucial role in regulating various physiological functions to maintain the health of the central nervous system. Cardiovascular risk factors contribute to cerebral endothelial dysfunction, leading to impaired vasodilation, aggravated inflammatory responses, increased oxidative stress, and vascular proliferation.
Article
Immunology
Maria Luisa Barcena, Sarah Jeuthe, Maximilian H. Niehues, Sofya Pozdniakova, Natalie Haritonow, Anja A. Kuehl, Daniel R. Messroghli, Vera Regitz-Zagrosek
Summary: The study revealed that male sex is associated with a higher incidence of cardiac fibrosis, stronger inflammation, and decreased cardiac function in autoimmune myocarditis, while females show an anti-inflammatory phenotype with better cardiac outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Maryam Alipour, Mohammad Reza Bigdeli, Hadi Aligholi, Bahram Rasoulian, Mojtaba Khaksarian
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2020)
Article
Biology
Maryam Owjfard, Mohammad Reza Bigdeli, Anahid Safari, Mohammad Reza Namavar
JOURNAL OF BIOSCIENCES
(2020)
Article
Neurosciences
Mahdieh Khoshnazar, Siavash Parvardeh, Mohammad Reza Bigdeli
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2020)
Article
Neurosciences
Maryam Owjfard, Mohammad Reza Bigdeli, Anahid Safari, Masoud Haghani, Mohammad Reza Namavar
Summary: The study found that DMF treatment for three days following cerebral ischemia did not significantly reduce neurological and motor function deficits or infarct volume. However, it did decrease neuronal area and death, while preserving their spatial distribution in a normal regular pattern.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Chemistry, Analytical
Fatemeh Mortazavi Moghadam, Mohammadreza Bigdeli, Ali Tamayol, Su Ryon Shin
Summary: A signal-on nanobiosensor based on aptamers was developed for measuring salivary cortisol levels. This novel sensor allows for measurement of cortisol in saliva without contamination by needle stress. The sensor's ultrasensitive detection method and ability to perform measurements in a single tube make it suitable for cases where salivary cortisol levels are lower compared to serum cortisol.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Neurosciences
Pariya Khodabakhsh, Maryam Bazrgar, Fatemeh Mohagheghi, Siavash Parvardeh, Abolhassan Ahmadiani
Summary: The role of miR-140-5p inhibition in promoting Pin1 expression and the therapeutic potential of AntimiR-140-5p in an A beta oligomer-induced Alzheimer's disease rat model were investigated. The results showed that miR-140-5p inhibitors markedly improved spatial learning and memory deficits induced by A beta O and suppressed the expression of inflammatory mediators and phosphorylation of tau protein. This study suggests that miR-140-5p inhibitors may be a promising agent for the treatment of Alzheimer's disease.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Kamran Rezaei, Mohammad-Abbas Sheikholeslami, Ebrahim Salimi-Sabour, Ensieh Lotfali, Siavash Parvardeh
Summary: The study found that Ganoderma lucidum extract significantly reduced symptoms in morphine-dependent mice, including jumps, leanings, and diarrhea. This suggests that G. lucidum extract has the potential to mitigate morphine dependence and inhibit withdrawal syndrome symptoms in mice.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2022)
Review
Cell Biology
Aida Karimian, Seyedeh Mahdieh Khoshnazar, Tahmineh Kazemi, Asadollah Asadi, Arash Abdolmaleki
Summary: After injury, peripheral nervous system neurons can rebuild their axons through a complicated activation response. Signals from the damaged axon and secreted signals from nearby Schwann cells play a critical role in this process. The secretome, which includes proteins, cytokines, growth factors, and extracellular vesicles, allows for multilayer communication and is essential for Wallerian degeneration and axonal regeneration. Mesenchymal stem cells (MSCs) are commonly used in neurological therapies because their secretome, including bioactive chemicals and extracellular vesicles, promotes peripheral nerve regeneration.
CELL AND TISSUE BANKING
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Shabani, Sohaila Erfani, Arash Abdolmaleki, Fatemeh Ephtekhar Afzali, Seyedeh Mahdieh Khoshnazar
Summary: a-Pinene protects the brain against ischemic damage by regulating iNOS -NF-kappa B- COX-2 and caspase-3 inflammatory and apoptotic pathways.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Medicine, Research & Experimental
Haider F. Al-Saedi, Hussein A. Ghanimi, Seyedeh Mahdieh Khoshnazar, Mohammad B. Ghayour, Arash Abdolmaleki
Summary: The study found that celastrol had significant neuroprotective effects in a rat sciatic nerve transection model, accelerating nerve regeneration and improving sensory and motor function recovery. The dose of 2 mg/kg outperformed the dose of 1 mg/kg in enhancing these effects.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Review
Nanoscience & Nanotechnology
Saman Roshancheshm, Asadollah Asadi, Seyedeh Mahdieh Khoshnazar, Arash Abdolmaleki, Zhikal Omar Khudhur, Shukur Wasman Smail
Summary: Extracellular vesicles (EVs), including exosomes, are small molecules produced by cells that can transfer functional biomolecules from one cell to another. Due to their similarities to the body's own cells and their nanoscale size, exosomes have become a promising strategy for targeted drug delivery.
NANOMEDICINE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Mohammad Bigdeli, Vahid Monfared
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
(2020)
Article
Cell Biology
Zeinab SafialHosseini, Mohammadreza Bigdeli, Sepideh Khaksar, Abbas Aliaghaei