Simvastatin Possesses Antitumor and Differentiation‐Promoting Properties That Affect Stromal Cells in Giant Cell Tumor of Bone

Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis

(2019) Mingmin Shi et al.   Cancer Management and Research

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Is vitamin D deficiency behind the scenes for high incidence of Giant cell tumor amongst the Indian population? Unraveling the vitamin D – RANKL association

(2018) Manit K. Gundavda et al.   MEDICAL HYPOTHESES

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

(2017) Javad Alizadeh et al.   Scientific Reports

Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue

(2017) Liangliang Xu et al.   Stem Cell Research & Therapy

Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota

(2015) Xiaohui Niu et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Novel Simvastatin-Loaded Nanoparticles Based on Cholic Acid-Core Star-Shaped PLGA for Breast Cancer Treatment

(2015) Yanping Wu et al.   Journal of Biomedical Nanotechnology

Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials

(2015)   LANCET

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A Translational Study of the Neoplastic Cells of Giant Cell Tumor of Bone Following Neoadjuvant Denosumab

(2014) Isabella W.Y. Mak et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Simvastatin Impairs Growth Hormone-Activated Signal Transducer and Activator of Transcription (STAT) Signaling Pathway in UMR-106 Osteosarcoma Cells

(2014) María Claudia Sandoval-Usme et al.   PLoS One

Pulmonary metastasis of giant cell tumor of bones

(2014) Aikeremujiang Muheremu et al.   World Journal of Surgical Oncology

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone

(2013) Carol P. Y. Lau et al.   CONNECTIVE TISSUE RESEARCH

Thyroid Hormones Decrease Plasma 1α,25-Dihydroxyvitamin D Levels Through Transcriptional Repression of the Renal 25-Hydroxyvitamin D31α-Hydroxylase Gene (CYP27B1)

(2013) Mina Kozai et al.   ENDOCRINOLOGY

Statins and Protein Prenylation in Cancer Cell Biology and Therapy

(2012) Carmen Garcia-Ruiz et al.   Anti-Cancer Agents in Medicinal Chemistry

Denosumab Induces Tumor Reduction and Bone Formation in Patients with Giant-Cell Tumor of Bone

(2012) D. G. Branstetter et al.   CLINICAL CANCER RESEARCH

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity

(2011) Timothy Miller et al.   DIGESTIVE AND LIVER DISEASE

Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species

(2011) Ho-Jin Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Giant Cell Tumor of Bone: Risk Factors for Recurrence

(2010) Frank M. Klenke et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone

(2010) Carol P.Y. Lau et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway

(2010) Pei-Yu Chen et al.   NUTRITION RESEARCH

Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling

(2010) Misuzu Yamashita et al.   REGULATORY PEPTIDES

Statins in tumor suppression

(2008) Antonella Sassano et al.   CANCER LETTERS

Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins

(2008) Griselda Herrero-Martin et al.   FEBS LETTERS

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway

(2008) Kwang Seok Ahn et al.   INTERNATIONAL JOURNAL OF CANCER