Article
Chemistry, Medicinal
You-Jia Hao, Zheng-Biao Zou, Ming-Min Xie, Yong Zhang, Lin Xu, Hao-Yu Yu, Hua-Bin Ma, Xian-Wen Yang
Summary: Two new xanthones (1 and 2) were isolated from deep-sea-derived fungus Penicillium sp. MCCC 3A00126, along with 34 known compounds (3-36). The structures of the new compounds were determined using spectroscopic data. The absolute configuration of compound 1 was confirmed by comparing experimental and calculated ECD spectra. Cytotoxicity and ferroptosis inhibitory activities of all isolated compounds were evaluated. Compounds 14 and 15 showed potent cytotoxicity against CCRF-CEM cells, with IC50 values of 5.5 and 3.5 μM, respectively. Compounds 26, 28, 33, and 34 exhibited significant inhibitory effects on RSL3-induced ferroptosis, with EC50 values of 11.6, 7.2, 11.8, and 2.2 μM, respectively.
Article
Chemistry, Medicinal
Cui-Ping Xing, Dan Chen, Chun-Lan Xie, Qingmei Liu, Tian-Hua Zhong, Zongze Shao, Guangming Liu, Lian-Zhong Luo, Xian-Wen Yang
Summary: Ten new and 26 known compounds were isolated from a deep sea-derived fungus Penicillium griseofulvum MCCC 3A00225. Compound 13 showed significant inhibition of degranulation release in vitro anti-food allergic bioactivities, with an IC50 value of 60.3 µM.
Article
Chemistry, Applied
Tian-Hua Zhong, Xian-Ming Zeng, Shi-Biao Feng, Hai-Tao Zhang, Yong-Hong Zhang, Zhu-Hua Luo, Wei Xu, Xin-Hua Ma
Summary: Three new phomalone derivatives and seven known analogues were isolated from a deep-sea-derived fungus, with phomalichenone F showing cytotoxic activity against human myeloma cancer cells U266 and compound 10 exhibiting cytotoxicity against multiple cancer cell lines.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Zheng-Biao Zou, Gang Zhang, Yu-Qi Zhou, Chun-Lan Xie, Ming-Min Xie, Lin Xu, You-Jia Hao, Lian-Zhong Luo, Xiao-Kun Zhang, Xian-Wen Yang, Jun-Song Wang
Summary: Six new citreoviridins and twenty-two known compounds were isolated from a deep-sea-derived fungus. The new compounds were determined by various spectroscopic methods, and the study also revealed the biological activities of some compounds.
Article
Biochemistry & Molecular Biology
Chun-Lan Xie, Qingmei Liu, Zhi-Hui He, Ying-Bao Gai, Zheng-Biao Zou, Zong-Ze Shao, Guang-Ming Liu, Hai-Feng Chen, Xian-Wen Yang
Summary: A total of 14 andrastones were isolated from the fungus Penicillium allii-sativi through UV-guided isolation. Among them, 3-deacetylcitreohybridonol showed promising anti-allergic bioactivity, indicating the potential for andrastones to be developed into new anti-allergic drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Meimei Cheng, Xuli Tang, Zongze Shao, Guoqiang Li, Qingqiang Yao
Summary: Four new aranotin-type epipolythiodioxopiperazines, along with four known analogues, were isolated from a deep-sea-derived fungus. Their structures and cytotoxic activities against cancer cells were studied.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Marina Simona Robescu, Giovanni Loprete, Matteo Gasparotto, Filippo Vascon, Francesco Filippini, Laura Cendron, Elisabetta Bergantino
Summary: This study aimed to expand the application scope of Old Yellow Enzymes (OYEs) and explore new enzymes from filamentous fungi. Four new members of the OYE superfamily were discovered from the genomes of Aspergillus niger and Botryotinia fuckeliana. The properties and crystal structures of these new enzymes revealed their unique features and conservation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Organic
Zhi-Hui He, Chun-Lan Xie, You-Jia Hao, Lin Xu, Chao-Feng Wang, Man-Yi Hu, Shu-Jin Li, Tian-Hua Zhong, Xian-Wen Yang
Summary: A unique C30 steroid, solitumergosterol A, was isolated from the deep-sea-derived fungus Penicillium solitum. Its planar structure and relative configuration were determined through extensive NMR and mass spectrometry analysis, while the absolute configuration was confirmed by comparing experimental and theoretical ECD spectra. This compound exhibited weak in vitro anti-tumor activity against MB231 cells through a RXR alpha-dependent mechanism.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Microbiology
Dongli Lv, Jinmei Xia, Xiaoqing Guan, Qiliang Lai, Beibei Zhang, Jianhui Lin, Zongze Shao, Sulan Luo, Dongting Zhangsun, Jiang-Jiang Qin, Weiyi Wang
Summary: Two new bioactive compounds were isolated from a deep-sea-derived fungus and their structures were determined. Compounds 1, 5-7 exhibited significant inhibition against Staphylococcus aureus, while compound 8 showed potent reduction in cell viability of gastric cancer cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Ya-Ping Liu, Sheng-Tao Fang, Zhen-Zhen Shi, Bin-Gui Wang, Xiao-Nian Li, Nai-Yun Ji
Summary: Five new compounds, including a natural phenylhydrazone-bearing steroid, were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep, showing unique structures and inhibition properties against marine phytoplankton species and marine-derived bacteria.
Article
Chemistry, Medicinal
Siwen Niu, Shuhuan Huang, Bihong Hong, Qixi Huang, Xiupian Liu, Zongze Shao, Gaiyun Zhang
Summary: Four novel monocyclic cyclopropane acids were isolated from the Aspergillus sydowii MCCC 3A00324 fungus, which were discovered in nature for the first time. These compounds exhibited antiviral activities against H1N1 influenza virus, with compound 1 showing a moderate inhibitory effect (IC50 = 26.7μM).
Article
Chemistry, Applied
Xuan Hong, Lingzhi Tang, Zhongwei Chen, Qiliang Lai, Beibei Zhang, Youwei Jiang, Xunjie Wang, Ruonan He, Jianhui Lin, Zongze Shao, Shan Lin, Weiyi Wang
Summary: Two new compounds, compounds 1 and 2, were isolated from the culture of a marine-derived fungus Talaromyces sp. MCCC 3A01752. Their structures were determined through detailed analysis, and one of the compounds showed antibacterial and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Li-Hong Yan, Feng-Yu Du, Xiao-Ming Li, Sui-Qun Yang, Bin-Gui Wang, Xin Li
Summary: Five new antibacterial indole diketopiperazine alkaloids were isolated and characterized from a fungal strain of Aspergillus chevalieri derived from a deep-sea cold seep. These compounds showed inhibitory activities against several pathogenic bacteria, with compound 6 potentially being a novel alternative for antibiotic development.
Article
Biochemistry & Molecular Biology
Xiaoyan Pang, Xuefeng Zhou, Xiuping Lin, Bin Yang, Xinpeng Tian, Junfeng Wang, Shihai Xu, Yonghong Liu
Summary: Several new sorbicillinoid compounds were isolated from a deep-sea sediment-derived fungus, exhibiting inhibitory activities against enzymes and bacteria. Some of these compounds displayed stronger inhibitory effects compared to standard drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yanhe Li, Xiaoming Li, Xin Li, Suiqun Yang, Bingui Wang, Honglei Li
Summary: Six novel verrucosidin derivatives were isolated and identified from a deep-sea-derived fungus collected in the South China Sea. These compounds exhibited inhibitory activities against several human and aquatic pathogens, highlighting the scientific significance of studying deep-sea-derived fungi.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Zhi-Hui He, Chun-Lan Xie, Taizong Wu, Yu-Ting Yue, Chao-Feng Wang, Lin Xu, Ming-Min Xie, Yong Zhang, You-Jia Hao, Ren Xu, Xian-Wen Yang
Summary: Chemical investigation of the deep-sea-derived fungus Rhizopus sp. W23 led to the discovery of six new and 12 known cyclocitrinol analogues, as well as one handling artifact, all with unique structures. Compound 13 demonstrated significant potential as an antiosteoporosis lead through its ability to enhance osteoblastogenesis and inhibit adipogenesis in mature bone marrow stromal cells at 5 μM.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Physical
Wei Zhang, Yuanyuan Gou, Li Cheng, Kaiwei Dong, Yijie Sheng, Chao Ye, Xianqing Yang, Yuguang Mu
Summary: This study investigates the disruption of phosphorene oxide (PO) to a protein structure and finds that the disruption is enhanced with increasing oxidation concentration of PO. The oxidation mode of PO has limited effect on the interaction between PO and the protein. PO with low oxidation concentration is biocompatible with the protein. Oxygen atoms filling into the surface of phosphorene enhance its interaction with the protein and increase the disruption. The electrostatic interaction between PO and the protein has negligible effect on the structural damage. These findings have implications for the biological toxicity and potential biomedical applications of PO nanosheets.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Textiles
Xuan Yang, Yunbo Zheng, Xiaohui Liu, Yuanlin Ren, Xianwen Yang, Qiuyan Zhang
Summary: Creatinine O-phosphate (COP) was used as an eco-friendly flame retardant for lyocell/cotton blended fabric, providing high flame retardancy, excellent washing resistance and thermal stability.
JOURNAL OF NATURAL FIBERS
(2023)
Editorial Material
Microbiology
Junfeng Wang, Xianwen Yang, Li Liao, Martina Cappelletti, Mirko Basen
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oceanography
Changyou Wang, Ping Zheng, Rongguo Su, Zhuhua Luo, Yuanzhi Zhang, Longjiang Mao
Summary: Several studies have found that green macroalgae blooms, known as 'green tide' events, do not significantly affect the levels of dissolved inorganic phosphorus (DIP) in aquatic ecosystems. This study analyzed surface sediment samples and water samples to study phosphorus cycling and replenishment in Subei shoal. The results showed that total phosphorus (TP) in the sediment and dissolved inorganic phosphorus in the water varied, and the behavior of DIP was influenced by suspended particulate matter (SPM).
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2023)
Article
Microbiology
Wenzhen Lin, Xin Liu, Linfeng Gong, Ruzhen Liu, Minghuang Ling, Chiming Guo, Hongyan Meng, Zhuhua Luo, Xiaona Du, Ying Guo, Wei Xu
Summary: This study aims to investigate the relationship between environmental factors and fungal diversity in the Shenzhen River ecosystem. The results showed that the sediments in the river are rich in fungal diversity, and fungal abundance is correlated with NH4+ while Shannon index is correlated with pH and IC. Furthermore, the majority of fungi in the area are saprotrophs, highlighting their potential role in organic matter decomposition and nutrient cycling.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Limnology
Wei Xu, Change Yang, Yu Luo, Kai Zhang, Mingliang Chen, Shuangcheng Jiang, Hans-Peter Grossart, Zhuhua Luo
Summary: Increasing evidence suggests that fungal communities are key components of biogeochemical cycles in coastal ecosystems, but the major drivers of fungal diversity in areas impacted by mariculture are largely unknown. A study in Dongshan Bay, China, revealed a highly diverse fungal community with the dominance of Dikarya species and occasional predominance of other taxa. Fungal diversity varied more with season than with the degree of aquaculture activity, and environmental factors like temperature, dissolved oxygen, and nitrite had the greatest impact on community structure.
LIMNOLOGY AND OCEANOGRAPHY
(2023)
Review
Nutrition & Dietetics
Tianxiang Wu, Zhenxing Li, Yanyan Wu, Xianqing Yang, Laihao Li, Shengjun Chen, Bo Qi, Yueqi Wang, Chunsheng Li, Yongqiang Zhao
Summary: The active substances derived from plants have gained increasing attention due to their wide range of pharmacological applications, including anti-tumor, anti-allergic, anti-viral, and anti-oxidative activities. Polyphenols from plants have significant anti-allergic effects and serve as an important source for anti-allergic drug research and development. This article reviews the recent advances in the anti-allergic efficacy of plant polyphenols, discussing their comprehensive effects on cellular or animal models. In addition, the current issues and future directions for the development and utilization of these active substances as anti-allergic products are also discussed.
FRONTIERS IN NUTRITION
(2023)
Article
Food Science & Technology
Mingchang Yang, Lizhen Ma, Xianqing Yang, Laihao Li, Shengjun Chen, Bo Qi, Yueqi Wang, Chunsheng Li, Ya Wei, Di Wang, Yongqiang Zhao
Summary: Porphyra dentata is a cultivated algae with varying quality. The molecular mechanism of quality differences is not well understood. Photosynthesis plays a key role in plant development and quality changes. Comparing transcriptomic and proteogenomic data of different harvests, we identified differentially expressed genes and proteins related to quality differences. Our results provide insights into the quality improvement and evolutionary function analysis of P. dentata.
Article
Biochemistry & Molecular Biology
Zhi-Hui He, Chun-Lan Xie, Taizong Wu, Yong Zhang, Zheng-Biao Zou, Ming-Min Xie, Lin Xu, Robert J. Capon, Ren Xu, Xian-Wen Yang
Summary: Marine fungi are a valuable source of diverse and bioactive compounds. In this study, a fungus from deep-sea was found to produce a class of citrinins, including three new citrinin trimers, with a unique carbon scaffold. The absolute configurations of these compounds were determined using spectroscopic analysis, theoretical-statistical approaches, and biogenetic consideration. One of the compounds, neotricitrinol B, showed potential anti-osteoporosis activity on primary bone mesenchymal stem cells.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hao-Yu Yu, Yan Li, Meng Zhang, Zheng-Biao Zou, You-Jia Hao, Ming-Min Xie, Li-Sheng Li, Da-Li Meng, Xian-Wen Yang
Summary: A new alkaloid was isolated from a deep-sea-derived Penicillium citrinum, along with 25 known compounds. The isolated alkaloid showed inhibitory effects on ferroptosis and cuproptosis, similar to other compounds with similar structures.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biotechnology & Applied Microbiology
Yu Luo, Wei Xu, Xiaotian Zuo, Minghuang Ling, Ruzhen Liu, Kai Zhang, Zhichao Wang, Yuanhao Gao, Hans-Peter Grossart, Zhuhua Luo
Summary: The study obtained a natural aerobic denitrifying consortium, named C3, from a coastal mariculture area in Fujian Province, China. It showed good and stable nitrate removing performance, and high-throughput sequencing revealed that Pseudomonas and Fusarium were dominant bacterial and fungal species in the consortium. Four Pseudomonas strains were successfully isolated, supporting the inference that Pseudomonas was the main contributor. These findings provide novel insights into the biotechnological nitrogen pollution removal in mariculture environments.
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2023)
Article
Virology
Zhiqing Wang, Andrei Fokine, Xinwu Guo, Wen Jiang, Michael G. Rossmann, Richard J. Kuhn, Zhu-Hua Luo, Thomas Klose
Summary: Antibiotic resistance is a growing threat to public health, and new tools are needed to combat pathogenic bacteria. Contractile injection systems, such as bacteriophage tails, pyocins, and bacterial type VI secretion systems, have the potential to efficiently penetrate cell envelopes and act as antibacterial agents.
Article
Mechanics
Wei Zhang, Yunqiu Yang, Na Li, Yimin Liu, Tianxu Kou, Danni Cui, Yaxuan Shen, Xianqing Yang, Wei Chen
Summary: Using optical microscopy and multiparticle tracking techniques, the correlated diffusion of colloidal particles over a rugged surface was investigated. The hydrodynamic interactions of the particles confined to energy landscapes displayed a distinct power-law behavior. The local energy landscape on the rugged surface reduced the long-range hydrodynamic interactions between colloidal particles. The findings provide physical insights into confinement hydrodynamics and have implications for designing material surfaces and controlling particle motion on rough surfaces.
Article
Chemistry, Medicinal
Zheng-Biao Zou, Tai-Zong Wu, Long-He Yang, Xi-Wen He, Wen-Ya Liu, Kai Zhang, Chun-Lan Xie, Ming-Min Xie, Yong Zhang, Xian-Wen Yang, Jun-Song Wang
Summary: Through a systematic investigation, new compounds were isolated from the metabolites of the deep-sea-derived fungus, and their anti-inflammatory activity was tested. Compound 22 exhibited the most remarkable inhibitory activity.