Article
Cell Biology
Meilin Hu, Liangyu Xing, Li Zhang, Fan Liu, Sheng Wang, Ying Xie, Jingjing Wang, Hongmei Jiang, Jing Guo, Xin Li, Jingya Wang, Lei Sui, Changyi Li, Dayong Liu, Zhiqiang Liu
Summary: The elevation of NAP1L2 expression is correlated with the senescence and impaired osteogenesis of BMSCs, and NAP1L2 regulates BMSC cell senescence and osteogenic differentiation through NF-kappa B pathway, H3K14ac modification, and chromatin accessibility. Additionally, there is a potential interaction between NAP1L2 and the anti-aging reagent NMN, which alleviates senescent phenotypes of BMSCs. These findings provide a new theoretical basis for aging-related diseases.
Article
Biotechnology & Applied Microbiology
Yihui Chai, Xiang Pu, Yongzhen Wu, Xingzhong Tian, Qian Li, Fanyong Zeng, Jing Wang, Jie Gao, Huaqian Gong, Yunzhi Chen
Summary: The study demonstrated that Astragalus Membranaceus can improve bone density and microstructure, promote osteogenesis, and alleviate osteoporosis in a dose-independent manner in SAMP6 mice. This provides new insight for the treatment of spontaneous senile osteoporosis and serves as a research basis for the application of Astragalus Membranaceus.
Article
Cell Biology
Ze Long, Pengcheng Dou, Weiliang Cai, Minzhi Mao, Ren Wu
Summary: High-throughput miRNA sequencing of osteoporosis from the GEO database identified miR-181a-5p as a differentially expressed microRNA. Modulation of miR-181a-5p levels in MC3T3-E1 cells affected osteogenic differentiation. Target gene prediction revealed BMP3 as a target of miR-181a-5p. Reduced expression of miR-181a-5p was validated in osteoporotic patients, implicating its importance in disease prevention.
Article
Cell & Tissue Engineering
Jingjing Shao, Shibo Liu, Min Zhang, Shujiang Chen, Shuaiqi Gan, Chenfeng Chen, Wenchuan Chen, Lei Li, Zhimin Zhu
Summary: This study aimed to investigate the role of HIF1 alpha in aged bone and its regulation of osteogenesis and angiogenesis. The results showed that HIF1 alpha exhibited different effects in aged bone and may be associated with the ROS-mediated HIF1 alpha-p53 relationship.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nutrition & Dietetics
Wei Su, Chen Lv, Lingtuo Huang, XiaoHang Zheng, Shengwu Yang
Summary: This study suggests that glucosamine (GlcN) can effectively delay the progression of senile osteoporosis by promoting osteoblast autophagy, and may be a potential candidate drug for the treatment of this disease.
NUTRITION & METABOLISM
(2022)
Article
Food Science & Technology
Eun-Ji Song, Min Jung Kim, Chang Hwa Jung, Won-Hyong Chung, Young-Do Nam, Mi Young Lim
Summary: This study aimed to investigate the effect of the traditional fermented soybean food Cheonggukjang on gut microbial composition and isoflavone metabolites in healthy Korean individuals. The results showed that the gut microbial composition was associated with the changes in the gut microbiota and isoflavone-metabolite profiles after CKJ supplementation. This highlights the importance of personalized nutrition guidance based on an individual's gut microbial composition.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cell Biology
Houlin Ji, Xu Cui, Yang Yang, Xiaoxiao Zhou
Summary: The study revealed the important role of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells and the pathogenesis of senile osteoporosis. It suggested that hsa_circ_0006215 could be a novel target for treating senile osteoporosis.
Review
Endocrinology & Metabolism
Weidong Zhang, Ruihan Gao, Xing Rong, Siqi Zhu, Yajun Cui, Hongrui Liu, Minqi Li
Summary: This article summarizes the response of the immune system in different types of osteoporosis, highlighting the important role of immune cells in bone loss.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Xiaoli Hou, Faming Tian
Summary: This review explores the role and molecular mechanism of the STAT3 signaling pathway in osteoporosis, particularly its regulation by bone-related cytokines. It also examines the cellular interactions among immune cells, hematopoietic cells, and osteoblastic/osteoclastic cells.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell & Tissue Engineering
So-Young Lee, Hyun-Ju An, Jin Man Kim, Min-Ji Sung, Do Kyung Kim, Hyung Kyung Kim, Jongbeom Oh, Hye Yun Jeong, Yu Ho Lee, Taeyoung Yang, Jun Han Kim, Ha Jeong Lim, Soonchul Lee
Summary: PINK1 is critical for mitochondrial quality control and decreasing reactive oxygen species production during osteoblast differentiation. Inhibition of PINK1 leads to impaired osteoblast differentiation and defects in mitochondrial homeostasis, while activation of PINK1 may be a potential treatment target for bone diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Shi Yin, Sihan Lin, Jingyi Xu, Guangzheng Yang, Hongyan Chen, Xinquan Jiang
Summary: As societal aging intensifies, senile osteoporosis has become a global public health concern. This study reveals that extracellular vesicles derived from senescent bone marrow mesenchymal stem cells enhance osteoclast differentiation leading to osteoporosis and implant failure. An exosome-targeted orthopedic implant with a nutrient coating is developed to address this issue, which can inhibit bone resorption, induce senile osteogenesis, and modulate osteoclast dialogue. The study also identifies a key regulator, miR-146b-5p, which regulates the protein kinase B/mammalian target of rapamycin pathway, and demonstrates the effectiveness of the nutrient coating in promoting bone remodeling and osseointegration in an osteoporotic rat model.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Huaqiang Tao, Yunxia Tao, Chen Yang, Wenming Li, Wei Zhang, Xueyan Li, Ye Gu, Yujing Hong, Huilin Yang, Yu Liu, Xing Yang, Dechun Geng
Summary: Urolithin A (Uro-A) has been shown to have protective effects in senile osteoporosis, by inhibiting osteoclastogenesis, enhancing autophagy ability, and blocking the MARK signaling pathway, leading to prevention of bone loss in aging mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiangna Wang, Shiwei Liu, Yuxiang Zhao, Syed Shah Zaman Haider Naqvi, Ruixue Duan
Summary: This meta-analysis explores the relationship between adipokines levels (leptin, adiponectin, and chemerin) and the incidence of senile osteoporosis. The findings indicate that older individuals with lower levels of leptin and higher levels of chemerin are more likely to have senile osteoporosis. Additionally, there is a significant positive correlation between levels of leptin and adiponectin and body mass index.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
QianKun Yang, YuChi Zou, XiaoYu Wei, Peng Ye, YuTong Wu, HongBo Ai, Zhao Zhang, JiuLin Tan, Jiangling Zhou, YuSheng Yang, QiJie Dai, Ce Dou, Fei Luo
Summary: This study demonstrated that senescence of bone marrow mesenchymal stem cells (BMSCs) is the basis of senile osteoporosis (SOP), and protein tyrosine phosphatase 1B (PTP1B) plays a crucial role in BMSCs senescence and SOP. PTP1B silencing effectively alleviates senescence, improves mitochondrial dysfunction, and restores osteogenic differentiation in aged BMSCs through enhanced mitophagy mediated by the PKM2/AMPK pathway. Targeting PTP1B may represent a promising interventional strategy to attenuate SOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Agriculture, Multidisciplinary
Cheng-Liang Xie, Ki H. Park, Sang S. Kang, Kye M. Cho, Dong H. Lee
Summary: The study indicates that isoflavone-enriched soybean leaves (IESLs) can attenuate postmenopausal osteoporosis by suppressing inflammation and osteoclastogenesis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Cell Biology
Da-Hye Lee, So-Hyun Park, Jiyun Ahn, Seung Pyo Hong, Eunyoung Lee, Young-Jin Jang, Tae-Youl Ha, Yang Hoon Huh, Seung-Yeon Ha, Tae-Il Jeon, Chang Hwa Jung
Summary: The study revealed that inhibition of Mir214-3p expression alleviated fatty liver disease by increasing autophagic activity through upregulation of Ulk1. Mir214-3p is a potential therapeutic target for nonalcoholic fatty liver disease.
Article
Cell Biology
Hyunjung Lee, Young In Kim, Farida S. Nirmala, Ji-Sun Kim, Hyo-Deok Seo, Tae Youl Ha, Young-Jin Jang, Chang Hwa Jung, Jiyun Ahn
Summary: Post-menopausal conditions exacerbate the biological aging process, leading to visceral adiposity and sarcopenia. Mitochondrial impairment, along with the upregulation of miR-141-3p and subsequent downregulation of Fkbp5 and Fibin, plays a role in the development of obesogenic sarcopenia. Inhibiting miR-141-3p could be a potential therapeutic target for alleviating this condition.
Article
Chemistry, Applied
Jisong Ahn, Min Jung Kim, Ahyoung Yoo, Jiyun Ahn, Tae Youl Ha, Chang Hwa Jung, Hyo Deok Seo, Young Jin Jang
Summary: Codium fragile (CF) is a type of green algae consumed as kimchi in Asia, containing beneficial compounds for skeletal muscle health. Extracts from CF enhance protein synthesis, myogenic differentiation, oxidative muscle fiber formation, and mitochondrial biogenesis through specific signaling pathways, making it a potential food source for sport nutrition or sarcopenia prevention. Canthaxanthin, a new compound in CF extracts, contributes synergistically to the effects of CF.
Article
Plant Sciences
Da-Hye Lee, So-Hyun Park, Eunyoung Lee, Hyo-Deok Seo, Jiyun Ahn, Young-Jin Jang, Tae-Youl Ha, Seung Soon Im, Chang Hwa Jung
Summary: This study demonstrates that WFA reduces obesity by increasing energy expenditure, improving mitochondrial activity, and promoting white adipose tissue browning. The mechanism involves activation of AMPK and MAPK signaling pathways.
Article
Food Science & Technology
Jisong Ahn, Hyo Jeong Son, Hyo Deok Seo, Tae Youl Ha, Jiyun Ahn, Hyunjung Lee, Seung Ho Shin, Chang Hwa Jung, Young Jin Jang
Summary: The study demonstrated that gamma-Oryzanol enhances skeletal muscle function in aged mice by regulating PPAR delta and ERR gamma activity, improving oxidative capacity and attenuating muscle weakness without significant muscle gain.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Jaesang Kim, Wanho Kim, Jisong Ahn, Young Jin Jang, Hyung-Soon Park, Jessie S. Jeon
Summary: The study investigates the combined effects of cyclic stretch and hypoxia on the recovery of oxidative damaged skeletal muscle cells. The results show that cyclic stretch and hypoxia facilitate muscle recovery, with HIF-1 alpha and antioxidants playing a key role in the process.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Food Science & Technology
Jae-Hoon Lee, Yun-Yeol Lee, Jangho Lee, Young-Jin Jang, Hae-Won Jang
Summary: The study investigated the chemical composition and antioxidant anti-inflammatory activity of essential oil from Schisandra chinensis fruits, confirming its significant inhibitory effects on ROS and NO production. OMEO, containing compounds like α-pinene and nerolidol, showed excellent potential as a functional food ingredient with antioxidant and anti-inflammatory properties.
Article
Plant Sciences
Ahyoung Yoo, Young Jin Jang, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha
Summary: DMBQ was shown to increase skeletal muscle mass and performance by regulating the AKT/mTOR signaling pathway and enhancing mitochondrial function, which might be beneficial for the treatment and prevention of skeletal muscle atrophy.
Article
Biochemical Research Methods
Jisong Ahn, Jaesang Kim, Jessie S. Jeon, Young Jin Jang
Summary: Exercise plays a critical role in maintaining and improving skeletal muscle. This study developed a motion-mimicking system using a three-dimensional cellular model to analyze the changes induced by resistance exercise at both morphological and molecular levels.
Review
Biotechnology & Applied Microbiology
Young Jin Jang
Summary: Sarcopenia is a condition of age-related muscle mass, strength, and performance decline, associated with chronic diseases and increased mortality. Adequate intake of protein and vitamin D is important in counteracting sarcopenia. Additionally, amino acids, leucine, beta hydroxy beta-methylbutyrate (HMB), creatine, and citrulline are suggested as supplements for muscle health and to control sarcopenia.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Sun Kim, Ha Lim Lee, Ji Hyun Jeong, Ye Eun Yoon, In-Ryeong Lee, Ji Min Kim, Chunyan Wu, Sung-Joon Lee
Summary: The expression of olfactory receptor OR2AT4 in human skin cells promotes wound healing and hair growth, while also playing a crucial role in regulating the aging and senescence of human keratinocytes.
Article
Food Science & Technology
Justin Jaesuk Lee, Byeong Min Ahn, Nara Kim, Yuran Noh, Hee Ju Ahn, Eun Sol Hwang, Jaewon Shim, Ki Won Lee, Young Jin Jang
Summary: Skeletal muscle loss has negative impacts on quality of life, chronic disease incidence, and mortality. To find functional food materials that can alleviate muscle atrophy, a multitarget-based machine learning system was built to identify novel phytochemicals. The system successfully identified citrusinol, which showed anti-atrophy effects through various pathways, including protein synthesis and myogenic differentiation. Citrusinol also attenuated myotube atrophy induced by CT26 by blocking specific factors. This study demonstrates the effectiveness of the proposed model in identifying functional foods and highlights citrusinol as a potential candidate for further animal experiments.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Young Jin Jang, Sanguine Byun
Summary: The article suggests that people who are unable to participate in physical exercise can consider using pharmacological interventions to mimic the positive effects of exercise. Recent studies have found that exercise mimetics can partially simulate the health benefits of exercise, and discuss the potential advantages of using natural products as a multitargeting agent to mimic the health-promoting effects of exercise.
Article
Gastroenterology & Hepatology
Chunyan Wu, Mi-Young Jeong, Jung Yeon Kim, Giljae Lee, Ji-Sun Kim, Yu Eun Cheong, Hyena Kang, Chung Hwan Cho, Jimin Kim, Min Kyung Park, You Kyoung Shin, Kyoung Heon Kim, Geun Hee Seol, Seung Hoi Koo, GwangPyo Ko, Sung-Joon Lee
Summary: Studies have shown that AzA activates Olfr544 in the gut, leading to anti-obesity effects through regulating GLP-1 secretion, gut microbiome, metabolites, and colonic inflammation.