Article
Biotechnology & Applied Microbiology
Chuan Zhang, Huiping Zhu, Hui Jie, Hengyue Ding, Hongwen Sun
Summary: Arbutin has protective effects in ulcerative colitis, potentially through the regulation of inflammatory factors and the maintenance of intestinal barrier function. Its mechanism of action may be associated with the MAPK/ELK1 pathway.
Article
Pharmacology & Pharmacy
Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li
Summary: Coptisine has demonstrated therapeutic effects on ulcerative colitis by maintaining the integrity of the intestinal epithelial barrier, inhibiting apoptosis, and inflammatory response.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ui-Jin Bae, Ha-Na Jang, Sung-Hyen Lee, Ji-Young Kim, Gi-Chang Kim
Summary: The study investigated the anti-inflammatory and antioxidant effects of Oenanthe javanica ethanol extract (OJE) in mice with DSS-induced colitis. Results showed that OJE treatment reduced inflammation, protected the colon, and modulated gut microbial composition, suggesting potential benefits for colitis treatment.
Article
Chemistry, Multidisciplinary
Yong-Deok Jeon, Ji-Hyun Lee, Sa-Haeng Kang, Hyun Myung, Jong-Sik Jin
Summary: The study found that Lingonberry extract has potential therapeutic effects for patients with ulcerative colitis, as it can reduce weight loss, lengthen the colon, and improve the secretion of inflammatory cytokines.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Saleh A. Almatroodi, Ahmad Almatroudi, Amjad Ali Khan, Arshad Husain Rahmani
Summary: Cancer is a leading cause of death worldwide, and natural compounds like formononetin have been shown to inhibit cancer growth through their antioxidant and anti-inflammatory effects. Formononetin, a type of isoflavone, regulates inflammation, angiogenesis, cell cycle, and apoptosis, and has been proven effective against various cancer types. This review emphasizes the role of formononetin in different cancers and its influence on cell signaling pathways. Further clinical trials are needed to explore its potential in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ahmad Almatroudi, Khaled S. S. Allemailem, Wanian M. M. Alwanian, Basmah F. F. Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A. A. Almatroodi, Arshad Husain Rahmani
Summary: Cancer is a leading cause of death worldwide and its incidence is increasing. Natural compounds, such as kaempferol found in vegetables and fruits, have shown potential in cancer management with minimal side effects. Kaempferol has been proven to modulate cell signaling pathways and induce apoptosis and cell cycle arrest in cancer cells. However, more clinical trials are needed to fully explore its therapeutic role, especially in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Jae Dong Son, Su-Jin Hwang, Jong Kwang Lee, Jae Young Park, Kwang Il Park, Tae Woo Oh
Summary: Fermented glutinous rice can improve ulcerative colitis by regulating the expression of tight junction proteins, reducing inflammation, and inhibiting apoptosis. The treatment with fermented glutinous rice can protect the intestinal barrier function, suppress inflammation, and prevent apoptosis, making it a potential candidate for treating and preventing inflammatory bowel disease.
Article
Food Science & Technology
Qingfan Qian, Dong Qiu, Zhengli Wu, Hao Yang, Yisha Xie, Shilan Li, Yan Yin, Xinli Li
Summary: The effects of apple polyphenol extract (APE) on DSS-induced UC and behavioral disorders were explored. APE treatment improved symptoms of UC and behavioral disorders by regulating signaling pathways and intestinal microbiota. These findings suggest that APE has potential as a treatment for UC.
Article
Biochemistry & Molecular Biology
Yao-Yao Li, Yu Cui, Wan-Rong Dong, Tian-Tian Liu, Gao Zhou, Yu-Xin Chen
Summary: This study investigated the therapeutic effect of ethyl acetate extract (TBEA) from Terminalia bellirica fruit on ulcerative colitis (UC). The results showed that TBEA significantly alleviated UC symptoms by reducing oxidative stress, inflammation, as well as regulating intestinal flora structure. These findings provide new insights for the development of TBEA as a potential treatment for UC.
Review
Biochemistry & Molecular Biology
Arshad Husain Rahmani, Ahmad Almatroudi, Khaled S. S. Allemailem, Wanian M. M. Alwanian, Basmah F. F. Alharbi, Faris Alrumaihi, Amjad Ali Khan, Saleh A. A. Almatroodi
Summary: Cancer is a global health concern, and current cancer treatments often cause adverse complications. Myricetin, a natural antioxidant found in medicinal plants, has shown potential in cancer prevention and management through its anti-inflammatory and hepato-protective properties. It also has the ability to modulate cell signaling molecules and enhance the effectiveness of other anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Arshad Husain Rahmani, Ali Yousif Babiker, Shehwaz Anwar
Summary: Cancer is a major cause of death worldwide, and current therapies have side effects. Natural products, containing bioactive ingredients, can modulate oxidative stress, inflammation, and cell signaling to manage diseases. Hesperidin, commonly found in citrus fruits, has antioxidant, anti-inflammatory, hepatoprotective, and cardio-preventive properties. It shows anticancer potential by modulating various cell signaling pathways, such as apoptosis, cell cycle, angiogenesis, and ERK/MAPK. It can also synergistically enhance the effects of anticancer drugs and other natural compounds.
Article
Plant Sciences
Jiajia Zhao, Rui Wu, Panhong Wei, Ziyan Ma, Heying Pei, Jingwen Hu, Feiyan Wen, Li Wan
Summary: The therapeutic effect and molecular mechanisms of Piper wallichii extract on DSS-induced ulcerative colitis in mice were investigated. The extract improved the symptoms of ulcerative colitis mice by enhancing intestinal barrier function, regulating inflammatory factors, and modulating the immune system. The TLR4/NF-Kappa B/COX-2 signaling pathway was found to be involved in the anti-inflammatory effect of Piper wallichii extract.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Haojie Zhang, Yujin Wang, Fengyuan Gao, Rucheng Liu, Wen Chen, Xue Zhao, Qian Sun, Xiaotong Sun, Jingxin Li, Chuanyong Liu, Xuelian Ma
Summary: Gamma-aminobutyric acid (GABA) is a bioactive molecule with potential health benefits, but its involvement in intestinal inflammation is debated. This study found that GABA treatment increases susceptibility to colitis in mice and induces an intestinal barrier defect by inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Jiapei Cai, Jiuxi Liu, Peng Fan, Xue Dong, Kunpeng Zhu, Xiaobo Liu, Naisheng Zhang, Yongguo Cao
Summary: Dioscin, a natural steroid saponin derived from plants of the genus Dioscoreaceae, shows protective effects on DSS-induced colitis in mice by reducing disease activity, maintaining intestinal barrier function, and inhibiting excessive inflammation. It may be a promising candidate for future ulcerative colitis therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shiyu Li, Tianmin Wang, Binning Wu, Wenyi Fu, Baojun Xu, Ramachandra Reddy Pamuru, Mary Kennett, Jairam K. P. Vanamala, Lavanya Reddivari
Summary: Purple-fleshed potato has significant anti-inflammatory potential in suppressing inflammatory responses in a colitis mouse model, alleviating symptoms such as weight loss and colon shortening, and reducing the abundance of pathogenic bacteria and immune mediators.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)