Characterization of the Ontogeny of Hepatic UDP‐Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes

Empirical models for anatomical and physiological changes in a human mother and fetus during pregnancy and gestation

(2019) Dustin F. Kapraun et al.   PLoS One

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol-N-glucuronide by African American Smokers

(2018) Sharon E. Murphy et al.   CHEMICAL RESEARCH IN TOXICOLOGY

State-of-the-Art Review on Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development

(2018) Venkata Yellepeddi et al.   CLINICAL PHARMACOKINETICS

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

(2018) Justine Badée et al.   CLINICAL PHARMACOKINETICS

Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver

(2018) Deepak Kumar Bhatt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex

(2018) Deepak Kumar Bhatt et al.   DRUG METABOLISM AND DISPOSITION

Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes

(2018) Ang Chen et al.   TOXICOLOGY LETTERS

Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

(2018) Justine Badée et al.   DRUG METABOLISM AND DISPOSITION

Physiologically Based Pharmacokinetic Modeling in Regulatory Science: An Update From the U.S. Food and Drug Administration’s Office of Clinical Pharmacology

(2018) Manuela Grimstein et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk

(2016) Dong Gui Hu et al.   DRUG METABOLISM REVIEWS

Hepatic expression of transcription factors affecting developmental regulation of UGT1A1 in the Han Chinese population

(2016) Ya-li Nie et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children

(2016) Elizabeth Neumann et al.   Frontiers in Pharmacology

Strong Specific Inhibition of UDP-glucuronosyltransferase 2B7 by Atractylenolide I and III

(2015) Qian Zhang et al.   PHYTOTHERAPY RESEARCH

Human Hepatic UGT2B15 Developmental Expression

(2014) Karthika Divakaran et al.   TOXICOLOGICAL SCIENCES

The UDP-glucuronosyltransferases: Their role in drug metabolism and detoxification

(2013) Andrew Rowland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Association of UGT1A1*28 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians

(2013) X Liu et al.   PHARMACOGENOMICS JOURNAL

Inhibition of Morphine Glucuronidation in the Liver Microsomes of Rats and Humans by Monoterpenoid Alcohols

(2012) Yuji Ishii et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of Residues That Confer Sugar Selectivity to UDP-Glycosyltransferase 3A (UGT3A) Enzymes

(2012) Robyn Meech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

(2011) S. J. Miyagi et al.   DRUG METABOLISM AND DISPOSITION

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA