Functional diversification of IgGs through Fc glycosylation

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

(2019) Marion Espéli et al.   Nature Communications

Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease

(2018) Jose D. Pagan et al.   CELL

Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation

(2017) Christin Brückner et al.   INTERNATIONAL IMMUNOLOGY

Identification of sequence variants influencing immunoglobulin levels

(2017) Stefan Jonsson et al.   NATURE GENETICS

Differential antibody glycosylation in autoimmunity: sweet biomarker or modulator of disease activity?

(2017) Michaela Seeling et al.   Nature Reviews Rheumatology

Obinutuzumab for the First-Line Treatment of Follicular Lymphoma

(2017) Robert Marcus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increasing the breadth and potency of response to the seasonal influenza virus vaccine by immune complex immunization

(2017) Jad Maamary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulating IgG effector function by Fc glycan engineering

(2017) Tiezheng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgG antibodies to dengue enhanced for FcγRIIIA binding determine disease severity

(2017) Taia T. Wang et al.   SCIENCE

Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia

(2016) Myrthe E. Sonneveld et al.   BRITISH JOURNAL OF HAEMATOLOGY

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

(2016) Stylianos Bournazos et al.   CELL

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

(2016) René Pfeifle et al.   NATURE IMMUNOLOGY

Differential Fc-Receptor Engagement Drives an Anti-tumor Vaccinal Effect

(2015) David J. DiLillo et al.   CELL

Anti-HA Glycoforms Drive B Cell Affinity Selection and Determine Influenza Vaccine Efficacy

(2015) Taia T. Wang et al.   CELL

DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance

(2015) Patricia Conde et al.   IMMUNITY

Skewed Fc Glycosylation Profiles of Anti-proteinase 3 Immunoglobulin G1 Autoantibodies from Granulomatosis with Polyangiitis Patients Show Low Levels of Bisection, Galactosylation, and Sialylation

(2015) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH

Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

(2015) Nathaniel Washburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Role of Antibody N-Glycosylation in Receptor Interactions

(2015) Ganesh P. Subedi et al.   STRUCTURE

Disease activity or remission of rheumatoid arthritis before, during and following pregnancy

(2014) Yael A. de Man et al.   CURRENT OPINION IN RHEUMATOLOGY

Human IgG Fc domain engineering enhances antitoxin neutralizing antibody activity

(2014) Stylianos Bournazos et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibitory Fc  Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms

(2014) F. Li et al.   JOURNAL OF IMMUNOLOGY

Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins

(2014) Alysia A. Ahmed et al.   JOURNAL OF MOLECULAR BIOLOGY

IgG Fc N-Glycosylation in Guillain–Barré Syndrome Treated with Immunoglobulins

(2014) Willem-Jan R. Fokkink et al.   JOURNAL OF PROTEOME RESEARCH

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Afucosylated Antibodies Increase Activation of Fc RIIIa-Dependent Signaling Components to Intensify Processes Promoting ADCC

(2014) S. D. Liu et al.   Cancer Immunology Research

A prominent lack of IgG1-Fc fucosylation of platelet alloantibodies in pregnancy

(2013) R. Kapur et al.   BLOOD

High-Throughput IgG Fc N-Glycosylation Profiling by Mass Spectrometry of Glycopeptides

(2013) Maja Pučić Baković et al.   JOURNAL OF PROTEOME RESEARCH

General mechanism for modulating immunoglobulin effector function

(2013) P. Sondermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Role of Glycosylation in the Structure of Human IgG Fc

(2012) M. Jack Borrok et al.   ACS Chemical Biology

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mouse model recapitulating human Fc  receptor structural and functional diversity

(2012) P. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI

(2012) B. Dhaliwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

(2011) Cécile Espy et al.   ARTHRITIS AND RHEUMATISM

Basis of the Intrinsic Flexibility of the Cε3 Domain of IgE

(2011) Susmita Borthakur et al.   BIOCHEMISTRY

Fc specific IgG glycosylation profiling by robust nano-reverse phase HPLC-MS using a sheath-flow ESI sprayer interface

(2011) Maurice H.J. Selman et al.   Journal of Proteomics

Changes in Antigen-specific IgG1 FcN-glycosylation Upon Influenza and Tetanus Vaccination

(2011) Maurice H. J. Selman et al.   MOLECULAR & CELLULAR PROTEOMICS

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Fc  Receptor Engagement Drives Adjuvant and Anti-Tumor Activities of Agonistic CD40 Antibodies

(2011) F. Li et al.   SCIENCE

Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid

(2010) Hans U. Scherer et al.   ARTHRITIS AND RHEUMATISM

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo

(2010) Robert M Anthony et al.   Current Opinion in Organ Transplantation

Impaired inhibitory Fc  receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy

(2009) B. Tackenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

(2009) Fleur E van de Geijn et al.   ARTHRITIS RESEARCH & THERAPY

Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens

(2008) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH

Identification of a receptor required for the anti-inflammatory activity of IVIG

(2008) R. M. Anthony et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE