PLCA8 suppresses breast cancer apoptosis by activating the PI3k/AKT/NF‐κB pathway

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth

(2018) Yunlu Jia et al.   Cell Death & Disease

Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence

(2018) Laura Vera-Ramirez et al.   Nature Communications

Tim-4 promotes the growth of colorectal cancer by activating angiogenesis and recruiting tumor-associated macrophages via the PI3K/AKT/mTOR signaling pathway

(2018) Xiao Tan et al.   CANCER LETTERS

New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ERα and downregulating PI3K/Akt-PKCα leading to caspase-dependent apoptosis

(2018) A. Arun et al.   CELL PROLIFERATION

WBP2 Downregulation Inhibits Proliferation by Blocking YAP Transcription and the EGFR/PI3K/Akt Signaling Pathway in Triple Negative Breast Cancer

(2018) Hongming Song et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Leptospermum flavescens Sm. protect pancreatic β cell function from streptozotocin involving apoptosis and autophagy signaling pathway in in vitro and in vivo case study

(2018) Ahmad Fadhlurrahman Ahmad Hidayat et al.   JOURNAL OF ETHNOPHARMACOLOGY

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

(2018) Ryan S. Soderquist et al.   Nature Communications

Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

(2018) Hong-Wei Zhang et al.   Scientific Reports

Overexpression of placenta specific 8 is associated with malignant progression and poor prognosis of clear cell renal cell carcinoma

(2017) Liping Shi et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

(2017) Eneda Toska et al.   SCIENCE

cPLA2α mediates TGF-β-induced epithelial–mesenchymal transition in breast cancer through PI3k/Akt signaling

(2017) Lu Chen et al.   Cell Death & Disease

Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer

(2017) S-U Woo et al.   Oncogenesis

Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3β/Wnt/β-catenin signaling

(2016) Lei Zou et al.   BIOMEDICINE & PHARMACOTHERAPY

Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells

(2016) Xinfeng Yu et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

(2016) William W Du et al.   CELL DEATH AND DIFFERENTIATION

Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage

(2016) Ansar Karimian et al.   DNA REPAIR

PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

(2015) B. P. Kaistha et al.   CANCER RESEARCH

New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats

(2015) Daiki Sasaki et al.   MAMMALIAN GENOME

Caspase-3 Promotes Genetic Instability and Carcinogenesis

(2015) Xinjian Liu et al.   MOLECULAR CELL

Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer

(2014) Cunxi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Long Noncoding RNA ANRIL Promotes Non-Small Cell Lung Cancer Cell Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression

(2014) F.-q. Nie et al.   MOLECULAR CANCER THERAPEUTICS

Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression

(2014) Conan Kinsey et al.   Cell Reports

Apoptosis Suppression by Candidate Oncogene PLAC8 is Reversed in Other Cell Types

(2012) Mirna Mourtada-Maarabouni et al.   CURRENT CANCER DRUG TARGETS

Plac8 Is an Inducer of C/EBPβ Required for Brown Fat Differentiation, Thermoregulation, and Control of Body Weight

(2011) Maria Jimenez-Preitner et al.   Cell Metabolism