New piperidine derivative DTPEP acts as dual-acting anti-breast cancer agent by targeting ERα and downregulating PI3K/Akt-PKCα leading to caspase-dependent apoptosis

Novel SERMs based on 3-aryl-4-aryloxy-2H-chromen-2-one skeleton - A possible way to dual ERα/VEGFR-2 ligands for treatment of breast cancer

(2017) Guoshun Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indole-coumarin-thiadiazole hybrids: An appraisal of their MCF-7 cell growth inhibition, apoptotic, antimetastatic and computational Bcl-2 binding potential

(2017) Pooja R. Kamath et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bivalent Approach for Homodimeric Estradiol Based Ligand: Synthesis and Evaluation for Targeted Theranosis of ER(+) Breast Carcinomas

(2016) Kanchan Chauhan et al.   BIOCONJUGATE CHEMISTRY

New orally active DNA minor groove binding small molecule CT-1 acts against breast cancer by targeting tumor DNA damage leading to p53-dependent apoptosis

(2016) Karan Singh Saini et al.   MOLECULAR CARCINOGENESIS

Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors

(2016) Kapil Upadhyaya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, synthesis and in vitro evaluation of coumarin–imidazo[1,2-a]pyridine derivatives against cancer induced osteoporosis

(2016) Koneni V. Sashidhara et al.   RSC Advances

Discovery of 3,4,6-Triaryl-2-pyridones as Potential Anticancer Agents that Promote ROS-Independent Mitochondrial-Mediated Apoptosis in Human Breast Carcinoma Cells

(2016) Mohammad Imran Ansari et al.   ChemistrySelect

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

(2015) Yaoxian Wang et al.   BMC CANCER

Synthesis of targeted dibenzo[b,f]thiepines and dibenzo[b,f]oxepines as potential lead molecules with promising anti-breast cancer activity

(2015) Mohd. Imran Ansari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models

(2015) Hamidullah et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway

(2015) HAIZHI HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer

(2015) Chu Tang et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand

(2014) Niamh M. O’Boyle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells

(2014) Mi-Young Lee et al.   Cell Division

PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9

(2013) Ying Ding et al.   APOPTOSIS

Sulphamoylated 2-Methoxyestradiol Analogues Induce Apoptosis in Adenocarcinoma Cell Lines

(2013) Michelle Visagie et al.   PLoS One

Estrogen and Cancer

(2012) Jing Liang et al.   Annual Review of Physiology

Phosphorylation of Estrogen Receptor α at Serine 118 Directs Recruitment of Promoter Complexes and Gene-Specific Transcription

(2011) Tamika T. Duplessis et al.   ENDOCRINOLOGY

Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative—Enhancement of both extrinsic and intrinsic apoptosis pathways

(2010) Anja Berger et al.   BIOCHEMICAL PHARMACOLOGY

Comparison of Fixation Methods for Preservation of Morphology, RNAs, and Proteins From Paraffin-Embedded Human Cancer Cell-Implanted Mouse Models

(2010) Yoko Matsuda et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Tamoxifen inhibits tumor cell invasion and metastasis in mouse melanoma through suppression of PKC/MEK/ERK and PKC/PI3K/Akt pathways

(2009) Hiroshi Matsuoka et al.   EXPERIMENTAL CELL RESEARCH

ERβ in breast cancer—Onlooker, passive player, or active protector?

(2008) Emily M. Fox et al.   STEROIDS