Force-generating mechanisms of anaphase in human cells

Kinesin-6 regulates cell-size-dependent spindle elongation velocity to keep mitosis duration constant in fission yeast

(2019) Lara Katharina Krüger et al.   eLife

High-resolution imaging reveals how the spindle midzone impacts chromosome movement

(2019) Melissa C. Pamula et al.   JOURNAL OF CELL BIOLOGY

Central spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B

(2019) Che-Hang Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Kinesin-6 KIF20B is required for efficient cytokinetic furrowing and timely abscission in human cells

(2018) Kerstin M. Janisch et al.   MOLECULAR BIOLOGY OF THE CELL

Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

(2018) Damian Dudka et al.   Nature Communications

Non-random Mis-segregation of Human Chromosomes

(2018) Joseph Thomas Worrall et al.   Cell Reports

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

(2018) Vladimir A Volkov et al.   eLife

Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles

(2017) Iva M. Tolić   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis

(2017) Faye M. Nixon et al.   JOURNAL OF CELL SCIENCE

Self-Organization and Forces in the Mitotic Spindle

(2016) Nenad Pavin et al.   Annual Review of Biophysics

Bridging the gap between sister kinetochores

(2016) Iva M. Tolić et al.   CELL CYCLE

Late mitotic functions of Aurora kinases

(2016) Olga Afonso et al.   CHROMOSOMA

PRC1‐labeled microtubule bundles and kinetochore pairs show one‐to‐one association in metaphase

(2016) Bruno Polak et al.   EMBO REPORTS

Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission

(2016) Ryota Uehara et al.   MOLECULAR BIOLOGY OF THE CELL

Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores

(2016) Janko Kajtez et al.   Nature Communications

A Regulatory Switch Alters Chromosome Motions at the Metaphase-to-Anaphase Transition

(2016) Kuan-Chung Su et al.   Cell Reports

Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules

(2015) Vladimir A. Volkov et al.   JOURNAL OF CELL BIOLOGY

Microtubule nucleation at the centrosome and beyond

(2015) Sabine Petry et al.   NATURE CELL BIOLOGY

Cytokinesis in Animal Cells

(2015) Pier Paolo D’Avino et al.   Cold Spring Harbor Perspectives in Biology

Dynein, microtubule and cargo: a ménage à trois

(2015) Nenad Pavin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Function and regulation of dynein in mitotic chromosome segregation

(2014) J. A. Raaijmakers et al.   CHROMOSOMA

Direct kinetochore–spindle pole connections are not required for chromosome segregation

(2014) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

Force on spindle microtubule minus ends moves chromosomes

(2014) Mary Williard Elting et al.   JOURNAL OF CELL BIOLOGY

Prime movers: the mechanochemistry of mitotic kinesins

(2014) Robert A. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Feedback control of chromosome separation by a midzone Aurora B gradient

(2014) O. Afonso et al.   SCIENCE

Balanced Activity of Three Mitotic Motors Is Required for Bipolar Spindle Assembly and Chromosome Segregation

(2014) Roy G.H.P. van Heesbeen et al.   Cell Reports

Dynein Motion Switches from Diffusive to Directed upon Cortical Anchoring

(2013) Vaishnavi Ananthanarayanan et al.   CELL

Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase

(2013) Tomomi Kiyomitsu et al.   CELL

NuMA phosphorylation dictates dynein-dependent spindle positioning

(2013) Sachin Kotak et al.   CELL CYCLE

Eg5 restricts anaphase B spindle elongation in mammalian cells

(2013) Elizabeth Collins et al.   Cytoskeleton

Nonautonomous Movement of Chromosomes in Mitosis

(2013) Elina Vladimirou et al.   DEVELOPMENTAL CELL

NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function

(2013) Sachin Kotak et al.   EMBO JOURNAL

Aurora A kinase and its substrate TACC3 are required for central spindle assembly

(2013) Antonios Lioutas et al.   EMBO REPORTS

Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation

(2013) Haifeng Wang et al.   JOURNAL OF CELL BIOLOGY

Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued

(2013) David Reboutier et al.   JOURNAL OF CELL BIOLOGY

The KMN protein network - chief conductors of the kinetochore orchestra

(2013) D. Varma et al.   JOURNAL OF CELL SCIENCE

Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control

(2013) Xiaolei Su et al.   NATURE CELL BIOLOGY

Effect of Cell Shape and Dimensionality on Spindle Orientation and Mitotic Timing

(2013) Mirren Charnley et al.   PLoS One

Cortical Dynein Controls Microtubule Dynamics to Generate Pulling Forces that Position Microtubule Asters

(2012) Liedewij Laan et al.   CELL

Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis

(2012) Suranjana Mukherjee et al.   CELL CYCLE

Anaphase B Precedes Anaphase A in the Mouse Egg

(2012) Greg FitzHarris   CURRENT BIOLOGY

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments

(2012) Jens C. Schmidt et al.   DEVELOPMENTAL CELL

Aster migration determines the length scale of nuclear separation in theDrosophilasyncytial embryo

(2012) Ivo A. Telley et al.   JOURNAL OF CELL BIOLOGY

Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis

(2012) Cornelia Wandke et al.   JOURNAL OF CELL BIOLOGY

Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis

(2012) Chi-Kuo Hu et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation

(2012) Tomomi Kiyomitsu et al.   NATURE CELL BIOLOGY

Biophysics of mitosis

(2012) J. Richard McIntosh et al.   QUARTERLY REVIEWS OF BIOPHYSICS

KIF4 Regulates Midzone Length during Cytokinesis

(2011) Chi-Kuo Hu et al.   CURRENT BIOLOGY

Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

(2011) Nadia Hégarat et al.   JOURNAL OF CELL BIOLOGY

Phosphatases: providing safe passage through mitotic exit

(2011) Claudia Wurzenberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic Spindle Orients Perpendicular to the Forces Imposed by Dynamic Shear

(2011) Pablo Fernandez et al.   PLoS One

Cell cycle control of spindle elongation

(2010) Johanna Roostalu et al.   CELL CYCLE

The perpetual movements of anaphase

(2010) Helder Maiato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Finding the middle ground: how kinetochores power chromosome congression

(2010) Geert J. P. L. Kops et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitotic force generators and chromosome segregation

(2010) Gul Civelekoglu-Scholey et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

THE MECHANISM OF CO-ORIENTATION IN BIVALENTS AND MULTIVALENTS

(2010) GUNNAR ÖSTERGREN   HEREDITAS

Tubulin depolymerization may be an ancient biological motor

(2010) J. R. McIntosh et al.   JOURNAL OF CELL SCIENCE

A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis

(2010) Julien Dumont et al.   NATURE CELL BIOLOGY

Dynein at the kinetochore: Timing, Interactions and Functions

(2010) Jason R. Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

(2009) Andrew F. Powers et al.   CELL

Motor-Independent Targeting of CLASPs to Kinetochores by CENP-E Promotes Microtubule Turnover and Poleward Flux

(2009) Stefano Maffini et al.   CURRENT BIOLOGY

Kif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly

(2009) Marvin E. Tanenbaum et al.   CURRENT BIOLOGY

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

(2009) Steffen Lawo et al.   CURRENT BIOLOGY

The Human Kinetochore Ska1 Complex Facilitates Microtubule Depolymerization-Coupled Motility

(2009) Julie P.I. Welburn et al.   DEVELOPMENTAL CELL

Phospho-Regulated Interaction between Kinesin-6 Klp9p and Microtubule Bundler Ase1p Promotes Spindle Elongation

(2009) Chuanhai Fu et al.   DEVELOPMENTAL CELL

PRC1 Cooperates with CLASP1 to Organize Central Spindle Plasticity in Mitosis

(2009) Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinesin-5–dependent Poleward Flux and Spindle Length Control in Drosophila Embryo Mitosis

(2009) Ingrid Brust-Mascher et al.   MOLECULAR BIOLOGY OF THE CELL

Traffic control: regulation of kinesin motors

(2009) Kristen J. Verhey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells

(2009) R. Uehara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrils Connect Microtubule Tips with Kinetochores: A Mechanism to Couple Tubulin Dynamics to Chromosome Motion

(2008) J. Richard McIntosh et al.   CELL

The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment

(2008) Jason Stumpff et al.   DEVELOPMENTAL CELL

Kinesin-8 from Fission Yeast: A Heterodimeric, Plus-End–directed Motor that Can Couple Microtubule Depolymerization to Cargo Movement

(2008) Paula M. Grissom et al.   MOLECULAR BIOLOGY OF THE CELL

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY