Checkpoint signaling and error correction require regulation of the MPS1 T-loop by PP2A-B56

CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

(2019) Daniel Hayward et al.   JOURNAL OF CELL BIOLOGY

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

(2019) Tatiana Alfonso-Pérez et al.   JOURNAL OF CELL BIOLOGY

Division of labour between PP2A-B56 isoforms at the centromere and kinetochore

(2019) Giulia Vallardi et al.   eLife

Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint

(2018) Guillaume Combes et al.   CURRENT BIOLOGY

Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

(2018) Spyridon T. Pachis et al.   Open Biology

PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors

(2017) Meng S. Choy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint

(2017) Junbin Qian et al.   MOLECULAR CELL

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Micromanaging checkpoint proteins

(2017) Andrea Ciliberto et al.   eLife

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

(2017) Margarida Moura et al.   eLife

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing

(2014) Antonio Espert et al.   JOURNAL OF CELL BIOLOGY

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

(2014) Xinghui Wang et al.   PLoS One

The structural mechanisms that underpin mitotic kinase activation

(2013) Charlotte A. Dodson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

4D-networking by mitotic phosphatases

(2013) Junbin Qian et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore

(2013) Tongge Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B

(2013) Wilco Nijenhuis et al.   JOURNAL OF CELL BIOLOGY

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

(2013) P. Xu et al.   Biology Open

The MPS1 Family of Protein Kinases

(2012) Xuedong Liu et al.   Annual Review of Biochemistry

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment

(2011) Anja K. Dunsch et al.   JOURNAL OF CELL BIOLOGY

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

(2011) Zhen Dou et al.   PLoS One

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores

(2010) Jens C. Schmidt et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2

(2010) Kang Zeng et al.   JOURNAL OF CELL BIOLOGY

Phosphoregulation of human Mps1 kinase

(2008) Rebecca K. Tyler et al.   BIOCHEMICAL JOURNAL

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

(2008) Nannette Jelluma et al.   PLoS One