Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer

Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial

(2019) Salah-Eddin Al-Batran et al.   LANCET

MiR-876-5p regulates gastric cancer cell proliferation, apoptosis and migration through targeting WNT5A and MITF

(2019) Zhenglei Xu et al.   BIOSCIENCE REPORTS

A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production

(2019) Mostafa F. ElMaghraby et al.   CELL

Rates of TP53 Mutation are Significantly Elevated in African American Patients with Gastric Cancer

(2018) Elke J. A. H. van Beek et al.   ANNALS OF SURGICAL ONCOLOGY

Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma

(2018) Ujjawal H. Gandhi et al.   Clinical Lymphoma Myeloma & Leukemia

Germline CDH1 mutations are a significant contributor to the high frequency of early-onset diffuse gastric cancer cases in New Zealand Māori

(2018) Christopher Hakkaart et al.   Familial Cancer

The XPO1 Inhibitor Selinexor Inhibits Translation and Enhances the Radiosensitivity of Glioblastoma Cells GrownIn VitroandIn Vivo

(2018) Amy Wahba et al.   MOLECULAR CANCER THERAPEUTICS

Comparative Molecular Analyses of Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, and Gastric Adenocarcinoma

(2018) Mohamed E. Salem et al.   ONCOLOGIST

Selinexor reduces the expression of DNA damage repair proteins and sensitizes cancer cells to DNA damaging agents

(2018) Trinayan Kashyap et al.   Oncotarget

TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia

(2018) Hilary C. Archbold et al.   Scientific Reports

The Role of Exportin-5 in MicroRNA Biogenesis and Cancer

(2018) Ke Wu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Lifestyle chemical carcinogens associated with mutations in cell cycle regulatory genes increases the susceptibility to gastric cancer risk

(2018) Ravi Prakash Yadav et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer

(2018) Joana Figueiredo et al.   Molecular Cancer

Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

(2018) Vinod Vijay Subhash et al.   Scientific Reports

Isolation of spheroid-forming single cells from gastric cancer cell lines: enrichment of cancer stem-like cells

(2018) Jong Won Lee et al.   BIOTECHNIQUES

Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS

(2018) Wei Zhuo et al.   GASTROENTEROLOGY

Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer

(2017) Arjun Gupta et al.   Journal of Thoracic Oncology

Exportin 1 (XPO1) inhibition leads to restoration of tumor suppressor miR-145 and consequent suppression of pancreatic cancer cell proliferation and migration

(2017) Asfar S. Azmi et al.   Oncotarget

Anti-tumor activity of selective inhibitor of nuclear export (SINE) compounds, is enhanced in non-Hodgkin lymphoma through combination with mTOR inhibitor and dexamethasone

(2016) Irfana Muqbil et al.   CANCER LETTERS

Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer

(2016) Ying Chen et al.   CLINICAL CANCER RESEARCH

Mechanisms for the induction of gastric cancer by Helicobacter pylori infection: aberrant DNA methylation pathway

(2016) Masahiro Maeda et al.   Gastric Cancer

Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia

(2016) Thomas B. Alexander et al.   JOURNAL OF CLINICAL ONCOLOGY

Gastric Cancer, Version 3.2016, NCCN Clinical Practice Guidelines in Oncology

(2016) Jaffer A. Ajani et al.   Journal of the National Comprehensive Cancer Network

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

(2016) Z A Hing et al.   LEUKEMIA

Strahlensensibilität durch Inhibition von XPO1 in Zelllinien kolorektaler Karzinome gesteigert

(2016) Moritz von Fallois et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death

(2016) Trinayan Kashyap et al.   Oncotarget

XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma

(2016) Joel G. Turner et al.   Oncotarget

An atlas of gastric PIWI-interacting RNA transcriptomes and their utility for identifying signatures of gastric cancer recurrence

(2015) Victor D. Martinez et al.   Gastric Cancer

RAN Nucleo-Cytoplasmic Transport and Mitotic Spindle Assembly Partners XPO7 and TPX2 Are New Prognostic Biomarkers in Serous Epithelial Ovarian Cancer

(2014) Katia Y. Cáceres-Gorriti et al.   PLoS One

Non-coding RNAs and gastric cancer

(2014) Pei-Fei Li   WORLD JOURNAL OF GASTROENTEROLOGY

Helicobacter pylori eradication therapy to prevent gastric cancer in healthy asymptomatic infected individuals: systematic review and meta-analysis of randomised controlled trials

(2014) A. C. Ford et al.   BMJ-British Medical Journal

Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs

(2014) Baoyan Bai et al.   FEBS Open Bio

Nuclear Export Mediated Regulation of MicroRNAs: Potential Target for Drug Intervention

(2013) Irfana Muqbil et al.   CURRENT DRUG TARGETS

Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice

(2012) Asfar S. Azmi et al.   GASTROENTEROLOGY

Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells

(2012) YUNG HYUN CHOI et al.   ONCOLOGY REPORTS

Epstein-Barr Virus (EBV)-associated Gastric Carcinoma

(2012) Hisashi Iizasa et al.   Viruses-Basel

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila

(2010) Ingo Büssing et al.   EMBO JOURNAL

Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands

(2009) Lisette G. Capelle et al.   GASTROENTEROLOGY