Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents

The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix

(2019) Daniel Passos da Silva et al.   Nature Communications

Corrosion Motivated ROS Generation Helps Endow Titanium with Broad‐Spectrum Antibacterial Abilities

(2019) Donghui Wang et al.   Advanced Materials Interfaces

Rational design of genetically encoded singlet oxygen photosensitizing proteins

(2019) Michael Westberg et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Porphyrinoid photosensitizers mediated photodynamic inactivation against bacteria

(2019) Lukasz Sobotta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Lectin-Functionalized Composite Hydrogels for “Capture-and-Killing” of Carbapenem-Resistant Pseudomonas aeruginosa

(2018) Nicholas Bodenberger et al.   BIOMACROMOLECULES

Optogenetic Control by Pulsed Illumination

(2018) Julia Hennemann et al.   CHEMBIOCHEM

Light-induced oxidant production by fluorescent proteins

(2018) Adam J. Trewin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery and development of new antibacterial drugs: learning from experience?

(2018) Nicole Jackson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Can light-based approaches overcome antimicrobial resistance?

(2018) Michael R. Hamblin et al.   DRUG DEVELOPMENT RESEARCH

A proton transfer network that generates deprotonated tyrosine is a key to producing reactive oxygen species in phototoxic KillerRed protein

(2018) Wook Lee et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

An optogenetic toolbox of LOV-based photosensitizers for light-driven killing of bacteria

(2018) Stephan Endres et al.   Scientific Reports

Monodisperse Sequence‐Controlled α‐ l ‐Fucosylated Glycooligomers and Their Multivalent Inhibitory Effects on LecB

(2018) Katharina Susanne Bücher et al.   MACROMOLECULAR BIOSCIENCE

No Photon Wasted: An Efficient and Selective Singlet Oxygen Photosensitizing Protein

(2017) Michael Westberg et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Photoantimicrobials—are we afraid of the light?

(2017) Mark Wainwright et al.   LANCET INFECTIOUS DISEASES

Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation

(2016) Catherine Cott et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antimicrobial photodynamic inactivation: a bright new technique to kill resistant microbes

(2016) Michael R Hamblin   CURRENT OPINION IN MICROBIOLOGY

Applications of genetically encoded photosensitizer miniSOG: from correlative light electron microscopy to immunophotosensitizing

(2016) Ekaterina A. Souslova et al.   Journal of Biophotonics

Gram positive and Gram negative bacteria differ in their sensitivity to cold plasma

(2016) Anne Mai-Prochnow et al.   Scientific Reports

Rapid inoculation of single bacteria into parallel picoliter fermentation chambers

(2015) Christopher Probst et al.   Analytical Methods

Drug Resistance in Mycobacterium tuberculosis

(2015) Paolo Miotto et al.   CHEST

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform

(2015) Alexander Grünberger et al.   CYTOMETRY PART A

Resistance in antimicrobial photodynamic inactivation of bacteria

(2015) Tim Maisch   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

KillerOrange, a Genetically Encoded Photosensitizer Activated by Blue and Green Light

(2015) Karen S. Sarkisyan et al.   PLoS One

Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG

(2014) Dennis Binder et al.   Integrative Biology

The photophysics of LOV-based fluorescent proteins – new tools for cell biology

(2014) Marcus Wingen et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Flavoprotein miniSOG as a genetically encoded photosensitizer for cancer cells

(2013) Alina P. Ryumina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A genetically-encoded KillerRed protein as an intrinsically generated photosensitizer for photodynamic therapy

(2013) Zi-Xian Liao et al.   BIOMATERIALS

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin

(2013) Li Lan et al.   NUCLEIC ACIDS RESEARCH

SuperNova, a monomeric photosensitizing fluorescent protein for chromophore-assisted light inactivation

(2013) Kiwamu Takemoto et al.   Scientific Reports

Genetically Encoded Immunophotosensitizer 4D5scFv-miniSOG is a Highly Selective Agent for Targeted Photokilling of Tumor Cells in Vitro

(2013) Kristina E. Mironova et al.   Theranostics

Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

(2013) Alexander Gruenberger et al.   Jove-Journal of Visualized Experiments

Photodynamic Therapy for Cancer and for Infections: What Is the Difference?

(2012) Sulbha K. Sharma et al.   ISRAEL JOURNAL OF CHEMISTRY

Phototoxic effects of fluorescent protein KillerRed on tumor cells in mice

(2012) Marina V. Shirmanova et al.   Journal of Biophotonics

Fast and effective: intense pulse light photodynamic inactivation of bacteria

(2012) Tim Maisch et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Deleterious effects of mitochondrial ROS generated by KillerRed photodynamic action in human cell lines and C. elegans

(2012) Toshiharu Shibuya et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Type I and Type II mechanisms of antimicrobial photodynamic therapy: An in vitro study on gram-negative and gram-positive bacteria

(2012) Liyi Huang et al.   LASERS IN SURGERY AND MEDICINE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Light-induced blockage of cell division with a chromatin-targeted phototoxic fluorescent protein

(2011) Ekaterina O. Serebrovskaya et al.   BIOCHEMICAL JOURNAL

Reactive oxygen species in photochemistry of the red fluorescent protein “Killer Red”

(2011) Russell B. Vegh et al.   CHEMICAL COMMUNICATIONS

Singlet Oxygen’s Response to Protein Dynamics

(2011) Rasmus Lybech Jensen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

All you need is light

(2011) Tyler G St. Denis et al.   Virulence

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

(2011) Xiaokun Shu et al.   PLOS BIOLOGY

Stable Synthetic Cationic Bacteriochlorins as Selective Antimicrobial Photosensitizers

(2010) L. Huang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Does Cellular Hydrogen Peroxide Diffuse or Act Locally?

(2010) Natalia M. Mishina et al.   ANTIOXIDANTS & REDOX SIGNALING

Singlet oxygen: there is indeed something new under the sun

(2010) Peter R. Ogilby   CHEMICAL SOCIETY REVIEWS

β1A Integrin Is a Master Regulator of Invadosome Organization and Function

(2010) Olivier Destaing et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis for Phototoxicity of the Genetically Encoded Photosensitizer KillerRed

(2009) Sergei Pletnev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photodynamic therapy (PDT): A short review on cellular mechanisms and cancer research applications for PDT

(2009) C.A. Robertson et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Staphylococcus epidermidis — the 'accidental' pathogen

(2009) Michael Otto   NATURE REVIEWS MICROBIOLOGY

Targeting cancer cells by using an antireceptor antibody-photosensitizer fusion protein

(2009) E. O. Serebrovskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA