Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer

A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers

(2018) Shoumin Zhu et al.   CLINICAL CANCER RESEARCH

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells

(2017) Annapina Russo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of GLI1 for 5-Fu resistance in colorectal cancer

(2017) Lining Zhang et al.   Cell and Bioscience

Sorafenib and Quinacrine Target Anti-Apoptotic Protein MCL1: A Poor Prognostic Marker in Anaplastic Thyroid Cancer (ATC)

(2016) J. Abdulghani et al.   CLINICAL CANCER RESEARCH

ABT-888 and quinacrine induced apoptosis in metastatic breast cancer stem cells by inhibiting base excision repair via adenomatous polyposis coli

(2016) Sumit Siddharth et al.   DNA REPAIR

The Dual Roles of NRF2 in Cancer

(2016) Silvia Menegon et al.   TRENDS IN MOLECULAR MEDICINE

NQO1 inhibits proteasome-mediated degradation of HIF-1α

(2016) Eun-Taex Oh et al.   Nature Communications

5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53

(2016) Valentina Pagliara et al.   Oncotarget

Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia

(2016) Eun-Taex Oh et al.   Scientific Reports

rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment

(2016) Annapina Russo et al.   Scientific Reports

Quinacrine sterilization (QS): time for reconsideration

(2015) Jack Lippes   CONTRACEPTION

Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression

(2015) Jung-Jung Changchien et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

(2015) Upadhyayula Sai Srinivas et al.   Oncotarget

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer

(2014) Xiu-Feng Hu et al.   Asian Pacific Journal of Cancer Prevention

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Quinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, NF- B, and Cell-Cycle Progression in Non-Small Cell Lung Cancer

(2014) J. K. T. Dermawan et al.   MOLECULAR CANCER THERAPEUTICS

Baicalein reverses hypoxia-induced 5-FU resistance in gastric cancer AGS cells through suppression of glycolysis and the PTEN/Akt/HIF-1α signaling pathway

(2014) FENGLIN CHEN et al.   ONCOLOGY REPORTS

Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation

(2014) K A Kang et al.   Cell Death & Disease

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Blockage of Nrf2 suppresses the migration and invasion of esophageal squamous cell carcinoma cells in hypoxic microenvironment

(2013) H. Shen et al.   DISEASES OF THE ESOPHAGUS

Identification of UV-protective Activators of Nuclear Factor Erythroid-derived 2-Related Factor 2 (Nrf2) by Combining a Chemical Library Screen with Computer-based Virtual Screening

(2012) Franziska Lieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer

(2011) Jean-Nicolas Gallant et al.   CANCER BIOLOGY & THERAPY

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 

(2011) T.-H. Kim et al.   CANCER RESEARCH

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity

(2011) Ranjan Preet et al.   INTERNATIONAL JOURNAL OF CANCER

5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

(2010) K Bracht et al.   BRITISH JOURNAL OF CANCER

Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil

(2009) Raffaella Ravizza et al.   EUROPEAN JOURNAL OF CANCER

Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells

(2009) Hanane Akhdar et al.   EUROPEAN JOURNAL OF CANCER

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents

(2009) Katerina Gurova   Future Oncology

HIF-1α is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy

(2009) Jun Nakamura et al.   INTERNATIONAL JOURNAL OF CANCER

9-Aminoacridine-based anticancer drugs target the PI3K/AKT/mTOR, NF-κB and p53 pathways

(2009) C Guo et al.   ONCOGENE

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

(2009) Zheng Sun et al.   PLoS One

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

(2008) T. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA