Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for Therapy

Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma – MCT1 as potential target in diffuse large B cell lymphoma

(2019) Julieta Afonso et al.   CELLULAR ONCOLOGY

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T cell efficacy

(2019) Jaco A. C. van Bruggen et al.   BLOOD

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

Pegaspargase: A Review in Acute Lymphoblastic Leukaemia

(2019) Young-A. Heo et al.   DRUGS

CSF1R and BTK inhibitions as novel strategies to disrupt the dialog between mantle cell lymphoma and macrophages

(2019) Antonin Papin et al.   LEUKEMIA

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

(2019) Liang Zhang et al.   Science Translational Medicine

The multifaceted effects of metformin on tumor microenvironment

(2019) Ivana Kurelac et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of lymphoma clearance induced by high-dose alkylating agents

(2019) Chen Lossos et al.   Cancer Discovery

Coordinate Modulation of Glycolytic Enzymes and OXPHOS by Imatinib in BCR-ABL Driven Chronic Myelogenous Leukemia Cells

(2019) Viviana De Rosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting tumor-associated acidity in cancer immunotherapy

(2018) Ruben Lacroix et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

(2018) Gang Xiao et al.   CELL

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesis

(2018) Marco Fischer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity

(2018) Mohamad El-Zaatari et al.   GASTROENTEROLOGY

Ibrutinib inhibits free fatty acid metabolism in chronic lymphocytic leukemia

(2018) Uri Rozovski et al.   LEUKEMIA & LYMPHOMA

Reversal of indoleamine 2,3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme

(2018) Todd A Triplett et al.   NATURE BIOTECHNOLOGY

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia

(2018) Carmen D. Herling et al.   Nature Communications

Del11q-positive CLL lymphocytes exhibit altered glutamine metabolism and differential response to GLS1 and glucose metabolism inhibition

(2018) Gabriela Galicia-Vázquez et al.   Blood Cancer Journal

Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response

(2018) Felipe V. Pereira et al.   Oncotarget

Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma

(2018) Xiaoxiao Wang et al.   NEOPLASIA

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Ibrutinib Resistance Is Reduced by an Inhibitor of Fatty Acid Oxidation in Primary CLL Lymphocytes

(2018) Gabriela Galicia-Vázquez et al.   Frontiers in Oncology

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Potent anti‐proliferative effect of fatty‐acid derivative AIC ‐47 on leukemic mice harboring BCR ‐ ABL mutation

(2018) Haruka Shinohara et al.   CANCER SCIENCE

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells

(2018) Akihiko Sakamoto et al.   CANCER SCIENCE

Targeting Cancer Cells and Tumor Microenvironment in Preclinical and Clinical Models of Hodgkin Lymphoma Using the Dual PI3Kδ/γ Inhibitor RP6530

(2018) Silvia L. Locatelli et al.   CLINICAL CANCER RESEARCH

Mannose impairs tumour growth and enhances chemotherapy

(2018) Pablo Sierra Gonzalez et al.   NATURE

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Metabolic Reprogramming of Non-Hodgkin's B-Cell Lymphomas and Potential Therapeutic Strategies

(2018) Jean-Ehrland Ricci et al.   Frontiers in Oncology

Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies

(2017) Johann Pötzl et al.   INTERNATIONAL JOURNAL OF CANCER

Ibrutinib treatment improves T cell number and function in CLL patients

(2017) Meixiao Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability

(2017) Martina Broecker-Preuss et al.   Journal of Translational Medicine

EMMPRIN (CD147) is induced by C/EBPβ and is differentially expressed in ALK+ and ALK− anaplastic large-cell lymphoma

(2017) Janine Schmidt et al.   LABORATORY INVESTIGATION

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

(2017) A Chaturvedi et al.   LEUKEMIA

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia

(2017) Rupert L. Mayer et al.   MOLECULAR & CELLULAR PROTEOMICS

B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia

(2017) Hima V. Vangapandu et al.   MOLECULAR CANCER RESEARCH

Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma

(2017) Jeffrey Weber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment

(2017) Lekha Mikkilineni et al.   SEMINARS IN ONCOLOGY

Checkpoint Inhibition in Hodgkin Lymphoma - a Review

(2017) Paul J. Bröckelmann et al.   Oncology Research and Treatment

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Serum lactate dehydrogenase as an early marker for outcome in patients treated with anti-PD-1 therapy in metastatic melanoma

(2016) S Diem et al.   BRITISH JOURNAL OF CANCER

Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells

(2016) Haruka Shinohara et al.   CANCER LETTERS

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

(2016) Noga Ron-Harel et al.   Cell Metabolism

The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma

(2016) M. Ruella et al.   CLINICAL CANCER RESEARCH

Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab

(2016) Benjamin Weide et al.   CLINICAL CANCER RESEARCH

The emerging role of immune checkpoint inhibition in malignant lymphoma

(2016) Ida Hude et al.   HAEMATOLOGICA

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia

(2016) Peter J. Siska et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate

(2016) A Chaturvedi et al.   LEUKEMIA

Monodispersed calcium carbonate nanoparticles modulate local pH and inhibit tumor growth in vivo

(2016) Avik Som et al.   Nanoscale

Emetine elicits apoptosis of intractable B-cell lymphoma cells with MYC rearrangement through inhibition of glycolytic metabolism

(2016) Tomohiro Aoki et al.   Oncotarget

CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis

(2016) Xiaoyan Xin et al.   Scientific Reports

The emerging role of immune checkpoint inhibition in malignant lymphoma

(2016) Ida Hude et al.   HAEMATOLOGICA

Prognostic role of lactate dehydrogenase in solid tumors: A systematic review and meta-analysis of 76 studies

(2015) Fausto Petrelli et al.   ACTA ONCOLOGICA

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

(2015) F. McClanahan et al.   BLOOD

Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma

(2015) I. Sagiv-Barfi et al.   BLOOD

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Interactions between Ibrutinib and Anti-CD20 Antibodies: Competing Effects on the Outcome of Combination Therapy

(2015) M. Skarzynski et al.   CLINICAL CANCER RESEARCH

Metabolism pathways in chronic lymphocytic leukemia

(2015) Uri Rozovski et al.   LEUKEMIA & LYMPHOMA

Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells

(2015) U. Rozovski et al.   MOLECULAR CANCER RESEARCH

Mutations driving CLL and their evolution in progression and relapse

(2015) Dan A. Landau et al.   NATURE

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

(2015) Jessica Okosun et al.   NATURE GENETICS

Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

(2015) Steven M Chan et al.   NATURE MEDICINE

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters

(2015) L Gan et al.   ONCOGENE

Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells

(2015) Kamila Anna Zub et al.   PLoS One

Immune-mediated antitumor effect by type 2 diabetes drug, metformin

(2015) Shingo Eikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

(2015) Idit Sagiv-Barfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH

(2015) K Oizel et al.   Cell Death & Disease

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

(2015) A. J. Gunderson et al.   Cancer Discovery

Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells

(2015) Gayathri Natarajan et al.   OncoImmunology

Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia

(2014) L. Falchi et al.   BLOOD

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

Ibrutinib antagonizes rituximab-dependent NK cell-mediated cytotoxicity

(2014) H. E. Kohrt et al.   BLOOD

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

(2014) Ji-Young Choe et al.   BMC CANCER

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

(2014) A. R. Grassian et al.   CANCER RESEARCH

Sensitizing Protective Tumor Microenvironments to Antibody-Mediated Therapy

(2014) Christian P. Pallasch et al.   CELL

shRNA-Mediated EMMPRIN Silencing Inhibits Human Leukemic Monocyte Lymphoma U937 Cell Proliferation and Increases Chemosensitivity to Adriamycin

(2014) Hui Gao et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Targeting the Metabolic Plasticity of Multiple Myeloma with FDA-Approved Ritonavir and Metformin

(2014) S. Dalva-Aydemir et al.   CLINICAL CANCER RESEARCH

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

(2014) F. D. Roit et al.   HAEMATOLOGICA

Assessment of Tumor Size Reduction Improves Outcome Prediction of Positron Emission Tomography/Computed Tomography After Chemotherapy in Advanced-Stage Hodgkin Lymphoma

(2014) Carsten Kobe et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin’s lymphoma

(2014) Z-Z Yang et al.   LEUKEMIA

Investigating and targeting chronic lymphocytic leukemia metabolism with the human immunodeficiency virus protease inhibitor ritonavir and metformin

(2014) Kehinde U. A. Adekola et al.   LEUKEMIA & LYMPHOMA

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

(2014) Khaled Ali et al.   NATURE

PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma

(2014) Ajay K. Gopal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alteration of the lipid profile in lymphomas induced by MYC overexpression

(2014) L. S. Eberlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

(2014) M. R. Corces-Zimmerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues

(2014) I. Theate et al.   Cancer Immunology Research

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Role of aryl hydrocarbon receptor in cancer

(2013) Shaolong Feng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

(2013) J. A. Dubovsky et al.   BLOOD

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

PD-1 Increases PTEN Phosphatase Activity While Decreasing PTEN Protein Stability by Inhibiting Casein Kinase 2

(2013) Nikolaos Patsoukis et al.   MOLECULAR AND CELLULAR BIOLOGY

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

(2013) F. Wang et al.   SCIENCE

The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state

(2012) E. Tili et al.   BLOOD

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

(2012) Sylvia Hartmann et al.   BMC CANCER

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

(2012) Anne Le et al.   Cell Metabolism

Prolonged Production of Reactive Oxygen Species in Response to B Cell Receptor Stimulation Promotes B Cell Activation and Proliferation

(2012) Matthew L. Wheeler et al.   JOURNAL OF IMMUNOLOGY

First-line imatinib mesylate in patients with newly diagnosed accelerated phase-chronic myeloid leukemia

(2012) D Rea et al.   LEUKEMIA

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

(2012) Keisuke Ito et al.   NATURE MEDICINE

Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition

(2011) J. L. Coloff et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry

(2011) Fionnuala Morrish et al.   CELL CYCLE

Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival

(2011) Jonathan R. Brody et al.   CELL CYCLE

Expansion of a CD8+PD-1+ Replicative Senescence Phenotype in Early Stage CLL Patients Is Associated with Inverted CD4:CD8 Ratios and Disease Progression

(2011) C. Nunes et al.   CLINICAL CANCER RESEARCH

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance

(2011) P. Jain et al.   HAEMATOLOGICA

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

PI3K  Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic

(2011) D. A. Fruman et al.   Cancer Discovery

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

(2010) P. Perez-Galan et al.   BLOOD

Clinical significance of B7-H1（PD-L1）expression in human acute leukemia

(2010) Xiangli Chen et al.   CANCER BIOLOGY & THERAPY

An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells

(2010) J. D. Mezrich et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Exploring mammalian target of rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies

(2010) Bertrand Coiffier et al.   LEUKEMIA & LYMPHOMA

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species

(2010) Melania Capasso et al.   NATURE IMMUNOLOGY

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia

(2009) L. B. Silverman et al.   BLOOD

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

(2009) Ismael Samudio et al.   JOURNAL OF CLINICAL INVESTIGATION

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor  B

(2009) C. Porta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase

(2008) Christoph F.A. Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade

(2008) Christian P. Pallasch et al.   LEUKEMIA RESEARCH

Indoleamine 2,3-dioxygenase activity of acute myeloid leukemia cells can be measured from patients’ sera by HPLC and is inducible by IFN-γ

(2008) Selim Corm et al.   LEUKEMIA RESEARCH

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Global Regulation of Nucleotide Biosynthetic Genes by c-Myc

(2008) Yen-Chun Liu et al.   PLoS One

Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis

(2008) R. Brooks Robey et al.   SEMINARS IN CANCER BIOLOGY