Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis

Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis

(2017) Takashi Yamashita et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sorafenib exerts an anti-keloid activity by antagonizing TGF-β/Smad and MAPK/ERK signaling pathways

(2016) Wenbo Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Autophagy mediates oral submucous fibrosis

(2016) JIANG LI et al.   Experimental and Therapeutic Medicine

Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts

(2015) In Sik Yun et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis

(2015) Ruiguang Zhang et al.   TUMOR BIOLOGY

Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts

(2015) Jung U Shin et al.   YONSEI MEDICAL JOURNAL

Keloids and Hypertrophic Scars

(2014) OSMAN KÖSE et al.   DERMATOLOGIC SURGERY

Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease

(2014) Anna Alisi et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Inhibition of high-mobility group box 1 improves myocardial fibrosis and dysfunction in diabetic cardiomyopathy

(2014) Wen-ke Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Glycyrrhetinic Acid Triggers a Protective Autophagy by Activation of Extracellular Regulated Protein Kinases in Hepatocellular Carcinoma Cells

(2014) Zheng-Hai Tang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Emerging role of HMGB1 in fibrotic diseases

(2014) Liu-Cheng Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

(2014) Gu Gong et al.   PLoS One

HMGB1 in Cancer: Good, Bad, or Both?

(2013) R. Kang et al.   CLINICAL CANCER RESEARCH

Proteomic Profiling Reveals Upregulated Protein Expression of Hsp70 in Keloids

(2013) Ju Hee Lee et al.   Biomed Research International

Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars

(2012) Ji-Hong Shi et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

The Role of Glycyrrhizin, an Inhibitor of HMGB1 Protein, in Anticancer Therapy

(2012) Ryszard Smolarczyk et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

(2012) Wiem Chaabane et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Targeting HMGB1-mediated autophagy as a novel therapeutic strategy for osteosarcoma

(2012) Jun Huang et al.   Autophagy

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: Modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression

(2012) Chuan-tao Tu et al.   FOOD AND CHEMICAL TOXICOLOGY

A novel three-dimensional model system for keloid study: Organotypic multicellular scar model

(2012) Won Jai Lee et al.   WOUND REPAIR AND REGENERATION

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

HMGB1 inhibitor glycyrrhizin attenuates intracerebral hemorrhage-induced injury in rats

(2011) Masatoshi Ohnishi et al.   NEUROPHARMACOLOGY

The redox protein HMGB1 regulates cell death and survival in cancer treatment

(2010) Daolin Tang et al.   Autophagy

HMGB1: A novel Beclin 1-binding protein active in autophagy

(2010) Rui Kang et al.   Autophagy

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

Autophagy basics

(2010) Isei Tanida   MICROBIOLOGY AND IMMUNOLOGY

Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment?

(2010) Ayse Albayrak et al.   VIRAL IMMUNOLOGY

Keloids: Current concepts of pathogenesis (Review)

(2009) Bran   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Differential apoptosis markers in human keloids and hypertrophic scars fibroblasts

(2009) Bruna De Felice et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Potential Role of High-Mobility Group Box 1 in Cystic Fibrosis Airway Disease

(2008) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Role of High Mobility Group Box1 in Pulmonary Fibrosis

(2008) Naoki Hamada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Short hairpin RNA-expressing oncolytic adenovirus-mediated inhibition of IL-8: effects on antiangiogenesis and tumor growth inhibition

(2008) J Y Yoo et al.   GENE THERAPY

Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis

(2008) Tadashi Moro et al.   LIFE SCIENCES