Inflammatory Response to Different Toxins in Experimental Sepsis Models

TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells

(2018) Christian O. Chavarría-Velázquez et al.   IMMUNOBIOLOGY

Surviving sepsis campaign: research priorities for sepsis and septic shock

(2018) Craig M. Coopersmith et al.   INTENSIVE CARE MEDICINE

Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

(2018) Ping Zhou et al.   NATURE

Model of bacterial toxin-dependent pathogenesis explains infective dose

(2018) Joel Rybicki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome

(2017) Valeria M. Reyes Ruiz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

(2017) Milica Milivojevic et al.   PLoS Pathogens

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations

(2016) Carolin Fleischmann et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

(2016) Andrea J. Wolf et al.   CELL

Structure and function: Lipid A modifications in commensals and pathogens

(2016) Alex Steimle et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CD36 Differently Regulates Macrophage Responses to Smooth and Rough Lipopolysaccharide

(2016) Rafał Biedroń et al.   PLoS One

Next-generation sequencing diagnostics of bacteremia in septic patients

(2016) Silke Grumaz et al.   Genome Medicine

Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

(2016) Laura E Sanman et al.   eLife

Differential immune-stimulatory effects of LTAs from different lactic acid bacteria via MAPK signaling pathway in RAW 264.7 cells

(2015) Ji Hye Jeong et al.   IMMUNOBIOLOGY

Endotoxemia as a Diagnostic Tool for Patients with Suspected Bacteremia Caused by Gram-Negative Organisms: a Meta-Analysis of 4 Decades of Studies

(2015) James C. Hurley et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Vibrio cholerae porin OmpU induces LPS tolerance by attenuating TLR-mediated signaling

(2015) Sanica C. Sakharwade et al.   MOLECULAR IMMUNOLOGY

Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

(2015) R. G. Gaudet et al.   SCIENCE

Cytokine profile in severe gram-positive and gram-negative abdominal sepsis

(2015) Maja Surbatovic et al.   Scientific Reports

Characterization of lipoteichoic acid structures from three probiotic Bacillus strains: involvement of d-alanine in their biological activity

(2014) Romain Villéger et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

(2014) O. Schneewind et al.   JOURNAL OF BACTERIOLOGY

Lipoteichoic Acid Isolated from Lactobacillus plantarum Inhibits Lipopolysaccharide-Induced TNF-  Production in THP-1 Cells and Endotoxin Shock in Mice

(2014) H. G. Kim et al.   JOURNAL OF IMMUNOLOGY

Long Term Outcomes Following Hospital Admission for Sepsis Using Relative Survival Analysis: A Prospective Cohort Study of 1,092 Patients with 5 Year Follow Up

(2014) Joshua S. Davis et al.   PLoS One

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structural Insights into the Dual Strategy of Recognition by Peptidoglycan Recognition Protein, PGRP-S: Structure of the Ternary Complex of PGRP-S with Lipopolysaccharide and Stearic Acid

(2013) Pradeep Sharma et al.   PLoS One

Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria

(2013) Stefan G. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathways Involved in the Synergistic Activation of Macrophages by Lipoteichoic Acid and Hemoglobin

(2012) Kathleen H. Cox et al.   PLoS One

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Similarities and differences of innate immune responses elicited by smooth and rough LPS

(2011) Ivan Zanoni et al.   IMMUNOLOGY LETTERS

Aquaporin 9 phosphorylation mediates membrane localization and neutrophil polarization

(2011) Thommie Karlsson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pathogen associated molecular pattern motifs from Gram-positive and Gram-negative bacteria induce different inflammatory mediator profiles in equine blood

(2011) A.E. DeClue et al.   VETERINARY JOURNAL

Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa

(2011) Thomas W. Cullen et al.   PLoS Pathogens

Claudin-6, 7, or 9 Overexpression in the Human Gastric Adenocarcinoma Cell Line AGS Increases Its Invasiveness, Migration, and Proliferation Rate

(2010) Veronica Elizabeth Zavala-Zendejas et al.   CANCER INVESTIGATION

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

(2010) Todd W. Rice et al.   CRITICAL CARE MEDICINE

Proinflammatory signal transduction pathway induced by Shigella flexneri porins in caco-2 cells

(2009) Grimaldi Elena et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Binding and Cellular Activation Studies Reveal That Toll-like Receptor 2 Can Differentially Recognize Peptidoglycan from Gram-positive and Gram-negative Bacteria

(2009) Jinkeng Asong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

A Changing Gastric Environment Leads to Adaptation of Lipopolysaccharide Variants in Helicobacter pylori Populations during Colonization

(2009) Anna Skoglund et al.   PLoS One