A Hydroquinone-Based Derivative Elicits Apoptosis and Autophagy via Activating a ROS-Dependent Unfolded Protein Response in Human Glioblastoma

Structural insight into the optimization of ethyl 5-hydroxybenzo[g]indol-3-carboxylates and their bioisosteric analogues as 5-LO/m-PGES-1 dual inhibitors able to suppress inflammation

(2018) Ferdinando Bruno et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of benzoquinone and hydroquinone derivatives as potent inhibitors of human 5-lipoxygenase

(2017) Antonella Peduto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Nexus Implicated in Bowel Disease Pathophysiology

(2017) Wai Chong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis

(2017) Zhongling Zhu et al.   JOURNAL OF NEUROCHEMISTRY

The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo

(2016) Anja M. Schaible et al.   BIOCHEMICAL PHARMACOLOGY

Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition

(2016) Antonella Peduto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells

(2016) S. Zappavigna et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes

(2015) Rosanna Filosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma

(2015) Ling Li et al.   Oncotarget

Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing

(2015) Vikas Patil et al.   Oncotarget

Elucidation of the molecular mechanism and the efficacyin vivoof a novel 1,4-benzoquinone that inhibits 5-lipoxygenase

(2014) A M Schaible et al.   BRITISH JOURNAL OF PHARMACOLOGY

Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: Design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase

(2014) Antonella Peduto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin

(2013) Anja M. Schaible et al.   BIOCHEMICAL PHARMACOLOGY

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase

(2013) Rosanna Filosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation

(2013) Carmen Petronzi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

(2011) Antonella Peduto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Cytotoxic Activity of New β-Carboline Derivatives

(2011) A. Peduto et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Structure-based design, synthesis and preliminary anti-inflammatory activity of bolinaquinone analogues

(2010) Carmen Petronzi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

5-Lipoxygenase inhibitors: a review of recent developments and patents

(2010) Carlo Pergola et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors

(2008) Rosanna Filosa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control

(2008) Diego F. Calvisi et al.   INTERNATIONAL JOURNAL OF CANCER