Article
Oncology
Roberto Ronca, Sara Taranto, Michela Corsini, Chiara Tobia, Cosetta Ravelli, Sara Rezzola, Mirella Belleri, Floriana De Cillis, Annamaria Cattaneo, Marco Presta, Arianna Giacomini
Summary: This study demonstrates the anti-angiogenic role of PTX3 produced by multiple myeloma cells, showing that induced expression of PTX3 can impede MM neovascularization, prevent the formation of a proficient BM vascular niche, and ultimately reduce tumor growth and dissemination. PTX3 overexpression leads to a significant reduction in tumor burden in both subcutaneously grafted and systemic MM models, paving the way for potential anti-angiogenic strategies in MM treatment.
Review
Cell Biology
Anita Novais, Eirini Chatzopoulou, Catherine Chaussain, Caroline Gorin
Summary: Bone is a hard tissue that constantly renews itself to adapt to the body's demands. The craniofacial area is prone to trauma and pathologies, often leading to large bone damage. Autologous bone grafting is the gold standard for treating these defects, but has drawbacks such as the need for a second surgical site and limitations in bone quantity.
Review
Medicine, General & Internal
Kaja Michalczyk, Natalia Niklas, Malgorzata Rychlicka, Aneta Cymbaluk-Ploska
Summary: Endometrial cancer is a common gynecological neoplasm in developed countries with high early diagnosis rates and good prognosis, but a high recurrence rate in later stages. Factors secreted by adipose tissue play a significant role in regulating glucose and lipid metabolism and influence the diagnosis and prognosis of endometrial cancer.
Review
Biochemistry & Molecular Biology
Friederike Freiin von Hoevel, Ekaterini Kefalakes, Claudia Grothe
Summary: FGF-2 exists in multiple isoforms of different molecular weights in various animals, playing important roles in cell growth, migration, and maturation, and influencing the functions and disease models of organ systems such as the cardiovascular system, bone formation, and the nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ali Niapour, Naisana Seyedasli
Summary: This study successfully developed PTX-resistant AGS-R cells, exhibiting resistance to multiple drugs and alterations in key signaling pathways related to survival, EMT, and angiogenesis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muthukumar Elangovan, Jun Ka, Boryeong Pak, Woosoung Choi, Se-Ra Oh, Suk-Won Jin, Yung Joon Yoo
Summary: Ubiquitination plays an important regulatory role in angiogenesis, with E3 enzymes being extensively studied. The role of E2 enzymes in angiogenesis is less known. Through analysis of single-cell RNA sequencing data, UBE2V1 was identified as one of the most abundantly expressed E2s in endothelial cells. Inhibition of UBE2V1 affects endothelial cell proliferation, viability, morphogenesis, and migration, and is critical for FGF2-induced angiogenesis.
Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell Biology
Igor Prudovsky
Summary: FGF family growth factors are crucial in tissue and organ repair after trauma, regulating various aspects of cellular behavior to facilitate reparative processes. Specifically, FGFs play a key role in controlling cell proliferation, stemness, de-differentiation, inflammation, angiogenesis, senescence, cell death, and protease production. Additionally, enhancing FGF expression and secretion in damaged tissues can increase the supply of FGF required for tissue repair.
Article
Medicine, Research & Experimental
Shuzhan Shen, Guorong Yan, Yajing Cao, Qingyu Zeng, Jingjun Zhao, Xiuli Wang, Peiru Wang
Summary: This study demonstrates that n-3 polyunsaturated fatty acids have therapeutic effects on rosacea by regulating various biological processes and signaling pathways, leading to improvements in skin erythema and inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Jing Chen, Zhenghuan Rao, Qinqin Li, Tao Jiang, Yuan Chen, Xia Gu, Mengyue Miao, Daifeng Hu, Hui Zhou, Alexander Tobias Teichmann, Youzhe Yang
Summary: The study demonstrates the beneficial effects of FK-morph on a surgically induced endometriosis rat model. FK-morph effectively reduces the volumes and adhesion scores of implants, downregulates inflammatory cytokines and chemokines levels, mediates cell apoptosis of endometriosis foci, and attenuates angiogenesis by decreasing the expression of VEGF. The underlying mechanism involves blocking the activation of the PI3K/Akt and NF-xB signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Gizem Erensoy, Kai Ding, Chang-Guo Zhan, Gamze Ciftci, Kemal Yelekci, Merve Duracik, Ozlem Bingol Ozakpinar, Esra Aydemir, Zubeyde Nur Yilmaz, Fikrettin Sahin, Necla Kulabas, Esra Tatar, Ilkay Kucukguzel
Summary: mPGES-1 is an important enzyme involved in PGE2 synthesis and its inhibition holds promise for the discovery of anti-inflammatory and anti-cancer drugs. The design of mPGES-1 inhibitors can provide better control of PGE2-associated diseases compared to traditional drugs with serious side effects. However, no mPGES-1 inhibitors have reached the clinical market yet, highlighting the need for the development of novel inhibitors with suitable drug-like properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Ophthalmology
Wenyi Wu, Xiabo Xia, Luosheng Tang, Jing Luo, Siqi Xiong, Gaoen Ma, Hetian Lei
Summary: This article summarizes the molecular mechanisms of PI3K inhibitors in preventing vessel permeability and neovascularization, and discusses the roles of different PI3K isoforms in angiogenesis.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jun Liu, Patrick Budylowski, Reuben Samson, Bryan D. Griffin, Giorgi Babuadze, Bhavisha Rathod, Karen Colwill, Jumai A. Abioye, Jordan A. Schwartz, Ryan Law, Lily Yip, Sang Kyun Ahn, Serena Chau, Maedeh Naghibosadat, Yuko Arita, Queenie Hu, Feng Yun Yue, Arinjay Banerjee, W. Rod Hardy, Karen Mossman, Samira Mubareka, Robert A. Kozak, Michael S. Pollanen, Natalia Martin Orozco, Anne-Claude Gingras, Eric G. Marcusson, Mario A. Ostrowski
Summary: This article reports the preclinical development of a lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccine, PTX-COVID19-B. It was chosen among three candidates after showing the strongest immune response in mouse vaccination. Further tests in mice and hamsters demonstrated that PTX-COVID19-B induced robust immune responses and provided complete protection against SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Issei Shinohara, Masanori Tsubosaka, Masakazu Toya, Max L. Lee, Junichi Kushioka, Masatoshi Murayama, Qi Gao, Xueping Li, Ning Zhang, Simon Kwoon-Ho Chow, Tomoyuki Matsumoto, Ryosuke Kuroda, Stuart B. Goodman
Summary: Local cell therapy using mesenchymal stem cells (MSCs) has gained attention for treating joint diseases and fractures. This study investigated the utility of C-C motif chemokine ligand 2 (CCL2) as a therapeutic target for this therapy. The results showed that overexpression of CCL2 promoted macrophage chemotaxis and osteogenesis, as well as angiogenesis, through crosstalk between MSCs and macrophages. These findings suggest that CCL2 may be a useful target for local cell therapy in areas of bone loss.
Article
Biochemistry & Molecular Biology
Oladipupo Moyinoluwa David, Kim Leigh Lategan, Maria Fidalgo de Cortalezzi, Edmund John Pool
Summary: This study investigated the effects of various media on the properties of TiO2NPs and the effects of TiO2NP exposure on human cells. The results showed that TiO2NPs increased in size over time in different media, but the zeta potential remained stable. In addition, TiO2NPs induced cell stress biomarkers but had no effect on inflammatory biomarkers. Moreover, TiO(2)NPs displayed some anti-angiogenic properties at the no-observed-adverse-effect level and require further investigation.
Article
Oncology
Paola Chiodelli, Daniela Coltrini, Marta Turati, Marianna Cerasuolo, Federica Maccarinelli, Sara Rezzola, Elisabetta Grillo, Arianna Giacomini, Sara Taranto, Silvia Mussi, Alessia Ligresti, Marco Presta, Roberto Ronca
Summary: The study validates the therapeutic efficacy of the FDA-approved FGFR inhibitor pemigatinib in treating PCa and CRPC, and reveals its synergistic effect with enzalutamide in inhibiting tumor growth, providing valuable data support for the clinical application of this treatment approach.
Article
Immunology
Tiziana Annese, Roberto Tamma, Mariella Bozza, Alfredo Zito, Domenico Ribatti
Summary: c-Kit receptor is expressed and involved in various biological processes in mucosal mast cells, such as cell survival, proliferation, hematopoiesis, and melanogenesis. This study found that in melanoma, mast cells express and release SCF and c-Kit receptors, potentially regulating tumor progression through an autocrine/paracrine loop.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Giuseppe Ingravallo, Roberto Tamma, Giuseppina Opinto, Tiziana Annese, Francesco Gaudio, Giorgina Specchia, Tommasina Perrone, Pellegrino Musto, Gerardo Cazzato, Emilio Bellitti, Saverio Capodiferro, Eugenio Maiorano, Domenico Ribatti
Summary: Lymphomas are tumors that grow in an inflammatory microenvironment, and the cells in this environment are crucial for the growth and survival of neoplastic cells. These cells are recruited by cytokines/chemokines. Lymphomas include a diverse group of tumors that invade various lymphoid structures and may originate from different types of lymphocytes at different stages of differentiation.
Article
Biochemistry & Molecular Biology
Alessandra Loda, Marta Turati, Francesco Semeraro, Sara Rezzola, Roberto Ronca
Summary: Ocular tumors are rare neoplasms that develop in the eye. Current treatments can control the local tumor, but some patients develop metastatic disease. New targets and players are needed to prevent and control tumor growth and metastasis. The fibroblast growth factor/receptor system plays a relevant role in ocular tumors and may have prognostic and therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Gerardo Cazzato, Katia Mangialardi, Giovanni Falcicchio, Anna Colagrande, Giuseppe Ingravallo, Francesca Arezzo, Giovanna Giliberti, Irma Trilli, Vera Loizzi, Teresa Lettini, Sara Scarcella, Tiziana Annese, Paola Parente, Carmelo Lupo, Nadia Casatta, Eugenio Maiorano, Gennaro Cormio, Leonardo Resta, Domenico Ribatti
Summary: The use of PRAME as a tumor marker holds potential value in the diagnosis and immunotherapeutic approach to cancer. However, its specificity is lower and it may also be expressed in atypical lesions.
Review
Oncology
Davide Capoferri, Serena Filiberti, Jessica Faletti, Camilla Tavani, Roberto Ronca
Summary: Understanding the characteristics of cancer cells is crucial for studying tumor biology. Both traditional cell lines and modern genome editing techniques have played important roles in cancer research.
Article
Cell Biology
Roberto Tamma, Giuseppe Ingravallo, Tiziana Annese, Antonio d'Amati, Loredana Lorusso, Domenico Ribatti
Summary: In this study, we analyzed biopsy specimens from adult patients with IDH1 wild type GBM and found that there was a significant increase in the number of total and M2 type macrophages, CD4(+)- and CD8(+)-lymphocytes, and CD34(+) microvessels in the tumor area compared to the healthy surrounding tissue. We also confirmed previous findings that there were higher numbers of p53 and BCL6(+) cells in the tumor area, with a positive correlation between BCL6 and CD34(+) microvessels. These results suggest that microenvironment components play an important role in GBM progression and could potentially be targeted for new therapies.
Review
Biochemistry & Molecular Biology
Luca Mignani, Jessica Guerra, Marzia Corli, Davide Capoferri, Marco Presta
Summary: Sphingolipidoses are inborn errors of metabolism caused by pathogenic mutations in genes involved in sphingolipid catabolism, leading to lysosomal accumulation of defective proteins. Zebrafish is a valuable model system for studying the pathogenesis and therapeutic approaches of sphingolipidoses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Lucarelli, Giuseppe Stefano Netti, Monica Rutigliano, Francesco Lasorsa, Davide Loizzo, Martina Milella, Annalisa Schirinzi, Antonietta Fontana, Francesca Di Serio, Roberto Tamma, Domenico Ribatti, Michele Battaglia, Elena Ranieri, Pasquale Ditonno
Summary: MUC1 is overexpressed in clear cell renal cell carcinoma (ccRCC) and is associated with aggressive cancer phenotype and chemoresistance. This study found that MUC1 can regulate the immunoflammatory response in the tumor microenvironment by activating the classical pathway of the complement system and is associated with the expression of pentraxin-3 (PTX3). The results suggest that MUC1 expression can modulate the immune infiltration in the ccRCC microenvironment and promote the formation of an immune-silent microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Gerardo Cazzato, Eliano Cascardi, Anna Colagrande, Teresa Lettini, Alessandra Filosa, Francesca Arezzo, Carmelo Lupo, Nadia Casatta, Vera Loizzi, Cristina Pellegrini, Maria Concetta Fargnoli, Eugenio Maiorano, Gerolamo Cicco, Roberto Tamma, Giuseppe Ingravallo
Summary: T cell immunoglobulin and mucin domain 3 (TIM-3) is an inhibitory immunocheckpoint that has been investigated for its role in the tumour microenvironment of melanoma. This review provides the most up-to-date knowledge about TIM-3 in melanoma and discusses future prospects and potential applications.
Article
Oncology
Domenico Ribatti, Roberto Tamma, Tiziana Annese, Antonio d'Amati, Giuseppe Ingravallo, Giorgina Specchia
Summary: Angiogenesis is the main mechanism for new blood vessel formation in tumors. Recent studies have shown that non-angiogenic pathways also play an important role in tumor resistance to anti-angiogenic therapies. This review discusses the current knowledge on vessel formation in lymphomas and its implications for prognosis and treatment.
Article
Oncology
Roberto Tamma, Giuseppe Ingravallo, Francesco Gaudio, Antonio d'Amati, Pierluigi Masciopinto, Emilio Bellitti, Loredana Lorusso, Tiziana Annese, Vincenzo Benagiano, Pellegrino Musto, Giorgina Specchia, Domenico Ribatti
Summary: Although classical Hodgkin lymphoma (CHL) is generally curable, a significant percentage of patients experience relapse and succumb to the disease. The cellular microenvironment in CHL consists of a small number of H/RS tumor cells surrounded by various inflammatory cells. Understanding the interaction between H/RS cells and immune cells in the microenvironment could lead to new targeted immunotherapies. This study analyzed the microenvironment composition in CHL patients with responsive disease (RESP) and relapsed/refractory disease (REL). The results revealed differences in the abundance of specific immune cells and microvessels between RESP and REL patients.
Article
Biochemistry & Molecular Biology
Paloma Begines, Alessandro Bonardi, Alessio Nocentini, Paola Gratteri, Simone Giovannuzzi, Roberto Ronca, Camilla Tavani, Maria Luisa Massardi, Oscar Lopez, Claudiu T. Supuran
Summary: This study successfully synthesized a variety of compounds that conjugate biotin with sulfonamide motifs and tested their efficacy as carbonic anhydrase inhibitors in vitro. Most of the synthesized compounds showed interesting inhibition profiles in the nanomolar range, and some compounds exhibited good selectivity towards tumor-associated enzymes. One compound demonstrated anti-proliferative activity in multiple tumor cell lines.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Marta Turati, Gianluca Mattei, Alessia Boaretto, Alberto Magi, Maura Calvani, Roberto Ronca
Summary: The lymphatic vascular system plays a crucial role in cancer progression by activating lymphatic endothelial cells and facilitating the formation of new lymphatic vessels. This study revealed that cancer-derived and microenvironmental mediators activate specific molecular pathways in lymphatic endothelial cells, leading to endothelial activation, morphogenesis, and cytokine-mediated signaling. The findings provide new insights into the lymphangiogenesis process and its relevance in different types of tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
