Review
Cell Biology
Mariya Farooq, Abdul Waheed Khan, Moon Suk Kim, Sangdun Choi
Summary: Fibroblast growth factors (FGFs) are a large family of secretory molecules that play crucial roles in various cellular functions through different signaling pathways. They are involved in cell proliferation, survival, metabolism, morphogenesis, differentiation, tissue repair and regeneration.
Review
Dermatology
Daniel Bormann, Alfred Gugerell, Hendrik Jan Ankersmit, Michael Mildner
Summary: Cell secretomes play an important role in wound healing by promoting regeneration. This study reviews the mechanisms of action of cell secretomes in wound healing, important preconditioning strategies to enhance therapeutic efficacy, and clinical trials on secretome-based wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Hannah E. Walters, Konstantin E. Troyanovskiy, Alwin M. Graf, Maximina H. Yun
Summary: Salamanders are able to regenerate their limbs by modulating cellular plasticity and inducing cellular senescence, which can enhance muscle dedifferentiation and regeneration. Senescent cells promote myotube cell cycle re-entry and reversal of muscle identity through secreted factors, with the FGF-ERK signalling axis playing a critical role. This study highlights the beneficial role of cellular senescence in complex structure regeneration.
Article
Biotechnology & Applied Microbiology
Wenjuan Wang, Min Zhang, Xuejing Ren, Yanqi Song, Yue Xu, Kaiting Zhuang, Tuo Xiao, Xinru Guo, Siyang Wang, Quan Hong, Zhe Feng, Xiangmei Chen, Guangyan Cai
Summary: This study investigated the therapeutic mechanisms of mesenchymal stem cells (MSCs) in acute kidney injury (AKI) using unbiased single-cell RNA sequencing. The research revealed the transcriptomic diversity of tubular epithelial cells (TECs) and immune cells, and identified a repair trajectory involving renal stem/progenitor cell differentiation. The study also found that MSC-derived miR-26a-5p played a role in mediating the therapeutic effects of MSCs by inhibiting the expression of pro-fibrotic TECs and the recruitment of immune cell subpopulations.
Article
Engineering, Biomedical
Ping Wu, Zan Tong, Lihua Luo, Yanan Zhao, Feixiang Chen, Yinping Li, Celine Huselstein, Qifa Ye, Qingsong Ye, Yun Chen
Summary: The combination of VEGF and Schwann cells in peripheral nerve repair shows promising results in promoting nerve regeneration. The HSPS conduits loaded with VEGF-A overexpressing Schwann cells demonstrate high durability and efficiency in repairing nerve tissue, making them a potential new avenue for nerve tissue engineering.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiaotao Xing, Haisen Huang, Xin Gao, Jian Yang, Qi Tang, Xun Xu, Yutao Wu, Maojiao Li, Cheng Liang, Lin Tan, Li Liao, Weidong Tian
Summary: Elimination of senescent bone marrow mesenchymal stem cells (BMSCs) can promote bone regeneration in the elderly, providing a novel approach for treating bone defects in aged individuals.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Sandra Benitez, Alex Cordero, Patricia G. Santamaria, Jaime Redondo-Pedraza, Ana S. Rocha, Alejandro Collado-Sole, Maria Jimenez, Adrian Sanz-Moreno, Guillermo Yoldi, Juliana C. Santos, Ilaria De Benedictis, Clara Gomez-Aleza, Sabela Da Silva-Alvarez, Kevin Troule, Gonzalo Gomez-Lopez, Noelia Alcazar, Ignacio Palmero, Manuel Collado, Manuel Serrano, Eva Gonzalez-Suarez
Summary: Rank signaling enhances stemness and delays tumor initiation by inducing senescence in mammary epithelial cells, yet eventually promotes tumor progression and metastasis.
DEVELOPMENTAL CELL
(2021)
Review
Cell & Tissue Engineering
Bo Li, Yunmei Yang, Lan Wang, Guanghua Liu
Summary: Intervertebral disc (IVD) as part of the motor system is a complicated tissue that may lead to low back pain (LBP) due to degeneration, caused by factors such as cell senescence, hydration lost, and inflammation. Stem cells found in various organs have attracted researchers and clinicians for their potential in treating tissue injury and degeneration, while the effects of exercise on IVD degeneration and the relationship between IVD degeneration and musculoskeletal disorders like sarcopenia are also under discussion.
STEM CELLS INTERNATIONAL
(2021)
Article
Food Science & Technology
Lina Che, Caixia Zhu, Lei Huang, Hui Xu, Xinmiao Ma, Xuegang Luo, Hongpeng He, Tongcun Zhang, Nan Wang
Summary: We evaluated the changes in autophagy in porcine MSCs (pMSCs) during long-term culture in vitro and identified ginsenoside Rg2 as a potential stimulator for pMSC proliferation. Aged pMSCs exhibited typical senescent characteristics, while their autophagic flux was impaired. Rg2 promoted pMSC proliferation, inhibited senescence and oxidative stress, and increased autophagic activity through the AMPK signaling pathway. Rg2 also maintained the stemness of pMSCs during long-term culture.
Article
Cell Biology
Lucia Antelo-Iglesias, Pilar Picallos-Rabina, Valentin Estevez-Souto, Sabela Da Silva-Alvarez, Manuel Collado
Summary: The capacity to regenerate damaged or lost tissue varies widely along the animal kingdom, with senescent cells playing a role in reduced tissue function with aging. However, senescence has been shown to have positive effects in tissue development during embryogenesis and tissue repair. Research on different organismal models is shedding light on the novel functions of cellular senescence.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Engineering, Biomedical
Ni Ni, Min Ge, Rui Huang, Dandan Zhang, Han Lin, Yahan Ju, Zhimin Tang, Huiqin Gao, Huifang Zhou, Yu Chen, Ping Gu
Summary: Bone healing is a complex process involving the recruitment of cells, revascularization, and osteogenic differentiation. Insufficient osteoblast cells, poor blood supply, and limited bone induction at the site of critical-sized bone defect hinder bone repair. To address this issue, SiO2-silicene@AIPH nanoparticles were designed to efficiently promote bone repair through controlled near-infrared irradiation. These nanoparticles stimulated cellular activities, including proliferation and angiogenesis, and promoted osteogenic differentiation. In a rat cranial defect model, the engineered nanoparticles demonstrated remarkable bone repair efficiency. This bionic-oriented strategy offers a new perspective for the application of cell-instructive biomaterials in bone tissue engineering.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cell Biology
Luiza Steffens Reinhardt, Kira Groen, Xiajie Zhang, Brianna C. Morten, Anna Wawruszak, Kelly A. Avery-Kiejda
Summary: In breast cancer, dysregulated TP53 expression signatures are more accurate predictors of chemotherapy response and survival outcomes than TP53 mutations. High levels of & UDelta;40p53 are associated with worse disease-free survival and disruption of p53-induced DNA damage response. We found that genes related to cell differentiation were downregulated, while those associated with stem cell regulation were upregulated in invasive ductal carcinomas expressing high levels of & UDelta;40p53. Furthermore, high levels of & UDelta;40p53 induce tumor growth, promote chemoresistance, and enhance the stemness phenotype in breast cancer. Targeting tumors with a high & UDelta;40p53:p53 ratio could improve the efficacy of standard-of-care therapies.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Inorganic & Nuclear
Wajid Ali, Fatemeh Jamshidi-Adegani, Zahra Mirsanei, Juhaina Al-Kindi, Saeid Vakilian, Mohammed Al-Broumi, Sulaiman Al-Hashmi, Jeremy M. Rawson, Ahmed Al-Harrasi, Muhammad Usman Anwar
Summary: In this study, a series of tetranuclear Ln(iii) complexes were prepared using a tridentate ligand LH3. The potential of these complexes for wound healing applications was evaluated. Among the tested complexes, complex 2(Eu) displayed the most potent anti-inflammatory effect on macrophage cells, while simultaneously promoting fibroblast viability and migration, making it highly promising for wound healing applications.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Bence Daniel, Julia A. Belk, Stefanie L. Meier, Andy Y. Chen, Katalin Sandor, Zsolt Czimmerer, Zsofia Varga, Krisztian Bene, Frank A. Buquicchio, Yanyan Qi, Hugo Kitano, Joshua R. Wheeler, Deshka S. Foster, Michael Januszyk, Michael T. Longaker, Howard Y. Chang, Ansuman T. Satpathy
Summary: Cell cycle regulates macrophage plasticity and gene expression, influencing their immune response and tissue remodeling programs. Macrophages exhibit reduced responsiveness to interferon gamma during S-G2/M phases and IL-4 induces S-G2/M-biased gene expression through cell cycle-biased enhancers. Macrophage response in diseases, such as airway inflammation and pulmonary fibrosis, is modulated by cell cycle, leading to phase-dependent inflammatory and regenerative programs.
Article
Cell Biology
Guilian Liao, Yan Liao, Duanduan Li, Zeqin Fu, Shiduo Wu, Danling Cheng, Qiuxing Ouyang, Zan Tang, Guifang Zeng, Xiao Liang, Shaokun Xu, Junyuan Hu, Muyun Liu
Summary: Culture supplement of human platelet lysate (hPL) enhances the growth and differentiation potential of umbilical cord-derived mesenchymal stromal cells (UC-MSCs), leading to improved therapeutic efficacy for newborn bronchopulmonary dysplasia (BPD) in preclinical models.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)