mTOR Complex 2 Targets Akt for Proteasomal Degradation via Phosphorylation at the Hydrophobic Motif

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

(2010) Adam S. Lazorchak et al.   MOLECULAR CELL

PI3K Regulatory Subunits Lose Control in Cancer

(2009) Inma Martin-Berenjeno et al.   CANCER CELL

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

(2009) Srivatsan Padmanabhan et al.   CELL

mTOR and cancer: many loops in one pathway

(2009) Alejo Efeyan et al.   CURRENT OPINION IN CELL BIOLOGY

Diversity of Polyubiquitin Chains

(2009) Anirban Adhikari et al.   DEVELOPMENTAL CELL

The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

(2009) Futoshi Suizu et al.   DEVELOPMENTAL CELL

Blocking Akt-ivity

(2009) D. F. Restuccia et al.   SCIENCE

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Akt and PTEN: β-cell mass and pancreas plasticity

(2009) Lynda Elghazi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Negative Regulation of AKT Activation by BRCA1

(2008) T. Xiang et al.   CANCER RESEARCH

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE