Article
Immunology
Shi-Lin Qiu, Qi-Xiang Sun, Jian-Peng Zhou, Hai-Juan Tang, Yan-Qiong Chen, Fu-Shou Chen, Tao Feng, Zai-Qing He, Hua-Jiao Qin, Min-Chao Duan
Summary: The research reveals that IL-27 plays a negative regulatory role in chronic inflammation induced by smoking, preventing CD8(+)T cells from producing excessive inflammatory responses. This study provides a new therapeutic strategy for smoking-related COPD/emphysema by targeting the IL-27 pathway.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Liu
Summary: Cigarette smoke is a main risk factor for emphysema, and a recent study found that circular RNA can regulate cigarette smoke-induced autophagy and apoptosis in alveolar epithelial cells by inhibiting miRNA. This discovery provides new insights and information for the diagnosis and treatment of emphysema.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Respiratory System
David A. Skerrett-Byrne, Elizabeth G. Bromfield, Heather C. Murray, M. Fairuz B. Jamaluddin, Andrew G. Jarnicki, Michael Fricker, Ama T. Essilfie, Bernadette Jones, Tatt J. Haw, Daniel Hampsey, Amanda L. Anderson, Brett Nixon, Rodney J. Scott, Peter A. B. Wark, Matthew D. Dun, Philip M. Hansbro
Summary: The study utilized proteomics to uncover major protein changes associated with the pathogenesis and disease progression of COPD, including alterations in RNA biosynthesis, inflammatory responses, mitochondrial function, and oxidative stress. These changes provide insight for developing new effective treatment strategies.
Article
Medicine, General & Internal
Xiao-Yue Chen, Yi-Ying Chen, Willie Lin, Chien-Han Chen, Yu-Chieh Wen, Ta-Chih Hsiao, Hsiu-Chu Chou, Kian Fan Chung, Hsiao-Chi Chuang
Summary: The study demonstrates that human umbilical cord-derived mesenchymal stem cells have potential in reducing inflammation and emphysema severity in cigarette smoke-induced emphysematous mice. The effects include decreasing inflammatory cells, regulating cytokine levels, and improving lung fibroblast cell viability.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Medicinal
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Won Ko, Tae-Won Kim
Summary: This study aimed to explore the protective mechanisms of green tea extract (GTE) on cigarette smoke condensate (CSC)-induced emphysema by reducing macrophage-induced protease expression. Results showed that GTE significantly reduced macrophage counts and emphysematous lesions in CSC-exposed mice. Furthermore, GTE suppressed CSC-induced ERK/AP-1 phosphorylation and MMP-9 expression. These findings suggest that GTE can be used as a supplementary agent for preventing emphysema progression in COPD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Oncology
Byung-Seok Kim, Da-Sol Kuen, Choong-Hyun Koh, Hyung-Don Kim, Seon Hee Chang, Sehui Kim, Yoon Kyung Jeon, Young-Jun Park, Garam Choi, Jiyeon Kim, Keon Wook Kang, Hye Young Kim, Suk-Jo Kang, Shin Hwang, Eui-Cheol Shin, Chang-Yuil Kang, Chen Dong, Yeonseok Chung
Summary: IL-17-producing cells promote terminal exhaustion of CD8(+) T cells and tumor progression in vivo, which can be reversed by blockade of IL-17 or ROR gamma t pathway. Human TCGA analyses reveal a strong positive correlation between type 17 and CD8(+) T cell exhaustion signature gene sets in multiple cancers, suggesting type 17 immunity as a promising target for cancer immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Paul Bigot, Simon Chesseron, Ahlame Saidi, Damien Sizaret, Christelle Parent, Agnes Petit-Courty, Yves Courty, Fabien Lecaille, Gilles Lalmanach
Summary: Chronic obstructive pulmonary disease (COPD) is an irreversible disease mainly caused by smoking. The protein occludin, involved in the cohesion of epithelial tight junctions, is found to be decreased in lung biopsies of smokers and correlates with smoking history, COPD grades, and cathepsin S (CatS) activity. Cigarette smoke-elicited CatS induces an alteration of epithelial integrity via the proteolytic injury of occludin, highlighting the emerging role of CatS in smoking-related lung diseases and the relevance of targeting CatS in the treatment of emphysema and COPD.
Article
Plant Sciences
Qiuping Li, Jing Sun, Yuxue Cao, Baojun Liu, Zhengxiao Zhao, Lingli Hu, Hu Zhang, Qing Kong, Jinfeng Wu, Jingcheng Dong
Summary: This study aimed to investigate the effects of ICT on CD8+ T cell chemotaxis and the CXCL10/CXCR3 axis in an in vitro model of COPD. The results showed that ICT significantly suppressed the expression and secretion of key chemokines in macrophages, indirectly inhibiting CD8+ T cell chemotaxis. Additionally, ICT had no significant effect on CD8+ T cell proliferation or apoptosis, and the mechanism of action may involve downregulation of the TGF-beta-Smad2 signaling pathway.
Article
Toxicology
Ee Tsin Wong, Justyna Szostak, Bjoern Titz, Tom Lee, Sin Kei Wong, Oksana Lavrynenko, Celine Merg, Maica Corciulo, Jovan Simicevic, Mehdi Auberson, Dariusz Peric, Remi Dulize, David Bornand, Guo Jie Loh, Kyeonghee Monica Lee, Jingjie Zhang, John H. Miller, Walter K. Schlage, Emmanuel Guedj, Thomas Schneider, Blaine Phillips, Patrice Leroy, Mohamed Amin Choukrallah, Nicolas Sierro, Ansgar Buettner, Yang Xiang, Arkadiusz Kuczaj, Nikolai Ivanov, Karsta Luettich, Patrick Vanscheeuwijck, Manuel C. Peitsch, Julia Hoeng
Summary: This study investigated the effects of electronic cigarette aerosols compared to cigarette smoke on the respiratory system of mice. The results showed that e-vapor aerosols induced substantially lower biological and pathological changes in the respiratory tract associated with chronic inflammation and emphysema, compared to cigarette smoke.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Physiology
Patrick S. Hume, Jazalle McClendon, Katrina W. Kopf, Julie W. Harral, Joanna M. Poczobutt, Alexandra L. McCubbrey, Bradford J. Smith, Peter M. Henson, Susan M. Majka, Irina Petrache, William J. Janssen
Summary: This study examined the role of leukocyte HIF-1α in the development of cigarette smoke-induced lung disease using mice with conditional deletion or overexpression of HIF-1α. The results showed that overexpression of leukocyte HIF-1α did not affect the development of cigarette smoke-induced lung disease, suggesting that this signaling pathway is not involved in the development of murine lung disease.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Aleksandar Dobric, Simone N. De Luca, Huei Jiunn Seow, Hao Wang, Kurt Brassington, Stanley M. H. Chan, Kevin Mou, Jonathan Erlich, Stella Liong, Stavros Selemidis, Sarah J. Spencer, Steven Bozinovski, Ross Vlahos
Summary: The study found that chronic cigarette smoke exposure can cause neurocognitive dysfunction, including impaired working memory, accompanied by neuroinflammation and neuropathological changes in the brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Respiratory System
Wenxin Wu, Lili Tian, Wei Zhang, J. Leland Booth, Erola Ainsua-Enrich, Susan Kovats, Brent R. Brown, Jordan P. Metcalf
Summary: The study revealed that long-term cigarette smoke exposure can cause a biphasic T cell and IFN-gamma response to influenza infection in the lung, leading to changes in cell numbers and IFN-gamma production at different stages.
RESPIRATORY RESEARCH
(2021)
Article
Immunology
Simone N. De Luca, Stanley M. H. Chan, Aleksandar Dobric, Hao Wang, Huei Jiunn Seow, Kurt Brassington, Kevin Mou, Rana Alateeq, Alina Akhtar, Steven Bozinovski, Ross Vlahos
Summary: Chronic obstructive pulmonary disease (COPD) is a respiratory condition caused by cigarette smoking. People with COPD often experience neurocognitive disorders such as cognitive dysfunction, anxiety, and depression. The role of inflammation and oxidative stress in the onset of these disorders is still unclear.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.