Looking to the future of zebrafish as a model to understand the genetic basis of eye disease

Genetics of anophthalmia and microphthalmia. Part 1: Non-syndromic anophthalmia/microphthalmia

(2019) J. Plaisancié et al.   HUMAN GENETICS

PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components

(2019) Zhipeng Ma et al.   NATURE

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

(2019) Rodrigo M Young et al.   eLife

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

(2019) Holly Hardy et al.   eLife

FOXE3 mutations: genotype-phenotype correlations

(2018) J. Plaisancié et al.   CLINICAL GENETICS

New Developments in CRISPR/Cas-based Functional Genomics and their Implications for Research Using Zebrafish

(2018) Sergey V. Prykhozhij et al.   CURRENT GENE THERAPY

A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish

(2018) Roland S. Wu et al.   DEVELOPMENTAL CELL

Cell Behaviors during Closure of the Choroid Fissure in the Developing Eye

(2018) Gaia Gestri et al.   Frontiers in Cellular Neuroscience

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

(2018) Clare Turnbull et al.   BMJ-British Medical Journal

TGFβ-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism

(2018) Max D. Knickmeyer et al.   Open Biology

Role of duplicate genes in determining the tissue-selectivity of hereditary diseases

(2018) Ruth Barshir et al.   PLoS Genetics

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

(2018) Clare Turnbull et al.   BMJ-British Medical Journal

The Birth of the Eye Vesicle: When Fate Decision Equals Morphogenesis

(2018) Florence A. Giger et al.   Frontiers in Neuroscience

Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis

(2018) S. Okuda et al.   Science Advances

Genetic approaches to retinal research in zebrafish

(2017) Stephanie Niklaus et al.   JOURNAL OF NEUROGENETICS

Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity

(2017) Danish Saleheen et al.   NATURE

Genes and pathways in optic fissure closure

(2017) Aara Patel et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Guidelines for morpholino use in zebrafish

(2017) Didier Y. R. Stainier et al.   PLoS Genetics

Genetic compensation: A phenomenon in search of mechanisms

(2017) Mohamed A. El-Brolosy et al.   PLoS Genetics

Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

(2017) Jaydeep Sidhaye et al.   eLife

Coordinated Morphogenetic Mechanisms Shape the Vertebrate Eye

(2017) Juan-Ramon Martinez-Morales et al.   Frontiers in Neuroscience

Retina regeneration in zebrafish

(2016) Jin Wan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis

(2016) Chase D. Bryan et al.   DEVELOPMENTAL BIOLOGY

The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye

(2016) Andrea James et al.   DEVELOPMENTAL BIOLOGY

The zebrafish eye—a paradigm for investigating human ocular genetics

(2016) R Richardson et al.   EYE

Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development

(2016) Jaroslav Icha et al.   Jove-Journal of Visualized Experiments

Conserved genetic pathways associated with microphthalmia, anophthalmia, and coloboma

(2015) Linda M. Reis et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Watching eyes take shape

(2015) Naiara Bazin-Lopez et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse

(2015) A. C. Carpenter et al.   DEVELOPMENT

Yap and Taz regulate retinal pigment epithelial cell fate

(2015) J. B. Miesfeld et al.   DEVELOPMENT

Morpholinos: Antisense and Sensibility

(2015) Martin Blum et al.   DEVELOPMENTAL CELL

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Identification of a large set of rare complete human knockouts

(2015) Patrick Sulem et al.   NATURE GENETICS

Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

(2015) Stephan Heermann et al.   eLife

Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects

(2014) Kathleen A. Williamson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The genetic architecture of microphthalmia, anophthalmia and coloboma

(2014) Kathleen A. Williamson et al.   European Journal of Medical Genetics

Zebrafish—on the move towards ophthalmological research

(2014) J Chhetri et al.   EYE

Mutation of SALL2 causes recessive ocular coloboma in humans and mice

(2014) D. Kelberman et al.   HUMAN MOLECULAR GENETICS

Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis

(2013) F. Cavodeassi et al.   DEVELOPMENT

Precocious Acquisition of Neuroepithelial Character in the Eye Field Underlies the Onset of Eye Morphogenesis

(2013) Kenzo Ivanovitch et al.   DEVELOPMENTAL CELL

Retinal pigment epithelium development, plasticity, and tissue homeostasis

(2013) Sabine Fuhrmann et al.   EXPERIMENTAL EYE RESEARCH

An eye on eye development

(2013) Rebecca Sinn et al.   MECHANISMS OF DEVELOPMENT

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

In vitro organogenesis in three dimensions: self-organising stem cells

(2012) Y. Sasai et al.   DEVELOPMENT

BMP Signaling Protects Telencephalic Fate by Repressing Eye Identity and Its Cxcr4-Dependent Morphogenesis

(2012) Holger Bielen et al.   DEVELOPMENTAL CELL

The logic of gene regulatory networks in early vertebrate forebrain patterning

(2012) Leonardo Beccari et al.   MECHANISMS OF DEVELOPMENT

Eye Development and Retinogenesis

(2012) W. Heavner et al.   Cold Spring Harbor Perspectives in Biology

Relaxation-expansion model for self-driven retinal morphogenesis

(2011) Mototsugu Eiraku et al.   BIOESSAYS

A complex choreography of cell movements shapes the vertebrate eye

(2011) K. M. Kwan et al.   DEVELOPMENT

The visual system of zebrafish and its use to model human ocular Diseases

(2011) Gaia Gestri et al.   Developmental Neurobiology

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Nlcam modulates midline convergence during anterior neural plate morphogenesis

(2009) Katherine E. Brown et al.   DEVELOPMENTAL BIOLOGY

Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators

(2009) Gaia Gestri et al.   HUMAN GENETICS

Dynamic Coupling of Pattern Formation and Morphogenesis in the Developing Vertebrate Retina

(2009) Alexander Picker et al.   PLOS BIOLOGY

Controlling morpholino experiments: don't stop making antisense

(2008) J. S. Eisen et al.   DEVELOPMENT