Evolutionary Dissection of the Dot/Icm System Based on Comparative Genomics of 58 Legionella Species

More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

(2019) Laura Gomez-Valero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

(2018) Amit Meir et al.   Nature Communications

A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel

(2018) David Chetrit et al.   Nature Microbiology

DAMBE6: New Tools for Microbial Genomics, Phylogenetics, and Molecular Evolution

(2017) Xuhua Xia   JOURNAL OF HEREDITY

Improved Algorithmic Complexity for the 3SEQ Recombination Detection Algorithm

(2017) Ha Minh Lam et al.   MOLECULAR BIOLOGY AND EVOLUTION

Legionella and Coxiella effectors: strength in diversity and activity

(2017) Jiazhang Qiu et al.   NATURE REVIEWS MICROBIOLOGY

Polar delivery ofLegionellatype IV secretion system substrates is essential for virulence

(2017) Kwangcheol C. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the roles of the IcmS–IcmW complex in the type IVb secretion system ofLegionella pneumophila

(2017) Jianpo Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Many Hosts, One Accidental Pathogen: The Diverse Protozoan Hosts of Legionella

(2017) David K. Boamah et al.   Frontiers in Cellular and Infection Microbiology

Architecture of the type IV coupling protein complex of Legionella pneumophila

(2017) Mi-Jeong Kwak et al.   Nature Microbiology

Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world

(2016) Alexander W Ensminger   CURRENT OPINION IN MICROBIOLOGY

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

(2016) David Burstein et al.   NATURE GENETICS

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

(2016) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

IBS: an illustrator for the presentation and visualization of biological sequences: Fig. 1.

(2015) Wenzhong Liu et al.   BIOINFORMATICS

Formation of a pathogen vacuole according toLegionella pneumophila: how to kill one bird with many stones

(2015) Ivo Finsel et al.   CELLULAR MICROBIOLOGY

Less Is More: An Adaptive Branch-Site Random Effects Model for Efficient Detection of Episodic Diversifying Selection

(2015) Martin D. Smith et al.   MOLECULAR BIOLOGY AND EVOLUTION

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

(2015) Pedro Escoll et al.   NATURE REVIEWS MICROBIOLOGY

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Native structure of a type IV secretion system core complex essential for Legionella pathogenesis

(2014) T. Kubori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FUBAR: A Fast, Unconstrained Bayesian AppRoximation for Inferring Selection

(2013) B. Murrell et al.   MOLECULAR BIOLOGY AND EVOLUTION

Reassessing the Role of DotF in the Legionella pneumophila Type IV Secretion System

(2013) Molly C. Sutherland et al.   PLoS One

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal

(2013) Z. Lifshitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IcmQ in the Type 4b Secretion System Contains an NAD+ Binding Domain

(2013) Jeremiah D. Farelli et al.   STRUCTURE

Functional Plasticity in the Type IV Secretion System of Helicobacter pylori

(2013) Roberto M. Barrozo et al.   PLoS Pathogens

Evolution of Conjugation and Type IV Secretion Systems

(2012) Julien Guglielmini et al.   MOLECULAR BIOLOGY AND EVOLUTION

Identification of the DotL coupling protein subcomplex of the Legionella Dot/Icm type IV secretion system

(2012) Carr D. Vincent et al.   MOLECULAR MICROBIOLOGY

Detecting Individual Sites Subject to Episodic Diversifying Selection

(2012) Ben Murrell et al.   PLoS Genetics

The Legionella IcmSW Complex Directly Interacts with DotL to Mediate Translocation of Adaptor-Dependent Substrates

(2012) Molly C. Sutherland et al.   PLoS Pathogens

Analysing recombination in nucleotide sequences

(2011) DARREN P. MARTIN et al.   Molecular Ecology Resources

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

Comprehensive Identification of Protein Substrates of the Dot/Icm Type IV Transporter of Legionella pneumophila

(2011) Wenhan Zhu et al.   PLoS One

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

(2011) Laura Gomez-Valero et al.   Frontiers in Microbiology

Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria

(2011) Hiroki Nagai et al.   Frontiers in Microbiology

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

The E Block motif is associated with Legionella pneumophila translocated substrates

(2010) Li Huang et al.   CELLULAR MICROBIOLOGY

Molecular Pathogenesis of Infections Caused by Legionella pneumophila

(2010) H. J. Newton et al.   CLINICAL MICROBIOLOGY REVIEWS

Crystal Structure of Legionella DotD: Insights into the Relationship between Type IVB and Type II/III Secretion Systems

(2010) Noboru Nakano et al.   PLoS Pathogens

Structure and Function of Interacting IcmR-IcmQ Domains from a Type IVb Secretion System in Legionella pneumophila

(2009) Suchismita Raychaudhury et al.   STRUCTURE

Genome-Scale Identification of Legionella pneumophila Effectors Using a Machine Learning Approach

(2009) David Burstein et al.   PLoS Pathogens

Outer-membrane proteomic maps and surface-exposed proteins of Legionella pneumophila using cellular fractionation and fluorescent labelling

(2008) A. Khemiri et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery

(2008) M. Garcia-Boronat et al.   NUCLEIC ACIDS RESEARCH

The Population Genetics of dN/dS

(2008) Sergey Kryazhimskiy et al.   PLoS Genetics

Diversifying Selection and Concerted Evolution of a Type IV Secretion System in Bartonella

(2007) B. Nystedt et al.   MOLECULAR BIOLOGY AND EVOLUTION