Article
Endocrinology & Metabolism
Rachana Eshwaran, Matthias Kolibabka, Gernot Poschet, Gregor Jainta, Di Zhao, Loic Teuma, Katharina Murillo, Hans-Peter Hammes, Martina Schmidt, Thomas Wieland, Yuxi Feng
Summary: The study found that glucosamine may have a protective effect on diabetic retinopathy, but may cause damage to the blood vessels in the normal retina.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Yimeng Sun, Feng Wen, Chun Yan, Lishi Su, Jiawen Luo, Wei Chi, Shaochong Zhang
Summary: Anti-VEGF drug bevacizumab may induce retinal hypoxia, but it also activates the HIF-1 alpha-BNIP3/FUNDC1 signaling pathway, leading to mitophagy that reduces oxidative stress and alleviates the deleterious effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Critical Care Medicine
Laura Brabenec, Melanie Mueller, Katharina E. M. Hellenthal, Ole S. Karsten, Heorhii Pryvalov, Mandy Otto, Anna Holthenrich, Anna L. Linard Matos, Raphael Weiss, Sebastian Kintrup, Michael Hessler, Angelo Dell'Aquila, Katharina Thomas, Johannes Nass, Andreas Margraf, Astrid F. Nottebaum, Jan Rossaint, Alexander Zarbock, Dietmar Vestweber, Volker Gerke, Nana-Maria Wagner
Summary: Procalcitonin induces endothelial hyperpermeability by destabilizing VE-cadherin, and targeting procalcitonin can protect vascular barrier integrity.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Priyamvada M. Pitale, Marina S. Gorbatyuk
Summary: Diabetic retinopathy is a complex ocular complication of diabetes with a mechanism that is still under investigation. Animal models have contributed significantly to the understanding of retinopathy, but better models are needed to mimic the neurovascular pathobiological features observed in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Chun-lin Zhang, Hai-ling Wang, Peng-cheng Li, Can-dong Hong, An-qi Chen, Yan-mei Qiu, Ai-ping Zeng, Yi-fan Zhou, Bo Hu, Ya-nan Li
Summary: Research suggests that the failure of DHA therapy in some patients with diabetic retinopathy (DR) is associated with low expression of Mfsd2a, and the combination of Mfsd2a overexpression with DHA therapy may be an effective treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Ophthalmology
Shuizhen Shi, Chun Ding, Shuang Zhu, Fan Xia, Seth E. Buscho, Shengguo Li, Massoud Motamedi, Hua Liu, Wenbo Zhang
Summary: In this study, the role of PERK in ischemia-induced retinopathy was investigated using a mouse model of oxygen-induced retinopathy (OIR). The results showed that inhibition of PERK reduced retinal neovascularization and retinal ganglion cell loss, restored astrocyte network, and promoted revascularization. Therefore, PERK inhibition may provide an effective therapeutic intervention for alleviating retinal neovascularization and preventing neuron loss during retinal ischemia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Koki Watanabe, Daiki Asano, Hiroko Ushikubo, Akane Morita, Asami Mori, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara
Summary: Metformin can protect against NMDA-induced retinal neurotoxicity by activating the AMPK and MEK/ERK signaling pathways in rats. This neuroprotective effect may be partially due to inhibitory effects on inflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Linhe Lu, Jipeng Ma, Yang Liu, Yalan Shao, Xiang Xiong, Weixun Duan, Erhe Gao, Qianli Yang, Shasha Chen, Jian Yang, Jun Ren, Qijun Zheng, Jincheng Liu
Summary: In this study, it was shown that FSTL1 could protect T2DM patients against cardiac dysfunction following myocardial infarction by activating the USP10/Notch1 signaling pathway. The findings suggest the clinical relevance and therapeutic potential of FSTL1 in T2DM-associated myocardial infarction and other cardiovascular diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Makoto Tagaya, Shinji Kume, Mako Yasuda-Yamahara, Shogo Kuwagata, Kosuke Yamahara, Naoko Takeda, Yuki Tanaka, Masami Chin-Kanasaki, Yuki Nakae, Hideki Yokoi, Masashi Mukoyama, Naotada Ishihara, Masatoshi Nomura, Shin-ichi Araki, Hiroshi Maegawa
Summary: The mechanisms underlying the progression from endothelial damage to podocyte damage in diabetic kidney disease (DKD) and the development of massive proteinuria are investigated. Dynamin-related protein 1 (Drp1)-mediated regulation of mitochondrial fission in podocytes plays a role in the pathogenesis of proteinuria in DKD. Inhibition of mitochondrial fission in podocytes may represent a new therapeutic strategy for massive proteinuria in DKD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Mikhail V. Samsonov, Nikita V. Podkuychenko, Asker Y. Khapchaev, Eugene E. Efremov, Elena V. Yanushevskaya, Tatiana N. Vlasik, Vadim Z. Lankin, Iurii S. Stafeev, Maxim V. Skulachev, Marina V. Shestakova, Alexander V. Vorotnikov, Vladimir P. Shirinsky
Summary: Hyperlipidemia, characterized by high levels of FFA and lipoprotein triglycerides, plays a critical role in the progression of T2D and cardiovascular complications. However, studying the effects of high FFA in endothelial culture often leads to cell apoptosis and fails to mimic the slow deterioration process in vivo. Our study shows that the typical FFA, palmitate (PA), does not impair endothelial barrier and insulin signaling on its own, but increases oxidative stress and lipid peroxidation. This eventually leads to cell death and loss of insulin signaling. Supplementation with AICAR protects against PA-induced oxidative stress and maintains cell viability and barrier function, providing a means to study the long-term effects of high FFA levels in endothelial cultures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Matthew W. Pitts, Lucia A. Seale, Jessica L. Nicholson, Pamela Toh, Jun Kyoung Kim, Marla J. Berry, Daniel J. Torres
Summary: The use of glucocorticoid medications can cause metabolic side effects such as overeating, weight gain, and insulin resistance. The hypothalamus, a regulator of feeding behavior and energy expenditure, is responsive to glucocorticoids and may play a role in metabolic defects. Selenium has been found to counter the effects of glucocorticoids and is important for hypothalamic function. This study aimed to investigate if selenium could protect hypothalamic cells from dysfunction caused by glucocorticoid exposure.
Article
Infectious Diseases
Dagmar Hildebrand, Jana Boehringer, Eva Koerner, Ute Chiriac, Sandra Foermer, Aline Saehr, Torsten Hoppe-Tichy, Klaus Heeg, Dennis Nurjadi
Summary: This study investigates the potential effect of cefiderocol on the barrier function of vascular endothelial cells. The results suggest that cefiderocol can reduce the permeability of intercellular gaps and decrease the release of inflammatory cytokines.
Article
Multidisciplinary Sciences
Sneha Mishra, Claudia Cosentino, Ankit Kumar Tamta, Danish Khan, Shalini Srinivasan, Venkatraman Ravi, Elena Abbotto, Bangalore Prabhashankar Arathi, Shweta Kumar, Aditi Jain, Anand S. Ramaian, Shruti M. Kizkekra, Raksha Rajagopal, Swathi Rao, Swati Krishna, Ninitha Asirvatham-Jeyaraj, Elizabeth R. Haggerty, Dafne M. Silberman, Irwin J. Kurland, Ravindra P. Veeranna, Tamilselvan Jayavelu, Santina Bruzzone, Raul Mostoslavsky, Nagalingam R. Sundaresan
Summary: Chronic stress leads to skeletal muscle wasting by increasing glucocorticoid levels. The study demonstrates that SIRT6 plays a role in regulating glucocorticoid-induced muscle atrophy by modulating the IGF/PI3K/AKT signaling pathway. Overexpression of SIRT6 reduces the size of myotubes, while depletion of SIRT6 protects against glucocorticoid-induced reduction in myotube size. SIRT6 deficiency hyperactivates IGF/PI3K/AKT signaling, leading to repression of the FoxO transcription factor, an important regulator of muscle atrophy.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Grazia Maugeri, Claudio Bucolo, Filippo Drago, Settimio Rossi, Michelino Di Rosa, Rosa Imbesi, Velia D'Agata, Salvatore Giunta
Summary: The study showed that DMF provides significant protection against high glucose-induced damage in RPE cells by inhibiting p38 MAPK and downregulating VEGF levels. This suggests that DMF is a promising candidate for diabetic retinopathy treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Md Badrul Alam, Jeong-Sic Ra, Ji-Young Lim, Bo-Rim Song, Ahsan Javed, Sang-Han Lee
Summary: The study found that lariciresinol (LSR) has an antidiabetic effect. LSR inhibits the activity of α-glucosidase and promotes glucose uptake by activating insulin signaling. In diabetic mice, LSR treatment significantly reduces blood glucose levels, increases insulin levels, improves pancreatic islet size, enhances insulin signaling in skeletal muscle, and activates glycogen synthase kinase 3 beta (GSK-3 beta) to increase glycogen content. These findings suggest a potential usefulness of oral LSR in the management and prevention of diabetes.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Letter
Ophthalmology
Chelsea E. Myers, Barbara E. K. Klein, Ronald Klein
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2015)
Editorial Material
Endocrinology & Metabolism
Barbara E. K. Klein, Ronald Klein
Letter
Ophthalmology
Stacy M. Meuer, Barbara E. K. Klein, Chelsea E. Myers, Ronald Klein
Article
Ophthalmology
Diana E. Fisher, Fridbert Jonasson, Gudny Eiriksdottir, Sigurdur Sigurdsson, Ronald Klein, Lenore J. Launer, Vilmundur Gudnason, Mary Frances Cotch
Article
Ophthalmology
Stacy M. Meuer, Chelsea E. Myers, Barbara E. K. Klein, Maria K. Swift, Yijun Huang, Sapna Gangaputra, Jeong W. Pak, Ronald P. Danis, Ronald Klein
Article
Ophthalmology
Farzana Choudhury, Stacy M. Meuer, Ronald Klein, Dandan Wang, Mina Torres, Xuejuan Jiang, Roberta Mckean-Cowdin, Rohit Varma
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2018)
Article
Ophthalmology
Ronald Klein, Kristine E. Lee, Lorraine Danforth, Michael Y. Tsai, Ronald E. Gangnon, Stacy E. Meuer, Tien Y. Wong, Carol Y. Cheung, Barbara E. K. Klein
Article
Endocrinology & Metabolism
Tamara J. LeCaire, Barbara E. K. Klein, Kerri P. Howard, Kristine E. Lee, Ronald Klein
Article
Endocrinology & Metabolism
Nasrin Azad, Lily Agrawal, Nicholas V. Emanuele, Ronald Klein, Gideon D. Bahn, Madeline McCarren, Peter Reaven, Rodney Hayward, William Duckworth
Article
Ophthalmology
Jie Jin Wang, Gabrielle H. S. Buitendijk, Elena Rochtchina, Kristine E. Lee, Barbara E. K. Klein, Cornelia M. van Duijn, Victoria M. Flood, Stacy M. Meuer, John Attia, Chelsea Myers, Elizabeth G. Holliday, Ava G. Tan, Wayne T. Smith, Sudha K. Iyengar, Paulus T. V. M. de Jong, Albert Hofman, Johannes R. Vingerling, Paul Mitchell, Ronald Klein, Caroline C. W. Klaver
Article
Multidisciplinary Sciences
Antonio B. Fernandez, Kevin D. Ballard, Tien Y. Wong, Mengye Guo, Robyn L. McClelland, Gregory Burke, Mary Frances Cotch, Barbara Klein, Matthew Allison, Ronald Klein
Article
Ophthalmology
Ronald Klein, Kristine E. Lee, Michael Y. Tsai, Karen J. Cruickshanks, Ronald E. Gangnon, Barbara E. K. Klein
Article
Rheumatology
Helgi Jonsson, Diana E. Fisher, Gudny Eiriksdottir, Thor Aspelund, Ronald Klein, Vilmundur Gudnason, Mary Frances Cotch
RHEUMATOLOGY INTERNATIONAL
(2019)
Article
Medicine, General & Internal
William Jones Dartora, Marcelo Krieger Maestri, Maria Ines Schmidt, Bruce Bartholow Duncan, Lloyd Chambless, Ronald Klein, Stacy Meuer, Vivian Cristine Luft
SAO PAULO MEDICAL JOURNAL
(2018)
Letter
Endocrinology & Metabolism
Ronald Klein, Kayla Horak, Kristine E. Lee, Lorraine Danforth, Karen J. Cruickshanks, Michael Y. Tsai, Ronald E. Gangnon, Barbara E. K. Klein