Epigenetic priming sensitizes gastric cancer cells to irinotecan and cisplatin by restoring multiple pathways

LINC00162 confers sensitivity to 5-Aza-2′-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1

(2019) Liang Zong et al.   ONCOGENE

Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

(2018) Kohei Shitara et al.   LANCET

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues

(2018) Satoshi Yamashita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer

(2018) Alessandro Annibaldi et al.   TRENDS IN MOLECULAR MEDICINE

MACON: a web tool for computing DNA methylation data obtained by the Illumina Infinium Human DNA methylation BeadArray

(2018) Naoko Iida et al.   Epigenomics

Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Yoon-Koo Kang et al.   LANCET

Mitoxantrone, etoposide and cytarabine following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: a phase 1/2 study

(2017) A B Halpern et al.   LEUKEMIA

Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells

(2017) Anup Sharma et al.   PLoS One

Phase I Study of Epigenetic Priming with Azacitidine Prior to Standard Neoadjuvant Chemotherapy for Patients with Resectable Gastric and Esophageal Adenocarcinoma: Evidence of Tumor Hypomethylation as an Indicator of Major Histopathologic Response

(2016) Bryan J. Schneider et al.   CLINICAL CANCER RESEARCH

High impact of methylation accumulation on metachronous gastric cancer: 5-year follow-up of a multicentre prospective cohort study

(2016) Masahiro Maeda et al.   GUT

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancers

(2016) Jeannine Diesch et al.   Clinical Epigenetics

A Recombinant Reporter System for Monitoring Reactivation of an Endogenously DNA Hypermethylated Gene

(2014) Y. Cui et al.   CANCER RESEARCH

Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer

(2014) Yukie Yoda et al.   Gastric Cancer

Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study

(2014) Kiyoshi Asada et al.   GUT

Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial

(2014) Hansjochen Wilke et al.   LANCET ONCOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function

(2013) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells

(2012) Hsing-Chen Tsai et al.   CANCER CELL

Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers

(2012) Jeong Goo Kim et al.   CANCER LETTERS

Epigenetic Resensitization to Platinum in Ovarian Cancer

(2012) D. Matei et al.   CANCER RESEARCH

RUNX family: Regulation and diversification of roles through interacting proteins

(2012) Linda Shyue Huey Chuang et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of a DNA methylation marker that detects the presence of lymph node metastases of gastric cancers

(2012) YASUYUKI SHIGEMATSU et al.   Oncology Letters

Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML

(2011) J. M. Scandura et al.   BLOOD

High density DNA methylation array with single CpG site resolution

(2011) Marina Bibikova et al.   GENOMICS

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation

(2010) Keun Hur et al.   CARCINOGENESIS

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER