RUNX family: Regulation and diversification of roles through interacting proteins

Gastrointestinal Adenocarcinomas of the Esophagus, Stomach, and Colon Exhibit Distinct Patterns of Genome Instability and Oncogenesis

(2012) A. M. Dulak et al.   CANCER RESEARCH

RUNX3 interactome reveals novel centrosomal targeting of RUNX family of transcription factors

(2012) Linda Shyue Huey Chuang et al.   CELL CYCLE

RUNX3 is expressed in the epithelium of the gastrointestinal tract

(2012) Yoshiaki Ito   EMBO Molecular Medicine

Stabilization of RNT-1 Protein, Runt-related Transcription Factor (RUNX) Protein Homolog of Caenorhabditis elegans , by Oxidative Stress through Mitogen-activated Protein Kinase Pathway

(2012) Kiho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors

(2012) Ming Yu et al.   MOLECULAR CELL

Sequence analysis of mutations and translocations across breast cancer subtypes

(2012) Shantanu Banerji et al.   NATURE

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

(2012) Giusy Della Gatta et al.   NATURE MEDICINE

Runx3 Protects Gastric Epithelial Cells Against Epithelial-Mesenchymal Transition-Induced Cellular Plasticity and Tumorigenicity

(2012) Dominic Chih-Cheng Voon et al.   STEM CELLS

Epigenetic changes induced by oxidative stress in colorectal cancer cells: methylation of tumor suppressor RUNX3

(2012) Kyoung Ah Kang et al.   TUMOR BIOLOGY

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

(2011) G. Huang et al.   BLOOD

Runx3 is a crucial regulator of alveolar differentiation and lung tumorigenesis in mice

(2011) Jong-Min Lee et al.   DIFFERENTIATION

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function

(2011) Ditsa Levanon et al.   EMBO Molecular Medicine

The origin of pre-neoplastic metaplasia in the stomach: Chief cells emerge from the Mist

(2011) James R. Goldenring et al.   EXPERIMENTAL CELL RESEARCH

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

(2011) Kentson Lam   Frontiers in Bioscience-Landmark

Loss of Runx3 Is a Key Event in Inducing Precancerous State of the Stomach

(2011) Kosei Ito et al.   GASTROENTEROLOGY

Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein

(2011) Ken-ichi Inoue et al.   GENE

Genome profiling of pancreatic adenocarcinoma

(2011) David J. Birnbaum et al.   GENES CHROMOSOMES & CANCER

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

(2011) Siân Jones et al.   HUMAN MUTATION

Identification of RUNX3 as a component of the MST/Hpo signaling pathway

(2011) Boram Min et al.   JOURNAL OF CELLULAR PHYSIOLOGY

RUNX3 methylation as a predictor for disease progression in patients with non-muscle-invasive bladder cancer

(2011) Chunri Yan et al.   JOURNAL OF SURGICAL ONCOLOGY

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

(2011) Kai Wang et al.   NATURE GENETICS

RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

(2011) B Huang et al.   ONCOGENE

Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3–p300 interaction

(2010) Kazunori Iwatani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Runx1 and Runx2 cooperate during sternal morphogenesis

(2010) A. Kimura et al.   DEVELOPMENT

Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages

(2010) Carmen G Palii et al.   EMBO JOURNAL

RUNX1translocations and fusion genes in malignant hemopathies

(2010) Etienne De Braekeleer et al.   Future Oncology

RUNX3 Modulates DNA Damage-mediated Phosphorylation of Tumor Suppressor p53 at Ser-15 and Acts as a Co-activator for p53

(2010) Chizu Yamada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm

(2010) Yun-Mi Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of RUNX1 by Cyclin-dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3

(2010) Hong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOX9 determines RUNX2 transactivity by directing intracellular degradation

(2010) Aixin Cheng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Control of RUNX3 by histone methyltransferases

(2010) You Mie Lee   JOURNAL OF CELLULAR BIOCHEMISTRY

The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes

(2010) Rachit Bakshi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

(2010) Balca R. Mardin et al.   NATURE CELL BIOLOGY

Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer

(2010) K-S Lee et al.   ONCOGENE

RUNX3 is multifunctional in carcinogenesis of multiple solid tumors

(2010) L S H Chuang et al.   ONCOGENE

Helicobacter pylori CagA targets gastric tumor suppressor RUNX3 for proteasome-mediated degradation

(2010) Y H Tsang et al.   ONCOGENE

The Core Binding Factor CBF Negatively Regulates Skeletal Muscle Terminal Differentiation

(2010) Ophélie Philipot et al.   PLoS One

Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma

(2010) Siân Jones et al.   SCIENCE

CHIP functions an E3 ubiquitin ligase of Runx1

(2009) Yu Shang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Post-translational modifications of Runx1 regulate its activity in the cell

(2009) Lan Wang et al.   BLOOD CELLS MOLECULES AND DISEASES

Runt-Related Transcription Factor RUNX3 Is a Target of MDM2-Mediated Ubiquitination

(2009) X.-Z. Chi et al.   CANCER RESEARCH

RUNX3 directly interacts with intracellular domain of Notch1 and suppresses Notch signaling in hepatocellular carcinoma cells

(2009) Juan Gao et al.   EXPERIMENTAL CELL RESEARCH

Claudin-1 Has Tumor Suppressive Activity and Is a Direct Target of RUNX3 in Gastric Epithelial Cells

(2009) Ti Ling Chang et al.   GASTROENTEROLOGY

PTHrP prevents chondrocyte premature hypertrophy by inducing cyclin-D1-dependent Runx2 and Runx3 phosphorylation, ubiquitylation and proteasomal degradation

(2009) M. Zhang et al.   JOURNAL OF CELL SCIENCE

Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors

(2009) Xiaodong Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Jab1/CSN5 induces the cytoplasmic localization and degradation of RUNX3

(2009) Jang-Hyun Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

RUNX3-mediated repression of RUNX1 in B cells

(2009) Gareth Brady et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell cycle and developmental control of hematopoiesis by Runx1

(2009) Alan D. Friedman   JOURNAL OF CELLULAR PHYSIOLOGY

Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation

(2009) G. Brady et al.   JOURNAL OF VIROLOGY

RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress

(2009) K Wolyniec et al.   ONCOGENE

PEBP2- /CBF- -dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

(2008) H.-J. Wee et al.   BLOOD

The evolutionary origin of the Runx/CBF-beta transcription factors - studies of the most basal metazoans

(2008) James C Sullivan et al.   BMC EVOLUTIONARY BIOLOGY

RUNX3 Attenuates β-Catenin/T Cell Factors in Intestinal Tumorigenesis

(2008) Kosei Ito et al.   CANCER CELL

RUNX3 Methylation Reveals that Bladder Tumors Are Older in Patients with a History of Smoking

(2008) E. M. Wolff et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Wnt/β-catenin signaling: new (and old) players and new insights

(2008) He Huang et al.   CURRENT OPINION IN CELL BIOLOGY

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

(2008) Shinsuke Ohba et al.   DEVELOPMENTAL CELL

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

(2008) X. Zhao et al.   GENES & DEVELOPMENT

Physical and Functional Interactions between STAT5 and Runx Transcription Factors

(2008) Shinya Ogawa et al.   JOURNAL OF BIOCHEMISTRY

A Regulatory Circuit Controlling Itch-mediated p73 Degradation by Runx

(2008) Dan Levy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancer of Zeste Homologue 2 (EZH2) Down-regulates RUNX3 by Increasing Histone H3 Methylation

(2008) Satoshi Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors

(2008) Nadiya M. Teplyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor Receptor-associated Factor 6 Is an Intranuclear Transcriptional Coactivator in Osteoclasts

(2008) Shuting Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

(2008) Xueni Li et al.   JOURNAL OF CELL BIOLOGY

E1A physically interacts with RUNX3 and inhibits its transactivation activity

(2008) Eun-Jeong Cha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization

(2008) Hye-Ryun Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes

(2008) Sandhya Pande et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

Arginine Methylation of FOXO Transcription Factors Inhibits Their Phosphorylation by Akt

(2008) Kazuyuki Yamagata et al.   MOLECULAR CELL

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis

(2008) R A Eliseev et al.   ONCOGENE

Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells

(2008) S H Lee et al.   ONCOGENE