ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions

A sputum 6-gene signature predicts future exacerbations of poorly controlled asthma

(2019) Michael Fricker et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma

(2019) Richard Beasley et al.   NEW ENGLAND JOURNAL OF MEDICINE

β2-Agonists Enhance Asthma-Relevant Inflammatory Mediators in Human Airway Epithelial Cells

(2018) Andrew I. Ritchie et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle

(2018) Donghwa Kim et al.   FASEB JOURNAL

More than a decade follow-up in patients with severe or difficult-to-treat asthma: The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) II

(2018) Bradley E. Chipps et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles

(2018) Michael A. Ghebre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The obese-asthma phenotype in children: An exacerbating situation?

(2018) Cristina Longo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A pilot randomized controlled trial on the impact of text messaging check-ins and a web-based asthma action plan versus a written action plan on asthma exacerbations

(2018) Iraj Poureslami et al.   JOURNAL OF ASTHMA

Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma

(2018) Paul M. O’Byrne et al.   NEW ENGLAND JOURNAL OF MEDICINE

As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma

(2018) Eric D. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations

(2018) Tricia McKeever et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

(2018) Klaus F. Rabe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

(2018) Mario Castro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis

(2018) Helen L Petsky et al.   THORAX

Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS): a multicentre, double-blind, randomised, placebo-controlled phase 2 trial

(2018) Richard J Russell et al.   Lancet Respiratory Medicine

Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies

(2018) J Mark FitzGerald et al.   Lancet Respiratory Medicine

Consequences of long-term OCS therapy and its side effects in severe asthma in adults – A focused review of the impact data in the literature

(2018) Timm Volmer et al.   EUROPEAN RESPIRATORY JOURNAL

Asthma phenotypes: do cough and wheeze predict exacerbations in persistent asthma?

(2017) Jaymin B. Morjaria et al.   EUROPEAN RESPIRATORY JOURNAL

U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics

(2017) Diane Lefaudeux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial

(2017) Peter G Gibson et al.   LANCET

Oral Glucocorticoid–Sparing Effect of Benralizumab in Severe Asthma

(2017) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tezepelumab in Adults with Uncontrolled Asthma

(2017) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

MyAirCoach: the use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; study protocol of an observational study

(2017) Persijn J Honkoop et al.   BMJ Open

Managing asthma in the era of biological therapies

(2017) Philip G Bardin et al.   Lancet Respiratory Medicine

Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial

(2017) Geoffrey L Chupp et al.   Lancet Respiratory Medicine

Asthma Exacerbations: Pathogenesis, Prevention, and Treatment

(2017) Jamee R. Castillo et al.   Journal of Allergy and Clinical Immunology-In Practice

Near Fatal Asthma in an Inner City Population

(2016) Viral Doshi et al.   AMERICAN JOURNAL OF THERAPEUTICS

Long-term Efficacy and Safety of Mepolizumab in Patients With Severe Eosinophilic Asthma: A Multi-center, Open-label, Phase IIIb Study

(2016) Njira Lugogo et al.   CLINICAL THERAPEUTICS

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

(2016) Eugene R Bleecker et al.   LANCET

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Respiratory virus transmission dynamics determine timing of asthma exacerbation peaks: Evidence from a population-level model

(2016) Rosalind M. Eggo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The asthma-anxiety connection

(2016) Stefano R. Del Giacco et al.   RESPIRATORY MEDICINE

Identifying patients at risk for severe exacerbations of asthma: development and external validation of a multivariable prediction model

(2016) Rik J B Loymans et al.   THORAX

Factors associated with failure of emergency department management in children with acute moderate or severe asthma: a prospective, multicentre, cohort study

(2016) Francine M Ducharme et al.   Lancet Respiratory Medicine

Fevipiprant, a prostaglandin D 2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial

(2016) Sherif Gonem et al.   Lancet Respiratory Medicine

Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(2016) Nicola A Hanania et al.   Lancet Respiratory Medicine

Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies

(2016) Hector G Ortega et al.   Lancet Respiratory Medicine

Identification and characterization of near-fatal asthma phenotypes by cluster analysis

(2015) J. Serrano-Pariente et al.   ALLERGY

A randomized trial of benralizumab, an antiinterleukin 5 receptor α monoclonal antibody, after acute asthma

(2015) Richard M. Nowak et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Risk Factors for Frequent Severe Exacerbations in Late-Onset Eosinophilic Asthma

(2015) Jantina C. de Groot et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Characteristics and Prognosis of Near-Fatal Asthma Exacerbations

(2015) Francisco-Javier Gonzalez-Barcala et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

The impact of anxiety and depression on outpatients with asthma

(2015) Giorgio Ciprandi et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Leukotriene-Receptor Antagonists Versus Placebo in the Treatment of Asthma in Adults and Adolescents

(2015) Michael Miligkos et al.   ANNALS OF INTERNAL MEDICINE

Rhinovirus in the Pathogenesis and Clinical Course of Asthma

(2015) Kyla C. Jamieson et al.   CHEST

Asthma is Different in Women

(2015) Joe G. Zein et al.   CURRENT ALLERGY AND ASTHMA REPORTS

A summary of the new GINA strategy: a roadmap to asthma control

(2015) Helen K. Reddel et al.   EUROPEAN RESPIRATORY JOURNAL

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

(2015) Stephen J. Teach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations

(2015) Eric D. Bateman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CTNNA3 and SEMA3D : Promising loci for asthma exacerbation identified through multiple genome-wide association studies

(2015) Michael J. McGeachie et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Aerobic training decreases bronchial hyperresponsiveness and systemic inflammation in patients with moderate or severe asthma: a randomised controlled trial

(2015) Andrezza França-Pinto et al.   THORAX

Challenges in developing a cross-serotype rhinovirus vaccine

(2015) Nicholas Glanville et al.   Current Opinion in Virology

The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial

(2015) Amy H Y Chan et al.   Lancet Respiratory Medicine

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

(2015) Mario Castro et al.   Lancet Respiratory Medicine

Blood eosinophil count and prospective annual asthma disease burden: a UK cohort study

(2015) David B Price et al.   Lancet Respiratory Medicine

Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women

(2014) K. Heikkilä et al.   ALLERGY

Emergency department visits for acute asthma by adults who ran out of their inhaled medications

(2014) K. Hasegawa et al.   ALLERGY AND ASTHMA PROCEEDINGS

The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections. A Randomized Trial

(2014) Ratko Djukanović et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Risk factors, management and outcomes of patients admitted with near fatal asthma to a tertiary care hospital in Riyadh

(2014) HasanM Al-Dorzi et al.   Annals of Thoracic Medicine

International European Respiratory Society/American Thoracic Society guidelines on severe asthma

(2014) J. Bousquet et al.   EUROPEAN RESPIRATORY JOURNAL

Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12-month follow-up analysis

(2014) Pranabashis Haldar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhaler reminders improve adherence with controller treatment in primary care patients with asthma

(2014) Juliet M. Foster et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

(2014) Elisabeth H. Bel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Asthma Trajectories in Early Childhood: Identifying Modifiable Factors

(2014) Lidia Panico et al.   PLoS One

Asthma genetics and personalised medicine

(2014) Deborah A Meyers et al.   Lancet Respiratory Medicine

EAACI position statement on asthma exacerbations and severe asthma

(2013) A. Custovic et al.   ALLERGY

Development of a mouse model mimicking key aspects of a viral asthma exacerbation

(2013) Deborah L. Clarke et al.   CLINICAL SCIENCE

The role of small airway disease in asthma

(2013) Leif Bjermer   CURRENT OPINION IN PULMONARY MEDICINE

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Potential negative consequences of non-consented switch of inhaled medications and devices in asthma patients

(2013) U. S. Björnsdóttir et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma

(2013) Michael E. Wechsler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Decoding asthma: Translating genetic variation in IL33 and IL1RL1 into disease pathophysiology

(2013) Néomi S. Grotenboer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma

(2013) Michael Schatz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effectiveness of voriconazole in the treatment of Aspergillus fumigatus–associated asthma (EVITA3 study)

(2013) Joshua Agbetile et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

(2013) Klaus Bønnelykke et al.   NATURE GENETICS

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of theophylline plus salmeterol/fluticasone propionate combination therapy in patients with asthma

(2013) Hanxiang Nie et al.   RESPIRATORY MEDICINE

Detection of exacerbations in asthma based on electronic diary data: results from the 1-year prospective BIOAIR study

(2013) Maciej Kupczyk et al.   THORAX

Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial

(2013) Guy G Brusselle et al.   THORAX

Are inhaled longacting β2 agonists detrimental to asthma?

(2013) Donald W Cockcroft et al.   Lancet Respiratory Medicine

Adherence

(2012) Louis-Philippe Boulet et al.   CLINICS IN CHEST MEDICINE

IL-4 receptor polymorphisms predict reduction in asthma exacerbations during response to an anti–IL-4 receptor α antagonist

(2012) Rebecca E. Slager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Response to infections in patients with asthma and atopic disease: An epiphenomenon or reflection of host susceptibility?

(2012) Kristina M. James et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Deficient antiviral immune responses in childhood: Distinct roles of atopy and asthma

(2012) Simonetta Baraldo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma outcomes: Exacerbations

(2012) Anne Fuhlbrigge et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Asthma Control Test and Asthma Control Questionnaire for assessing asthma control: Systematic review and meta-analysis

(2012) Chun E. Jia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fatal and Near-Fatal Asthma in Children: The Critical Care Perspective

(2012) Christopher J.L. Newth et al.   JOURNAL OF PEDIATRICS

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Tiotropium in Asthma Poorly Controlled with Standard Combination Therapy

(2012) Huib A.M. Kerstjens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry: Table 1

(2012) Joan Sweeney et al.   THORAX

Genome-wide association study to identify genetic determinants of severe asthma

(2012) Y I Wan et al.   THORAX

WHO universal definition of severe asthma

(2011) Andrew Bush et al.   Current Opinion in Allergy and Clinical Immunology

The genetics of asthma and allergic disease: a 21st century perspective

(2011) Carole Ober et al.   IMMUNOLOGICAL REVIEWS

Rhinoviruses, allergic inflammation, and asthma

(2011) Monica L. Gavala et al.   IMMUNOLOGICAL REVIEWS

Fluctuation phenotyping based on daily fraction of exhaled nitric oxide values in asthmatic children

(2011) Georgette Stern et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma exacerbations: Origin, effect, and prevention

(2011) David J. Jackson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence

(2011) L. Keoki Williams et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial

(2011) Heather Powell et al.   LANCET

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations

(2011) Carole Ober et al.   NATURE GENETICS

Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma

(2011) K. Perrin et al.   THORAX

The occupational contribution to severe exacerbation of asthma

(2010) P. K. Henneberger et al.   EUROPEAN RESPIRATORY JOURNAL

Overall asthma control: The relationship between current control and future risk

(2010) Eric D. Bateman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uniform definition of asthma severity, control, and exacerbations: Document presented for the World Health Organization Consultation on Severe Asthma

(2010) Jean Bousquet et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Severe asthma and adherence to peak flow monitoring: Longitudinal assessment of psychological aspects

(2010) Laurence Halimi et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

A Large-Scale, Consortium-Based Genomewide Association Study of Asthma

(2010) Miriam F. Moffatt et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effect of cigarette smoking on asthma control during exacerbations in pregnant women

(2010) V. E. Murphy et al.   THORAX

An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

(2009) Helen K. Reddel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

(2009) Mario Castro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Race/Ethnicity Differences in the Inpatient Management of Acute Asthma in the United States

(2009) Divay Chandra et al.   CHEST

The Strategy for Predicting Future Exacerbation of Asthma Using a Combination of the Asthma Control Test and Lung Function Test

(2009) Ryuji Sato et al.   JOURNAL OF ASTHMA

Modifiable Risk Factors for Asthma Morbidity in Bronx Versus Other Inner-City Children

(2009) Karen Warman et al.   JOURNAL OF ASTHMA

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Severe Exacerbations and Decline in Lung Function in Asthma

(2008) Paul M. O'Byrne et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial

(2008) Stanley J Szefler et al.   LANCET

Modifiable Risk Factors for Suboptimal Control and Controller Medication Underuse Among Children With Asthma

(2008) L. A. Smith et al.   PEDIATRICS