Review
Allergy
Birgit Pfaller, Sarah Bendien, Agnes Ditisheim, Thomas Eiwegger
Summary: Managing allergic diseases during pregnancy presents challenges and potential risks for mother and child, especially with limited safety data on anti-allergic drugs during pregnancy.
Review
Microbiology
Juanjuan Lyu, Fangfang Kou, Xiangyu Men, Yinhui Liu, Li Tang, Shu Wen
Summary: Complex changes in the microbiota of the respiratory and intestinal tracts in patients with allergic respiratory diseases are associated with immune disorders and could potentially be targeted for therapy.
Review
Immunology
Mohammad-Hossein Shams, Reza Jafari, Nahid Eskandari, Mohsen Masjedi, Farnaz Kheirandish, Mazdak Ganjalikhani Hakemi, Ramin Ghasemi, Ali-Mohammad Varzi, Seyyed-Mohsen Sohrabi, Peyman Amanolahi Baharvand, Mozhgan Safari
Summary: Allergic diseases have significantly increased globally in recent decades, influenced by genetic factors, industrialization, improved hygiene, and climate change. Changes in lifestyle and diet habits also play a key role in the prevalence of allergic diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Bo Yoon Choi, Munsoo Han, Ji Won Kwak, Tae Hoon Kim
Summary: The pathogenesis of allergic rhinitis is closely associated with genetic, environmental, and epigenetic factors. Genotyping of single nucleotide polymorphisms is an advanced technique in molecular genetics that is related to genome-wide association studies. Recent studies have focused on the impact of epigenetic factors such as DNA methylation, histone acetylation, and miRNA levels in the development of allergic rhinitis.
Review
Immunology
Haocheng Zheng, Yi Zhang, Jiachuang Pan, Nannan Liu, Yu Qin, Linghui Qiu, Min Liu, Tieshan Wang
Summary: Allergic diseases have been on the rise due to environmental changes and social development, leading to a significant public health burden. Recent studies suggest that ILC2s play important roles in allergic diseases, but further research is needed to fully understand their impact and potential treatment avenues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maya Berlin, Hadar Flor-Hirsch, Elkana Kohn, Anna Brik, Rimona Keidar, Ayelet Livne, Ronella Marom, Amit Ovental, Dror Mandel, Ronit Lubetzky, Pam Factor-Litvak, Josef Tovbin, Moshe Betser, Miki Moskovich, Ariela Hazan, Malka Britzi, Itai Gueta, Matitiahu Berkovitch, Ilan Matok, Uri Hamiel
Summary: The study aimed to investigate the association between maternal PCBs levels and atopic reactions in their offspring. The findings showed no significant association between exposure to PCBs and asthma, allergic rhinitis, or atopic dermatitis in children. More multi-participant studies with longer follow-up into later pediatric age are needed to further explore these relationships.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Allergy
Lucy E. Bradshaw, Laura A. Wyatt, Sara J. Brown, Rachel H. Haines, Alan A. Montgomery, Michael R. Perkin, Sandra Lawton, Tracey H. Sach, Joanne R. Chalmers, Matthew J. Ridd, Carsten Flohr, Joanne Brooks, Richard Swinden, Eleanor J. Mitchell, Stella Tarr, Nicola Jay, Kim S. Thomas, Hilary Allen, Michael J. Cork, Maeve M. Kelleher, Eric L. Simpson, Stella T. Lartey, Susan Davies-Jones, Robert J. Boyle, Hywel C. Williams
Summary: The study found that daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma, or hay fever. The difference in incidence rates of atopic dermatitis, food allergy, asthma, and hay fever between the emollient group and the control group was relatively small.
Article
Allergy
Peter Schmid-Grendelmeier, Melinda J. Gooderham, Karin Hartmann, George N. Konstantinou, Marc Fellmann, Christopher Koulias, Claire Clibborn, Pinaki Biswas, Patrick M. Brunner
Summary: This article evaluated the efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis and allergic comorbidities. The results showed that abrocitinib was effective and safe in managing atopic dermatitis in patients with or without allergic comorbidities.
Article
Allergy
Suleyman Tolga Yavuz, Ceyda Oksel Karakus, Adnan Custovic, Omer Kalayci
Summary: The study identified 4 phenotypes in school-age children with AR, which were associated with different patterns of clinical symptoms and comorbidities.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Immunology
Agnieszka Kaczynska, Martyna Klosinska, Kamil Janeczek, Michal Zarobkiewicz, Andrzej Emeryk
Summary: This article introduces the immunomodulatory effects of bacterial lysates (BLs) on allergic disorders, discusses the correlation between local, innate, and adaptive immune responses, and reviews the outcomes of BLs in the prevention and treatment of atopic dermatitis, allergic rhinitis, and asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Magnus Lindqvist, Katja Biering Leth-Moller, Allan Linneberg, Inger Kull, Anna Bergstrom, Antonios Georgellis, Magnus P. Borres, Agneta Ekebom, Marianne van Hage, Erik Melen, Marit Westman
Summary: Patients with pollen-induced allergic rhinitis face a high risk of persistent disease for at least 20 years, with childhood to adolescence being the most critical period for disease progression. The study findings underscore the close relationship between sensitization, allergic rhinitis, and asthma.
Review
Nutrition & Dietetics
Bartlomiej Morag, Patrycja Kozubek, Krzysztof Gomulka
Summary: Obesity, a global problem, is associated with negative health effects and has a relationship with allergic and immunological diseases. Treating diseases associated with obesity is challenging and drugs are less effective, requiring higher doses and posing higher risks for obese patients. Changing eating habits and increasing physical activity are the main forms of treatment, and reducing BMI has been proven beneficial in independent studies.
Article
Environmental Sciences
Juan Wang, Christer Janson, Andrei Malinovschi, Mathias Holm, Karl A. Franklin, Lars Modig, Ane Johannessen, Vivi Schluenssen, Thorarinn Gislason, Nils Oskar Jogi, Dan Norback
Summary: This study examined the relationship between home environment exposures and asthma, allergic rhinitis, and atopic dermatitis among offspring of participants in the Respiratory Health in Northern Europe (RHINE) study. The results showed that dampness/mold at home and living in new buildings were associated with asthma occurrence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Microbiology
Marcos Perez-Losada, Eduardo Castro-Nallar, Jose Laerte Boechat, Luis Delgado, Tiago Azenha Rama, Valentin Berrios-Farias, Manuela Oliveira
Summary: Allergic rhinitis and asthma lead to dysbiosis of nasal bacteriome, which can be potential biomarkers for diagnostics and therapeutics. This study provides insights into the distinct bacteriota in the nose during health and respiratory diseases.
Review
Pharmacology & Pharmacy
Kong Yen Liew, Nurain Irdayani Kamise, Hui Ming Ong, Poi Yi Aw Yong, Fahmida Islam, Ji Wei Tan, Chau Ling Tham
Summary: Allergic diseases are a global health burden, and the current available medications have side effects, poor perceived effectiveness, and high cost. Propolis, a natural herbal medicine with antioxidant, antimicrobial, and anticancer properties, has the potential to be a prophylactic or therapeutic option for allergic diseases. Preclinical studies have shown that propolis extracts have therapeutic effects on allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy by inhibiting mast cell and basophil activation. Clinically, propolis consumption as a supplement or adjunct therapy is safe and attenuates pathological conditions in asthma. Flavonoids and cinnamic acid derivatives in propolis contribute to its anti-allergic activities, but their presence varies in different propolis samples. Future studies should focus on the relationship between propolis's anti-allergic activity and its chemical contents.
FRONTIERS IN PHARMACOLOGY
(2022)
