Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3- b ]pyrazin-2(1 H )-ones as ligands for brain corticotropin-releasing factor type-1 (CRF 1 ) receptors

Published 2015 View Full Article

Title

Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3- b ]pyrazin-2(1 H )-ones as ligands for brain corticotropin-releasing factor type-1 (CRF 1 ) receptors

Authors

Keywords

Corticotropin-releasing factor, CRF-1 receptor, Fluorine-18, PET imaging, Positron emission tomography

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Volume 25, Issue 22, Pages 5111-5114

Publisher

Elsevier BV

Online

2015-10-14

DOI

10.1016/j.bmcl.2015.10.010

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