Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3- b ]pyrazin-2(1 H )-ones as ligands for brain corticotropin-releasing factor type-1 (CRF 1 ) receptors