Article
Environmental Sciences
Meng Li, Jing Feng, Ying Cheng, Nisha Dong, Xiaolin Tian, Penghui Liu, Yannan Zhao, Yulan Qiu, Fengjie Tian, Yi Lyu, Qian Zhao, Cailing Wei, Meng Wang, Jiyu Yuan, Xiaodong Ying, Xuefeng Ren, Xiaoyan Yan
Summary: Exposure to arsenic and fluoride induced early apoptosis and endoplasmic reticulum expansion in myocardial cells. Endoplasmic reticulum stress (ERS) and apoptosis pathways were involved in the damage caused by co-exposure to arsenic and fluoride.
Review
Pharmacology & Pharmacy
Huijie Zhao, Xiaodi Fu, Yanting Zhang, Yihan Yang, Honggang Wang
Summary: Endoplasmic reticulum (ER) plays a critical role in protein synthesis and processing. When ER is overloaded with misfolded proteins, ER stress is triggered. Hydrogen sulfide (H2S) has been recognized as an important gas signal molecule, with regulatory effects on various physiological and pathological processes. This review focuses on the role of H2S in regulating ER stress in myocardial diseases, aiming to provide a better understanding of its mechanisms.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Na Zhang, Lili Zhu, Xianxian Wu, Ru Yan, Shaobing Yang, Xiaoliang Jiang, Xing Liu, Xue Liu, Ning Yan, Guangzhi Cong, Zhiwei Yang, Shaobin Jia
Summary: Hyperhomocysteinemia aggravates atherosclerosis and plaque vulnerability through endoplasmic reticulum oxidoreductase 1 alpha, which is critical in ER stress-induced macrophage apoptosis and plaque stability.
Article
Biochemistry & Molecular Biology
Mengdie Luo, Emmanuel Opoku, C. Alicia Traughber, Qimin Hai, Peggy Robinet, Stela Berisha, Jonathan D. Smith
Summary: The study showed that AKR and DBA/2 mouse macrophages exhibit different levels of free cholesterol and CHOP expression after cholesterol loading due to variations in the Soat1 gene. Inhibition of ACAT enzyme revealed that differences in free cholesterol levels were responsible for the differential induction of CHOP.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Environmental Sciences
Jicang Wang, Lulu Ding, Ke Wang, Ruxue Huang, Wenjing Yu, Bingzhao Yan, Hongwei Wang, Cai Zhang, Zijun Yang, Zongping Liu
Summary: This study aimed to determine the protective effect of quercetin (Que) on cadmium (Cd)-induced hepatotoxicity. Through in vivo and in vitro experiments using rat models, the researchers found that Cd caused liver injury and cell apoptosis, and activated endoplasmic reticulum stress (ERS) signaling pathways. However, Que was able to improve hepatocyte vitality, reduce liver damage and oxidative stress caused by Cd.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Multidisciplinary Sciences
Mingyuan Fan, Jing Zhang, Lei Zeng, Danpeng Wang, Jiao Chen, Xiaorong Xi, Jing Long, Jinzhu Huang, Xueping Li
Summary: Apoptosis is a complex and self-regulating cell death form that plays an important role in the decline of ventricular function and the development of heart diseases. Endoplasmic reticulum stress is crucial in inducing apoptosis. Non-coding RNAs have been shown to regulate endoplasmic reticulum stress-induced cardiomyocyte injury and apoptosis. This study mainly discusses the effects of miRNA and LncRNA on endoplasmic reticulum stress in various heart diseases, aiming to clarify their protective effects and potential therapeutic strategies for apoptosis.
Article
Immunology
Huiling Chen, Suxin Luo, Huamei Chen, Cong Zhang
Summary: ATF3 downregulation reduces SPHK1 expression and attenuates cardiomyocyte injury in MI. Stimulation of activating transcription factor 3 (ATF3) exerts pro-fibrotic and proinflammatory effect and expedite endoplasmic reticulum (ER) stress in cardiomyocytes via sphingosine kinase 1 (SPHK1). The inhibition of ATF3 and SPHK1 may have therapeutic potential for MI.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Food Science & Technology
Jing Zhang, Qingbo Zhao, Zhihui Xue, Siyi Zhang, Zeyu Ren, Shaokui Chen, Ao Zhou, Hongbo Chen, Yulan Liu
Summary: This study reveals the involvement of endoplasmic reticulum (ER) stress in porcine macrophage cell apoptosis induced by Deoxynivalenol (DON). DON exposure leads to upregulation of ER stress-related genes and activates the IRE1/JNK/CHOP pathway, resulting in cellular apoptosis. The ER stress inhibitor 4-phenylbutyric acid (4-PBA) alleviates DON-induced ER stress and apoptosis.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Ziwei Zhu, Jie Pu, Yongnan Li, Jianshu Chen, Hong Ding, Anyu Zhou, Xiaowei Zhang
Summary: This study aimed to investigate the mechanism of RNA-binding protein RBM25 in ischemic heart failure (HF). The results showed that RBM25 was significantly upregulated in ischemic HF rat hearts and oxygen-glucose deprivation models, leading to cell apoptosis and cardiac dysfunction through the CHOP pathway of endoplasmic reticulum stress. Inhibiting RBM25 expression improved cardiac apoptosis and function. Therefore, RBM25 may be a potential therapeutic target for ischemic HF.
CELL STRESS & CHAPERONES
(2023)
Article
Biochemistry & Molecular Biology
Shi-Zheng Jia, Xin-Wen Xu, Zhong-Hao Zhang, Chen Chen, Yu-Bin Chen, Shao-Ling Huang, Qiong Liu, Peter R. Hoffmann, Guo-Li Song
Summary: Selenoprotein K plays a critical role in regulating intracellular calcium flux, degradation pathways, and response to stress in neurons. Knockout of SELENOK in neurons leads to increased apoptosis, activated cascade pathways, and decreased cognitive ability and increased anxiety in older mice.
Article
Biochemistry & Molecular Biology
Erdi Sozen, Tugce Demirel-Yalciner, Dyana Sari, Nesrin Kartal Ozer
Summary: Non-alcoholic fatty liver disease (NAFLD) is a major global health issue associated with obesity. This study reveals that cholesterol can induce ER stress and increase the expression of CHOP. Cholesterol accumulation in hepatocytes activates the IRE1/p38 pathway, leading to the development of NASH. Supplementation of alpha-tocopherol can inhibit the activation of IRE1/p38/CHOP and prevent NASH development.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Juan Ignacio Elio Mariangelo, Carlos Alfredo Valverde, Leticia Vittone, Matilde Said, Cecilia Mundina-Weilenmann
Summary: This study found that blocking ER calcium efflux via the translocon can suppress ER stress and improve the mechanical performance and diastolic calcium handling of stunned myocardium. Therefore, modulation of translocon permeability may be a therapeutic approach to treat the functional abnormalities caused by ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Ying Lu, Shou-ye Li, Hui Lou
Summary: Patchouli alcohol (PA) protects against myocardial ischemia/reperfusion (MI/R) injury by modulating endoplasmic reticulum stress, apoptosis, and the Notch1/Hes1 signaling pathway. These findings suggest that PA may be a potential drug for treating ischemic heart diseases.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)