Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input

标题
Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input
作者
关键词
Drug product, Dissolution, Mechanistic, Surface pH, Weak base, Prediction, Particle size, PBPK modelling
出版物
出版商
Elsevier BV
发表日期
2019-07-12
DOI
10.1016/j.ejpb.2019.07.014

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