Why has positive inotropy failed in chronic heart failure? Lessons from prior inotrope trials

Efficacy and safety of intermittent intravenous outpatient administration of levosimendan in patients with advanced heart failure: the LION-HEART multicentre randomised trial

(2018) Josep Comín-Colet et al.   EUROPEAN JOURNAL OF HEART FAILURE

Ambulatory Inotrope Infusions in Advanced Heart Failure

(2018) Tiana Nizamic et al.   JACC-Heart Failure

Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure

(2018) Muthiah Vaduganathan et al.   JACC-Heart Failure

Scheduled intermittent inotropes for Ambulatory Advanced Heart Failure. The RELEVANT-HF multicentre collaboration

(2018) Fabrizio Oliva et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Trifecta of Precision Care in Heart Failure

(2018) Tariq Ahmad et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Repetitive levosimendan treatment in the management of advanced heart failure

(2018) Fabrizio Oliva et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

Decision making in advanced heart failure: bench, bedside, practice, and policy

(2017) Daniel D. Matlock et al.   HEART FAILURE REVIEWS

Pharmacological reasons that may explain why randomized clinical trials have failed in acute heart failure syndromes

(2017) Juan Tamargo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study

(2017) A. Boswood et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Spironolactone Metabolites in TOPCAT — New Insights into Regional Variation

(2017) Simon de Denus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

(2017) Vicente J. Planelles-Herrero et al.   Nature Communications

Long-Term Effects of Flosequinan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure

(2017) Milton Packer et al.   JACC-Heart Failure

Metabolic support for the heart: complementary therapy for heart failure?

(2016) Ward A. Heggermont et al.   EUROPEAN JOURNAL OF HEART FAILURE

Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure

(2016) John R. Teerlink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support

(2016) Tariq Ahmad et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial

(2016) Barry Greenberg et al.   LANCET

Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial

(2016) John R Teerlink et al.   LANCET

Defining a Mobile Health Roadmap for Cardiovascular Health and Disease

(2016) Zubin J. Eapen et al.   Journal of the American Heart Association

Response to Letter Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"

(2015) J. P. Bakkehaug et al.   Circulation-Heart Failure

Letter by Teerlink et al Regarding Article, "Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity"

(2015) J. R. Teerlink et al.   Circulation-Heart Failure

Chronic Inotropic Therapy in the Current Era

(2015) Sean P. Pinney et al.   Circulation-Heart Failure

Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase ActivityCLINICAL PERSPECTIVE

(2015) Jens Petter Bakkehaug et al.   Circulation-Heart Failure

Safety and Tolerability of Omecamtiv Mecarbil During Exercise in Patients With Ischemic Cardiomyopathy and Angina

(2015) Barry H. Greenberg et al.   JACC-Heart Failure

The Use of Digoxin in Patients With Worsening Chronic Heart Failure

(2014) Andrew P. Ambrosy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical Implications of Chronic Heart Failure Phenotypes Defined by Cluster Analysis

(2014) Tariq Ahmad et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure

(2014) John J.V. McMurray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amrinone, Forerunner of Novel Cardiotonic Agents, Caused Paradigm Shift of Heart Failure Pharmacotherapy

(2013) Masao Endoh   CIRCULATION RESEARCH

Efficacy and Limitations of Oral Inotropic Agents for the Treatment of Chronic Heart Failure

(2013) Koji Murai et al.   International Heart Journal

Effect of Levosimendan on the Short-Term Clinical Course of Patients With Acutely Decompensated Heart Failure

(2013) Milton Packer et al.   JACC-Heart Failure

Dead Letter Office

(2013) Christopher O’Connor   JACC-Heart Failure

When the Heart Runs Out of Heartbeats

(2012) Tariq Ahmad et al.   CIRCULATION

Chronic Istaroxime Improves Cardiac Function and Heart Rate Variability in Cardiomyopathic Hamsters

(2011) Pietro Lo Giudice et al.   CARDIOVASCULAR DRUGS AND THERAPY

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Cardiac inotropes: current agents and future directions

(2011) G. Hasenfuss et al.   EUROPEAN HEART JOURNAL

Role and mechanism of subcellular Ca2+ distribution in the action of two inotropic agents with different toxicity

(2011) Matteo Alemanni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

(2011) John R Teerlink et al.   LANCET

The Lost Decade of Nesiritide

(2011) Eric J. Topol   NEW ENGLAND JOURNAL OF MEDICINE

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Prognosis on Chronic Dobutamine or Milrinone Infusions for Stage D Heart Failure

(2009) Eiran Z. Gorodeski et al.   Circulation-Heart Failure

Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials

(2009) M. Metra et al.   EUROPEAN HEART JOURNAL

Oral levosimendan in patients with severe chronic heart failure-The PERSIST study

(2008) Markku S. Nieminen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Modulation of Sarcoplasmic Reticulum Function by PST2744 [Istaroxime; (E,Z)-3-((2-Aminoethoxy)imino) Androstane-6,17-dione Hydrochloride)] in a Pressure-Overload Heart Failure Model

(2008) M. Rocchetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent

(2008) Mihai Gheorghiade et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY