The crystal structure of MICU 2 provides insight into Ca 2+ binding and MICU 1‐ MICU 2 heterodimer formation

The conserved aspartate ring of MCU mediates MICU1 binding and regulation in the mitochondrial calcium uniporter complex

(2019) Charles B Phillips et al.   eLife

Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter

(2019) Yangfei Xing et al.   Cell Reports

Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism

(2019) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake

(2018) Maria Patron et al.   CELL DEATH AND DIFFERENTIATION

X-ray and cryo-EM structures of the mitochondrial calcium uniporter

(2018) Chao Fan et al.   NATURE

Cryo-EM structure of a fungal mitochondrial calcium uniporter

(2018) Nam X. Nguyen et al.   NATURE

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters

(2018) Rozbeh Baradaran et al.   NATURE

MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+

(2018) Kimberli J. Kamer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

(2018) Melanie Paillard et al.   MOLECULAR CELL

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

(2017) Alexander G. Bick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic control of the mitochondrial calcium uniporter complex

(2017) Chen-Wei Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICU2 Restricts Spatial Crosstalk between InsP 3 R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

(2017) Riley Payne et al.   Cell Reports

Functional roles of MICU1 and MICU2 in mitochondrial Ca 2+ uptake

(2016) Jessica Matesanz-Isabel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca 2+ Uptake Machinery of Skeletal Muscle

(2016) Denis Vecellio Reane et al.   MOLECULAR CELL

Architecture of the mitochondrial calcium uniporter

(2016) Kirill Oxenoid et al.   NATURE

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex

(2016) Ming-Feng Tsai et al.   eLife

Expression and preliminary characterization of human MICU2

(2016) Dan Li et al.   Biology Open

The Ca2+-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca2+ Uptake

(2015) Carmelina Petrungaro et al.   Cell Metabolism

Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake

(2014) L. Wang et al.   EMBO JOURNAL

The gatekeepers of mitochondrial calcium influx: MICU1 and MICU2

(2014) M. Ahuja et al.   EMBO REPORTS

MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter

(2014) K. J. Kamer et al.   EMBO REPORTS

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

MICU1 Controls Both the Threshold and Cooperative Activation of the Mitochondrial Ca2+ Uniporter

(2013) György Csordás et al.   Cell Metabolism

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

(2013) Anna Raffaello et al.   EMBO JOURNAL

MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling

(2013) Molly Plovanich et al.   PLoS One

EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex

(2013) Y. Sancak et al.   SCIENCE

MCU encodes the pore conducting mitochondrial calcium currents

(2013) Dipayan Chaudhuri et al.   eLife

X-ray Structures of Magnesium and Manganese Complexes with the N-Terminal Domain of Calmodulin: Insights into the Mechanism and Specificity of Metal Ion Binding to an EF-Hand

(2012) F. Timur Senguen et al.   BIOCHEMISTRY

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

(2012) Karthik Mallilankaraman et al.   CELL

Evolutionary Diversity of the Mitochondrial Calcium Uniporter

(2012) A. G. Bick et al.   SCIENCE

Insights into modulation of calcium signaling by magnesium in calmodulin, troponin C and related EF-hand proteins

(2011) Zenon Grabarek   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

After half a century mitochondrial calcium in- and efflux machineries reveal themselves

(2011) Ilaria Drago et al.   EMBO JOURNAL

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Calcium uptake mechanisms of mitochondria

(2010) Jaime Santo-Domingo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake

(2010) Fabiana Perocchi et al.   NATURE