Article
Infectious Diseases
Gregoire Saltiel, Vanina Meyssonnier, Younes Kerroumi, Beate Heym, Olivier Lidove, Simon Marmor, Valerie Zeller
Summary: This study found that rifampicin combination therapy did not show significant advantage for patients undergoing exchange arthroplasty for chronic Ca-PJIs.
Article
Microbiology
Llanos Salar-Vidal, Yvonne Achermann, John-Jairo Aguilera-Correa, Anja Poehlein, Jaime Esteban, Holger Bruggemann
Summary: Cutibacterium acnes is a common cause of prosthetic joint infections, with different phylotypes associated with different clinical conditions and normal skin. The study suggests that type IB strains have the potential to cause infection relapse, especially in hip PJIs. Furthermore, strains belonging to the same SLST type can differ in their accessory genome in different geographic locations, indicating microevolution.
Review
Infectious Diseases
Ozlem Aydin, Pinar Ergen, Burak Ozturan, Korhan Ozkan, Ferhat Arslan, Haluk Vahaboglu
Summary: This study conducted a meta-analysis on the efficacy of rifampin-accompanied antibiotic regimens in treating prosthetic joint infections, finding that rifampin supplementation was more effective in Streptococcus infections but not recommended for Staphylococcus infections.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Orthopedics
Michael M. Valenzuela, Benjamin J. Averkamp, Susan M. Odum, Taylor M. Rowe, Thomas K. Fehring
Summary: Open wound management may lead to conversion from a monomicrobial to a polymicrobial prosthetic joint infection, with a conversion rate of 34%. Prudent use of open wound management is necessary.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Infectious Diseases
M. Tonnelier, A. Bouras, C. Joseph, Y. El Samad, B. Brunschweiler, J. -L. Schmit, C. Mabille, J-P Lanoix
Summary: Prosthetic joint infections (PJI) are a major cause of morbidity and mortality worldwide. This study found that Rifampicin dose did not impact infection outcomes in PJI patients infected with Rifampicin-sensitive Staphylococcus species.
BMC INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Christos Koutserimpas, Ifigeneia Chamakioti, Stylianos Zervakis, Konstantinos Raptis, Kalliopi Alpantaki, Diamantis P. Kofteridis, Georgia Vrioni, George Samonis
Summary: Non-Candida fungal prosthetic joint infections pose a clinical challenge that requires a multidisciplinary approach. The combination of two-stage revision arthroplasty and prolonged antifungal treatment has been shown to be the standard of care in the reviewed cases.
Review
Infectious Diseases
Benjamin Le Vavasseur, Valerie Zeller
Summary: Prosthetic joint infection (PJI) is a severe complication after arthroplasty and its treatment involves a combination of surgical intervention and prolonged high-dose antibiotic therapy. The choice and quality of surgical procedures, microbiological diagnosis, and antibiotic therapy are crucial for the effectiveness of PJI management.
Article
Orthopedics
Azeem Tariq Malik, Jesse Morris, Julie Y. Bishop, Andrew S. Neviaser, Safdar N. Khan, Gregory L. Cvetanovich
Summary: Utilizing a national all-payer claims dataset, this study found that undergoing a prior shoulder arthroscopy before shoulder arthroplasty was associated with a higher risk of prosthetic joint infection, especially for those who had arthroscopy within 3 months before arthroplasty.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Review
Infectious Diseases
Javier Cobo, Rosa Escudero-Sanchez
Summary: The treatment of prosthetic joint infections (PJIs) is a complex matter that requires integration of surgical, microbiological, and pharmacological aspects, while also taking into consideration each patient's individual context. In some cases, curative treatment may not be possible, leading to the importance of long-term antibiotic administration to suppress the infection.
Article
Medicine, General & Internal
Martin H. Thornhill, Annabel Crum, Saleema Rex, Tony Stone, Richard Campbell, Mike Bradburn, Veronica Fibisan, Peter B. Lockhart, Bryan Springer, Larry M. Baddour, Jon Nicholl
Summary: This study investigated the temporal association between invasive dental procedures (IDP) and late prosthetic joint infection (LPJI) in England, where antibiotic prophylaxis has never been recommended for LPJI prevention, and found no significant association between IDP and subsequent LPJI, suggesting that administering antibiotic prophylaxis before IDP in patients with prosthetic joints may not be necessary.
Review
Medicine, General & Internal
Maria Eugenia Portillo, Ignacio Sancho
Summary: The article discusses the use of non-culture techniques in the diagnosis of prosthetic joint infections (PJI). Nucleic acid amplification and sequencing methods are described as useful tools for detecting and identifying pathogens. The new technologies have shown promise in improving the etiological diagnosis of PJI, but rigorous protocols are necessary to avoid contamination.
Article
Infectious Diseases
Amber C. Streifel, Cara D. Varley, YoungYoon Ham, Monica K. Sikka, James S. Lewis
Summary: Corynebacterium striatum, historically regarded as a contaminant, has been found to be associated with human infections, particularly in prosthetic joint infections. Vancomycin or linezolid is the most appropriate first-line therapy based on susceptibility patterns. Daptomycin treatment should be avoided due to the risk of development of high-level resistance and clinical failure.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Katharina Kusejko, Alvaro Aunon, Bernhard Jost, Benito Natividad, Carol Strahm, Christine Thurnheer, Daniel Pablo-Marcos, Dorsaf Slama, Giulia Scanferla, Ilker Uckay, Isabelle Waldmann, Jaime Esteban, Jaime Lora-Tamayo, Martin Clauss, Marta Fernandez-Sampedro, Marjan Wouthuyzen-Bakker, Matteo Carlo Ferrari, Natalie Gassmann, Parham Sendi, Philipp Jent, Philippe C. Morand, Prakhar Vijayvargiya, Rihard Trebse, Robin Patel, Roger D. Kouyos, Stephane Corvec, Tobias Siegfried Kramer, Vincent A. Stadelmann, Yvonne Achermann
Summary: Based on a multicenter retrospective study, the combination treatment of rifampin does not show marked superiority in Cutibacterium PJI, but may have a beneficial effect for some patients. Further dedicated prospective multicenter studies are needed to confirm these findings.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Luis Buzon-Martin, Ines Zollner-Schwetz, Selma Tobudic, Emilia Cercenado, Jaime Lora-Tamayo
Summary: Dalbavancin (DAL) is a lipoglycopeptide with bactericidal activity against a wide range of Gram-positive microorganisms, with unique pharmacokinetic properties and good diffusion in bone tissue. It is commonly used off-label in the treatment of bone and joint infections, including prosthetic joint infections (PJI).
Article
Infectious Diseases
Llanos Salar-Vidal, John Jairo Aguilera-Correa, Holger Bruggemann, Yvonne Achermann, Jaime Esteban
Summary: This study characterized Cutibacterium acnes strains isolated from prosthetic joint infections (PJIs) and evaluated their biofilm formation ability and antibiotic susceptibility. The results showed that C. acnes strains can produce biofilms and are susceptible to commonly used antibiotics, with rifampin being the most effective in eradicating biofilm-embedded strains.
Article
Orthopedics
Nathalie Pruijn, Floor M. van Diek, Jacques F. Meis, Nienke M. Kosse, Oscar Dorrestijn
Summary: The study found that the incidence of C. acnes infections was around 42% in patients with and without artificial material after shoulder surgery. Risk factors identified were age and BMI. Low-grade C. acnes infections should be considered in patients with unexplained persistent complaints following shoulder surgery.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Infectious Diseases
Anouk M. E. Jacobs, Petra J. C. Heesterbeek, Frans A. T. Bovendeert, Saskia Susan, Jacques F. Meis, Jon H. M. Goosen
Summary: The study evaluated the diagnostic accuracy of an automated mPCR of synovial fluid in unsuspected knee and hip revisions. In knee revisions, mPCR showed high specificity and NPV, while in hip revisions, it had lower sensitivity but higher specificity and NPV.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ashutosh Singh, Prerna Singh, Jacques F. Meis, Anuradha Chowdhary
Summary: Olorofim demonstrates potent in vitro activity against drug-resistant dermatophytes and opportunistic moulds, with exceptions in Alternaria alternata. When compared to other systemic antifungal drugs, Olorofim exhibits lower activity against Penicillium and Talaromyces species. Particularly, Olorofim shows strong activity against Trichophyton isolates, including those resistant to terbinafine and azoles.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Dermatology
Athanasios Chatzimoschou, Athina Giampani, Jacques F. Meis, Emmanuel Roilides
Summary: Candida auris exhibits higher MICs for fluconazole and relatively low MICs for itraconazole, posaconazole, and voriconazole. Echinocandins and liposomal amphotericin B also show lower activity against C auris biofilms compared to deoxycholate amphotericin B.
Article
Dermatology
Alireza Abdolrasouli, Malick M. Gibani, Theun de Groot, Andrew M. Borman, Peter Hoffman, Berge S. Azadian, Nabeela Mughal, Luke S. P. Moore, Elizabeth M. Johnson, Jacques F. Meis
Summary: This study investigated a pseudo-outbreak of Rhinocladiella similis in a bronchoscopy unit of a tertiary care teaching hospital in London. The potential source of contamination was determined to be a bronchoscope, but no infections were found in patients after the outbreak. The study emphasizes the importance of prolonged fungal culture and species-level identification in bronchoscopy samples.
Article
Microbiology
Anamika Yadav, Anubhav Singh, Yue Wang, Merlijn H. van Haren, Ashutosh Singh, Theun de Groot, Jacques F. Meis, Jianping Xu, Anuradha Chowdhary
Summary: The study revealed significant genetic and ecological diversities of Candida auris in healthcare settings, with 37.5% of patients with chronic respiratory diseases and 10% of fomite samples testing positive for the pathogen. Analysis showed multiple strains of C. auris infecting different body sites of patients and fomites.
Article
Dermatology
Joao Nobrega de Almeida, Igor B. Brandao, Elaine C. Francisco, Silvio Luis R. de Almeida, Patricia de Oliveira Dias, Felicidade M. Pereira, Fabio Santos Ferreira, Thaisse Souza de Andrade, Magda M. de Miranda Costa, Regiane T. de Souza Jordao, Jacques F. Meis, Arnaldo L. Colombo
Summary: This study described the first outbreak of Candida auris in Brazil, highlighting the potential transmission on patients and inanimate surfaces, as well as the antifungal susceptibility and genotyping results. The contaminated axillary monitoring thermometers were identified as an independent risk factor for C. auris colonization, and C. auris-related fungemia showed a high mortality rate.
Article
Dermatology
Fatemeh Ahangarkani, Macit Ilkit, Narges Vaseghi, Nina Zahedi, Kamiar Zomorodian, Sadegh Khodavaisy, Mohammad Hosein Afsarian, Kiana Abbasi, Theun de Groot, Jacques F. Meis, Hamid Badali
Summary: The study evaluated the species distribution, genetic diversity, and antifungal susceptibility profiles of Trichosporon isolates in Iran. The results showed distinct geographical differences in infections caused by Trichosporon species, with different species demonstrating varying susceptibility to antifungal drugs.
Review
Environmental Sciences
Vania Aparecida Vicente, Bruno Paulo Rodrigues Lustosa, Maria Eduarda Grisolia, Caroline Pavini Beato, Eduardo Balsanelli, Viviane de Souza Gubert Fruet, Meri Bordignon Nogueira, Sonia Maria Raboni, Katherine Athayde Teixeira Carvalho, Izadora Cervelin Flor, Morgana Ferreira Voidaleski, Ramiro Goncalves Etchepare, Jacques F. Meis, Vanete Thomaz Soccol, Emanuel Maltempi Souza
Summary: This study aimed to detect the presence of SARS-CoV-2 from inert surface samples in public health settings and found that the frequency of environmental contamination was higher in primary care units. Detection of SARS-CoV-2 RNA on surfaces in public health settings indicates widespread environmental contamination, highlighting the importance of intensifying disinfection measures for controlling community COVID-19 dissemination.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Elena De Carolis, Federica Marchionni, Marilisa La Rosa, Jacques F. Meis, Anuradha Chowdhary, Brunella Posteraro, Maurizio Sanguinetti
Summary: The present study aimed to implement MALDI-TOF mass spectrometry for species-level identification of C. auris isolates and develop a fast resistance detection assay. The MS-based assay showed potential for rapid diagnosis and appropriate treatment of patients with C. auris infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Joerg Steinmann, Thomas Schrauzer, Lisa Kirchhoff, Jacques F. Meis, Peter-Michael Rath
Summary: Candida auris poses a global fungal public health threat, with two cases reported in Germany showing multidrug resistance. Isolating patients and implementing contact precautions can effectively prevent nosocomial transmission of this emerging, multidrug-resistant pathogen.
Article
Dermatology
Mohammad Javad Najafzadeh, Somayeh Dolatabadi, Vania Aparecida Vicente, Gerrit Sybren de Hoog, Jacques F. Meis
Summary: This study investigated the in vitro activities of eight antifungal drugs against 126 clinical and environmental isolates of Exophiala species, revealing that posaconazole, itraconazole, and micafungin showed the best overall activity, while fluconazole was not considered an effective treatment choice. No significant difference was found in antifungal drug activities between different species of Exophiala, highlighting the importance of antifungal susceptibility data for managing this occasionally fatal infection.
Article
Dermatology
Shivaprakash M. Rudramurthy, Martin Hoenigl, Jacques F. Meis, Oliver A. Cornely, Valliappan Muthu, Jean Pierre Gangneux, John Perfect, Arunaloke Chakrabarti
Summary: Globally, the incidence of COVID-19-associated mucormycosis (CAM) is rising, with a significant surge in India. The need to address misconceptions in managing and treating this infection is crucial, with a focus on early suspicion, diagnosis confirmation, glycemic control, surgical debridement, and antifungal therapy. Limited availability of amphotericin B formulations during the epidemic has led to discussions on alternative antifungal therapies.
Meeting Abstract
Surgery
Osama Gheith, Torki Alotaibi, Khaled Alobiad, Prasad Nair, Sohair Zeineldein, Tarek Mahmoud, Medhat A. Halim, Hasaneen Aboatya, Mohamed Balaha, Khaled Atya, Ayman Maher Nagib, Abdullah Alhatmi, Amal Sadon, Jacques Meis, Mohamed Zahab
TRANSPLANT INTERNATIONAL
(2021)
Article
Immunology
Jon Salmanton-Garcia, Rosanne Sprute, Jannik Stemler, Michele Bartoletti, Damien Dupont, Maricela Valerio, Carolina Garcia-Vidal, Iker Falces-Romero, Marina Machado, Sofia de la Villa, Maria Schroeder, Irma Hoyo, Frank Hanses, Kennio Ferreira-Paim, Daniele Roberto Giacobbe, Jacques F. Meis, Jean-Pierre Gangneux, Azucena Rodriguez-Guardado, Spinello Antinori, Ertan Sal, Xhorxha Malaj, Danila Seidel, Oliver A. Cornely, Philipp Koehler
Summary: This study found that most patients with coronavirus disease-associated pulmonary aspergillosis (CAPA) are diagnosed shortly after admission, with the majority being treated in the ICU. Azole-resistant strains of Aspergillus fumigatus were common in patients, and voriconazole was the main treatment choice. The overall mortality rate was approximately 52.2%, with about one third of deaths attributed to CAPA.
EMERGING INFECTIOUS DISEASES
(2021)
