Article
Infectious Diseases
Karin Veerman, Jon Goosen, Karin Spijkers, Nynke Jager, Petra Heesterbeek, Denise Telgt
Summary: This study aimed to obtain detailed information on patient-reported adverse drug events (ADEs), dynamics of haematopoiesis, and reasons for early discontinuation of linezolid when used for a maximum duration of 12 weeks in the treatment of bone and joint infections. The findings suggest that linezolid could be considered as an alternative option for the treatment of bone and joint infections, with a high likelihood of successful completion of therapy and a low risk of serious ADEs after the first 28 days of treatment.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Pauline Thill, Olivier Robineau, Gabrielle Roosen, Pierre Patoz, Benoit Gachet, Barthelemy Lafon-Desmurs, Macha Tetart, Safia Nadji, Eric Senneville, Nicolas Blondiaux
Summary: This study compared the effectiveness of rifabutin and rifampicin in treating staphylococcal infections. The results showed that rifabutin was more effective in eradicating biofilms and had stronger bactericidal effects against clinical strains of staphylococci obtained from infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Microbiology
Laszlo Orosz, Gyorgy Lengyel, Klara Makai, Katalin Burian
Summary: A retrospective study at the University of Szeged in Hungary revealed an increase in rifampicin resistance among Corynebacterium striatum. The use of Rifadin to treat concomitant Staphylococcus aureus infections during the COVID-19 pandemic may have contributed to this decline in sensitivity. Fourier-transform infrared spectroscopy with the IR Biotyper revealed a close relationship among the rifampicin-resistant C. striatum strains, supporting this hypothesis. The IR Biotyper proved to be a modern and efficient method for antimicrobial stewardship programs.
Article
Gastroenterology & Hepatology
Mingxia Shi, Li Sheng, Min Lian, Qi Miao, Qixia Wang, Xiao Xiao, Xiong Ma
Summary: Rifampicin could be a promising option for most PHSF patients, especially those with UGT1A1 deficiency. In this study, 14 out of 16 PHSF patients who received rifampicin treatment showed more than 20% improvement in TBIL levels after 4 weeks, with all 14 eventually returning to normal TBIL levels after 6-12 weeks.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Letter
Microbiology
Lisiane da Luz Rocha Balzan, Adriana Medianeira Rossato, Cezar Vinicius Wurdig Riche, Vlademir Vicente Cantarelli, Pedro Alves D'Azevedo, Aline Valerio de Lima, Beatriz Rodrigues, Ivan Leonardo Avelino Franca e Silva, Cicero Armidio Gomes Dias, Jorge Luiz Mello Sampaio
Summary: In 2015, two new species related to Staphylococcus aureus were proposed. We report the isolation of five strains of the newly identified species, Staphylococcus argenteus, from human cases of bacteremia and skin and soft tissue infections. This is the first documentation of S. argenteus causing community-acquired and hospital-acquired infections in South America.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Seok Jun Mun, Si-Ho Kim, Kyungmin Huh, Sun Young Cho, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck
Summary: This study found that in patients with uncomplicated S. aureus CRBSI, the risk of treatment failure may be more influenced by factors such as liver cirrhosis and other prostheses, rather than the implementation of echocardiography. Routine echocardiography might not be necessary given the low rates of adverse outcomes observed, and could be considered on an individual basis.
Article
Multidisciplinary Sciences
Tigran Makunts, Keith Burkhart, Ruben Abagyan, Peter Lee
Summary: Biologics targeting immune checkpoint proteins can enhance the immune response against cancer cells, but also have the risk of causing immune related adverse events (irAEs). This study found that patients receiving pembrolizumab treatment had an 80% increased risk of developing irAEs when also having an infection.
Article
Oncology
Dan Cui, Xiaomeng Hu, Li Shi, Dongchang Wang, Gang Chen
Summary: This retrospective study evaluated the safety of linezolid (LZD) in the treatment of patients with rifampicin-resistant tuberculosis. The results showed that peripheral neuritis and hemochromatosis were the most common adverse effects observed. Female patients, history of underlying disease, LZD use time, LZD dosage, and age were identified as risk factors in the LZD treatment. Close monitoring of bone marrow suppression and neuropathy is recommended during medication.
JOURNAL OF CHEMOTHERAPY
(2023)
Review
Infectious Diseases
Narayan Pant, Damon P. Eisen
Summary: Staphylococcus aureus biofilms play a significant role in chronic infections by protecting bacteria from antimicrobials and the immune system. The complexity of biofilm biology, particularly in S. aureus, highlights the need for novel treatment approaches targeting vulnerable genetic and biochemical processes. Successful treatment strategies in animal models provide potential insights for the prevention and eradication of biofilm-related S. aureus infections.
Article
Infectious Diseases
T. Goulenok, J. Seurat, A. de La Selle, V. Jullien, V. Leflon-Guibout, N. Grall, F. X. Lescure, R. Lepeule, J. Bertrand, B. Fantin, C. Burdet, A. Lefort
Summary: The study aimed to investigate the pharmacokinetic/pharmacodynamic (PK/PD) interaction between rifampicin and clindamycin in the treatment of staphylococcal osteoarticular infection (SOAI). Results showed that co-administration of rifampicin significantly increased clindamycin clearance and decreased the probability of reaching PK/PD targets. These findings suggest that the use of rifampicin in combination with clindamycin may result in clinical failure, even for fully susceptible strains.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biology
Junlan Liu, Zhen Shen, Jin Tang, Qian Huang, Ying Jian, Yao Liu, Yanan Wang, Xiaowei Ma, Qian Liu, Lei He, Min Li
Summary: The study investigates the role of small colony variants (SCVs) in catheter infection, revealing mutations in metabolic processes and disturbances in biosynthetic pathways in stable SCV. SCV demonstrates higher biofilm-forming ability due to glycine shortage, excess pyruvic acid, and acetyl-CoA overflow. Despite decreased cell viability, SCV can facilitate biofilm formation and in vivo survival of normal counterparts.
COMMUNICATIONS BIOLOGY
(2021)
Article
Anesthesiology
Joshua Aviram, Gil M. Lewitus, Yelena Vysotski, Paula Berman, Anna Shapira, Shiri Procaccia, David Meiri
Summary: Studies have shown that women are more susceptible to adverse effects from conventional drugs. This study aimed to investigate the differences of medical cannabis-related adverse effects between women and men in patients with chronic noncancer pain. The results showed that women reported more medical cannabis-related adverse effects, possibly due to both the inherent sex effect and the consumption of specific phytocannabinoid compositions.
Article
Pharmacology & Pharmacy
Keli Wang, Juefang Ding, Xianjing Li, Wenjing Guo, Xingyu Zhu, Yue Su, Luning Sun, Huan Zhou, Li Ding
Summary: This study investigated the drug-drug interactions of Youkenafil. The results showed that Youkenafil was mainly metabolized through CYP3A4/5. Itraconazole increased the concentration of Youkenafil and its metabolite M1, while rifampicin reduced the concentration of Youkenafil. Therefore, co-administration of Youkenafil with potent inhibitors or inducers of CYP3A4/5 should be avoided or carefully monitored.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Microbiology
Seongman Bae, Eun Sil Kim, Hee Seung Kim, Eunmi Yang, Hyemin Chung, Yun Woo Lee, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sung-Han Kim, Sang-Ho Choi, Sang-Oh Lee, Yang Soo Kim
Summary: This study used competing risk analysis to identify risk factors for 90-day recurrence in patients with Staphylococcus aureus bacteremia. Results showed that the presence of a vascular graft, nasal MRSA carriage, methicillin resistance, and rifampicin resistance were significantly associated with recurrence risk.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Anne Coste, Melanie Poinot, Sophie Panaget, Benedicte Albert, Adrien Kaladji, Herve Le Bars, Nasr Bahaa, Badra Ali, Caroline Piau, Vincent Cattoir, Claire de Moreuil, Matthieu Revest, Rozenn Le Berre
Summary: This study included 112 patients with possible (n = 26), probable (n = 22), and proven (n = 64) PVGI, and found a treatment failure rate of 27.5% in patients with PVGI. Total removal of the infected graft and rifampicin administration were associated with better outcomes.
Article
Infectious Diseases
C. Mabille, Y. El Samad, C. Joseph, B. Brunschweiler, V Goeb, F. Grados, J. P. Lanoix
Summary: This study compared the effectiveness of medical and surgical approaches for native joint septic arthritis. The results showed no significant difference in failure rates between the two methods, but medical treatment resulted in a shorter hospital stay and fewer sequelae.
INFECTIOUS DISEASES NOW
(2021)
Article
Pharmacology & Pharmacy
Benjamin Batteux, Sandra Bodeau, Valerie Gras-Champel, Sophie Liabeuf, Jean-Philippe Lanoix, Jean-Luc Schmit, Claire Andrejak, Yoann Zerbib, Guillaume Haye, Kamel Masmoudi, Anne-Sophie Lemaire-Hurtel, Youssef Bennis
Summary: A study on 65 COVID-19 patients indicated that although lopinavir/ritonavir may cause adverse events, they are not directly related to plasma concentrations. Further research is needed to determine the value of therapeutic drug monitoring in patients treated with lopinavir/ritonavir for COVID-19.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Abdallah Al-Salameh, Jean-Philippe Lanoix, Youssef Bennis, Claire Andrejak, Etienne Brochot, Guillaume Deschasse, Herve Dupont, Vincent Goeb, Maite Jaureguy, Sylvie Lion, Julien Maizel, Julien Moyet, Benoit Vaysse, Rachel Desailloud, Olivier Ganry, Jean-Luc Schmit, Jean-Daniel Lalau
Summary: This study compared clinical features and outcomes in hospitalized COVID-19 patients with and without diabetes, finding that diabetes was associated with a higher risk of ICU admission but not with a significant increase in mortality. Age was found to play a role in ICU admission and death. Further research on the relationship between COVID-19 severity and diabetes is needed.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Sophie Liabeuf, Julien Moragny, Youssef Bennis, Benjamin Batteux, Etienne Brochot, Jean Luc Schmit, Jean-Philippe Lanoix, Claire Andrejak, Olivier Ganry, Michel Slama, Julien Maizel, Yazine Mahjoub, Kamel Masmoudi, Valerie Gras-Champel
Summary: The study found that long-term use of RASIs may be associated with an increased risk of severe COVID-19 and poor outcomes, highlighting the need for formal proof through clinical trials to better understand this association.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Microbiology
Dalin Rifat, Si-Yang Li, Thomas Ioerger, Keshav Shah, Jean-Philippe Lanoix, Jin Lee, Ghader Bashiri, James Sacchettini, Eric Nuermberger
Summary: Pretomanid-resistant Mycobacterium tuberculosis mutants were selected in mouse models, with mutations mainly occurring in genes associated with nitroimidazole activation and resistance. Some mutants displayed hypersusceptibility to certain antibiotics and dyes found in culture media, indicating potential cross-resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Abdallah Al-Salameh, Jean-Philippe Lanoix, Youssef Bennis, Claire Andrejak, Etienne Brochot, Guillaume Deschasse, Herve Dupont, Vincent Goeb, Maite Jaureguy, Sylvie Lion, Julien Maizel, Julien Moyet, Benoit Vaysse, Rachel Desailloud, Olivier Ganry, Jean-Luc Schmit, Jean-Daniel Lalau
Summary: The study found that being overweight is associated with ICU admission among COVID-19 patients, but not with death. Obesity is associated with higher risk of ICU admission and death among COVID-19 patients.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Medicine, Research & Experimental
Andreea Rosca, Thibaut Balcaen, Jean-Philippe Lanoix, Audrey Michaud, Julien Moyet, Ingrid Marcq, Jean-Luc Schmit, Frederic Bloch, Guillaume Deschasse
Summary: Patients over 80 years old with COVID-19 who received antibiotics had higher mortality rates compared to those who did not, though the difference was not statistically significant. An increased leukocyte count and decreased oxygen saturation were identified as independent risk factors for mortality. Further research is encouraged to investigate the interest and efficacy of antibiotic therapy in COVID-19 cases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Infectious Diseases
Florence Ader, Nathan Peiffer-Smadja, Julien Poissy, Maude Bouscambert-Duchamp, Drifa Belhadi, Alpha Diallo, Christelle Delmas, Juliette Saillard, Aline Dechanet, Noemie Mercier, Axelle Dupont, Toni Alfaiate, Francois-Xavier Lescure, Francois Raffi, Francois Goehringer, Antoine Kimmoun, Stephane Jaureguiberry, Jean Reignier, Saad Nseir, Francois Danion, Raphael Clere-Jehl, Evin Bouiller, Jean-Christophe Navellou, Violaine Tolsma, Andre Cabie, Clement Dubost, Johan Courjon, Sylvie Leroy, Joy Mootien, Rostane Gaci, Bruno Mourvillier, Emmanuel Faure, Valerie Pourcher, Sebastien Gallien, Odile Launay, Karine Lacombe, Jean-Philippe Lanoix, Alain Makinson, Guillaume Martin-Blondel, Lila Bouadma, Elisabeth Botelho-Nevers, Amandine Gagneux-Brunon, Olivier Epaulard, Lionel Piroth, Florent Wallet, Jean-Christophe Richard, Jean Reuter, Therese Staub, Bruno Lina, Marion Noret, Claire Andrejak, Minh Patrick Le, Gilles Peytavin, Maya Hites, Dominique Costagliola, Yazdan Yazdanpanah, Charles Burdet, France Mentre
Summary: This study evaluated the clinical, virological, and safety outcomes of different treatment options in hospitalized COVID-19 patients, showing that lopinavir/ritonavir, lopinavir/ritonavir-IFN-beta-1a, and hydroxychloroquine did not improve the clinical status or SARS-CoV-2 clearance in respiratory tract specimens.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Geriatrics & Gerontology
J. Moyet, F. Helle, G. Bourdenet, C. Joseph, B. Gubler, G. Deschasse, I. Defouilloy, T. Slovenski, C. Francois, S. Liabeuf, J. L. Schmit, J. P. Lanoix, S. Castelain, Frederic Bloch, E. Brochot
Summary: Elderly residents of nursing homes and long-term care units maintain a dynamic change in neutralizing antibodies against SARS-CoV-2, with some showing increased antibody levels after vaccination, but a weaker antibody response for residents who were seronegative before vaccination.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Infectious Diseases
Adrien Chan Sui Ko, Alexandre Candellier, Marie Mercier, Cedric Joseph, Jean-Luc Schmit, Jean-Philippe Lanoix, Claire Andrejak
Summary: This study analyzed the risk factors associated with long COVID-19 in hospitalized patients and found that female sex, hypertension, and the number of initial symptoms were significantly associated with persistent symptoms.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Renaud Prevel, Annabelle Dupont, Sylvie Labrouche-Colomer, Geoffrey Garcia, Antoine Dewitte, Antoine Rauch, Julien Goutay, Morgan Caplan, Elsa Jozefowicz, Jean-Philippe Lanoix, Julien Poissy, Etienne Riviere, Arthur Orieux, Denis Malvy, Didier Gruson, Loic Garcon, Sophie Susen, Chloe James
Summary: The study found that elevated levels of NET markers in hospitalized COVID-19 patients are associated with death and pulmonary embolism (PE) occurrence. However, restricting the analysis to the most severe ARDS patients did not find a link between NET markers and PE occurrence.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Isabelle Bonnet, Elie Haddad, Lorenzo Guglielmetti, Pascale Bemer, Louis Bernard, Anne Bourgoin, Rachel Brault, Gaud Catho, Eric Caumes, Lelia Escaut, Eric Fourniols, Mathilde Frechet-Jachym, Alice Gaudart, Helene Guillot, Barthelemy Lafon-Desmurs, Jean-Philippe Lanoix, Philippe Lanotte, Adrien Lemaignen, Benedicte Lemaire, Nadine Lemaitre, Christophe Michau, Philippe Morand, Faiza Mougari, Dhiba Marigot-Outtandy, Solene Patrat-Delon, Thomas Perpoint, Caroline Piau, Valerie Pourcher, Virginie Zarrouk, Valerie Zeller, Nicolas Veziris, Stephane Jaureguiberry, Alexandra Aubry
Summary: This study evaluated the diagnosis, management, and outcomes of multidrug-resistant tuberculosis strains (MDR-OATB) causing osteoarticular infection in France. Among 23 reported MDR-OATB cases, 91% of patients successfully completed treatment. However, further research is needed to determine the optimal treatment for MDR-OATB.
Article
Medicine, General & Internal
Adrien Chan Sui Ko, Alexandre Candellier, Marie Mercier, Cedric Joseph, Hortense Carette, Damien Basille, Sylvie Lion-Daolio, Stephanie Devaux, Jean-Luc Schmit, Jean-Philippe Lanoix, Claire Andrejak
Summary: This study aimed to analyze whether corticosteroid use in the acute phase of COVID-19 may reduce the risk of persistent symptoms. The results showed that corticosteroid use had no impact on the presence or number of persistent symptoms in discharged patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Microbiology
Florence Dupont, Aurelien Aubry, Jean-Philippe Lanoix, Baptiste Demey
Summary: Cytomegalovirus-associated Gianotti-Crosti syndrome is a rare complication of cytomegalovirus infection that can lead to disruption of anticoagulant treatment and potentially fatal thromboembolic incidents. This article presents a unique case of this syndrome in an immunocompetent adult patient, which has not been reported in the literature before.
Article
Microbiology
Sandrine Castelain, Catherine Francois, Baptiste Demey, Aurelien Aubry, Jean-Philippe Lanoix, Gilles Duverlie, Jean-Luc Schmit, Etienne Brochot
Summary: Saliva sampling is of importance in the context of a second wave of SARS-CoV-2 transmission, but results from a study of samples collected from elderly residential homes showed a lower positive rate compared to nasopharyngeal samples. Swabbed saliva may not be an ideal sample for detection in this context.
NEW MICROBIOLOGICA
(2021)
