Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease

HOX transcript antisense RNA is elevated in gastric carcinogenesis and regulated by the NF-κB pathway

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Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility

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Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1–Enzalutamide Combination Treatment

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Values and Limitations of Targeting lncRNAs in Diabetic Nephropathy

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LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling

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De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis

(2018) Chunming Ding et al.   Nature Communications

Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway

(2018) Shan Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long noncoding RNA MALAT1 regulates renal tubular epithelial pyroptosis by modulated miR-23c targeting of ELAVL1 in diabetic nephropathy

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LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with β-catenin

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Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease

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LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

(2017) Quan Hong et al.   Cell Death & Disease

LincRNA-Gm4419 knockdown ameliorates NF-κB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy

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Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs

(2016) Marta Melé et al.   GENOME RESEARCH

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

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TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

An endoplasmic reticulum stress-regulated lncRNA hosting a microRNA megacluster induces early features of diabetic nephropathy

(2016) Mitsuo Kato et al.   Nature Communications

Comment on "Hotair Is Dispensable for Mouse Development"

(2016) Lingjie Li et al.   PLoS Genetics

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

(2016) Licia Selleri et al.   PLoS Genetics

Hotair Is Dispensible for Mouse Development

(2016) Ana Rita Amândio et al.   PLoS Genetics

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

(2015) Anna Motterle et al.   DIABETOLOGIA

The Histone Methyltransferase Enzyme Enhancer of Zeste Homolog 2 Protects against Podocyte Oxidative Stress and Renal Injury in Diabetes

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Diverse Phenotypes and Specific Transcription Patterns in Twenty Mouse Lines with Ablated LincRNAs

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Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease

(2015) Shunsaku Nakagawa et al.   PLoS One

The ways of action of long non-coding RNAs in cytoplasm and nucleus

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Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals

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RNA Binding of PRC2: Promiscuous or Well Ordered?

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Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

(2014) Helena M. Kok et al.   Nature Reviews Nephrology

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

(2013) Je-Hyun Yoon et al.   Nature Communications

Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression

(2013) Lingjie Li et al.   Cell Reports

The sequence, structure and evolutionary features of HOTAIR in mammals

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RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions

(2011) Ci Chu et al.   MOLECULAR CELL

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human

(2011) Patrick Schorderet et al.   PLoS Genetics

Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq

(2010) Jing Zhao et al.   MOLECULAR CELL

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype

(2010) Gaelle M. Lefevre et al.   PLoS Genetics

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA