Article
Chemistry, Multidisciplinary
Manoj K. Jaiswal, Abhishek Gupta, Mangal S. Yadav, Vinay K. Pandey, Vinod K. Tiwari
Summary: A novel organocatalyzed [3+2] cycloaddition reaction has been developed for the construction of 1,5-disubstituted triazolyl glycoconjugates. The reaction involves the use of Schreiner thiourea organocatalysts to activate nitroolefins through double hydrogen bonding. This metal-free and acid-free synthetic protocol is operationally simple, regioselective, and complements the classical RuAAC catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles. By using catalytic amounts of the Schreiner thiourea organocatalyst, a wide range of organic azides can react with nitroolefins to produce diverse 1,5-disubstituted 1,2,3-triazoles in good yields with excellent regioselectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuechao Zhu, Xian Zhang, Qidong You, Zhengyu Jiang
Summary: Click chemistry, particularly the firefly-sourced click reaction between cysteine and 2-cyanobenzothiazole, has gained significant attention due to its rapidity, simplicity, high selectivity, and unique ability to form nanoparticles. It has found successful applications in protein labeling, molecular imaging, drug discovery, and other fields, expanding its potential in biological systems.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hua-Feng He, Yuwan Wang, Chun Zou, Zheng Tu, Yongquan Xu, Junfeng Yin
Summary: A series of aryl cyclolactones bearing an exocyclized C=C bond were successfully constructed from aryl propargyl ether and o-iodibenzoic acid with moderate to good yields. The reaction showed excellent compatibility with diverse substituent groups and a concise mechanism was proposed based on substrate expansion and theoretical analysis.
Article
Chemistry, Multidisciplinary
Hua-Feng He, Yuwan Wang, Chun Zou, Zheng Tu, Yongquan Xu, Junfeng Yin
Summary: In this study, a series of aryl cyclolactones bearing an exocyclized C=C bond were successfully constructed using aryl propargyl ether and o-iodibenzoic acid as substrates. The reaction showed excellent compatibility and moderate to good yields. A concise mechanism was proposed based on substrate expansion and theoretical analysis.
Article
Chemistry, Multidisciplinary
Cecilia Garcia-Oliva, Alejandro Merchan, Almudena Perona, Pilar Hoyos, Angel Rumbero, Maria J. Hernaiz
Summary: Two green strategies, solvent free mechanochemistry and microwave irradiation using a recycable biosolvent, based on two activation pathways, for copper-catalyzed azide-alkyne cycloaddition reaction were reported. Glucuronic acid glycodendrimers were synthesized with good conversions (99%), with the microwave pathway being the ideal tool (90% yield in 90 min).
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Michaela Hovorkova, Jakub Cerveny, Ladislav Bumba, Helena Pelantova, Josef Cvacka, Vladimir Kren, Olivier Renaudet, David Goyard, Pavla Bojarova
Summary: A new type of glycoconjugate with low nanomolar affinity was developed to inhibit galectins of interest for biomedical research. The presentation of carbohydrate ligands on specific structural scaffolds was found to impact the affinity and selectivity to different galectins.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Loic Habert, Matthieu Daniel, Pascal Palmas, Eric Pasquinet
Summary: This study describes the synthesis of 5-hydrazino-3-nitro-1,2,4-triazole (HNT) from 5-bromo-3-nitro-1,2,4-triazole (BNT) in three steps. HNT demonstrates excellent thermal stability and powerful energetic properties. Various salts of HNT were synthesized to demonstrate its amphoteric nature. Compounds derived from HNT, particularly perchlorate 7 and fused triazolo[4,3-b]triazole 4, exhibit remarkable performance and potential as high-density and heat-resistant explosives.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Leona L. Rodrigues, Aaron S. Micallef, Michael C. Pfrunder, Vinh X. Truong, John C. McMurtrie, Tim R. Dargaville, Anja S. Goldmann, Florian Feist, Christopher Barner-Kowollik
Summary: A highly efficient ligation system based on visible light-induced rearrangement was introduced, generating a thiophenol for rapid thiol-Michael additions without the need for additives. The self-catalyzed ligation through pyridine mediated deprotonation of the photochemically generated thiophenol was described, leading to additive-free thiol-Michael reactions. The study explored various reaction conditions, solvents, and substrates, showcasing excellent end group fidelity in polymer modification.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Immunology
Giuseppe Stefanetti, Francesco Borriello, Barbara Richichi, Ivan Zanoni, Luigi Lay
Summary: Carbohydrates play a critical role in immunobiological processes and can be used as antigens or adjuvants in vaccines. However, adjuvants have shown limited ability to improve immune response to carbohydrate-based vaccines in humans. Aluminum salts remain the only authorized adjuvant for carbohydrate-based vaccines.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Katharina Baur, Dominik Heim, Astrid Beerlage, Anna S. Poerings, Bastian Kopp, Michael Medinger, Jan C. Dirks, Jakob R. Passweg, Andreas Holbro
Summary: Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are severe side effects of CAR T-cell therapy, and current treatment options include IL-1 and IL-6 blockade and steroids. However, the use of steroids is controversial due to potential damage to CAR T-cells. This study reports successful treatment of a CRS and ICANS patient refractory to IL-6 blockade and steroids using the tyrosine kinase inhibitor dasatinib, suggesting its potential as an alternative treatment option.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Xing-Wei Gu, Yan-Hua Zhao, Xiao-Feng Wu
Summary: Here, a novel methodology using aryl sulfonium salts as aryne precursors for [3 + 2] cycloaddition reactions with azides is described. The reaction, employing readily available arenes as feedstock, exhibits excellent atom economy, environmental friendliness, and high functional group tolerance. Furthermore, the outstanding performance in gram-scale reaction, deuterium labeling, and derivatization reactions suggests potential opportunities for large-scale production and other applications.
Article
Biochemistry & Molecular Biology
Naying Chu, Yitong Wang, Hao Jia, Jie Han, Xiaoyi Wang, Zhuang Hou
Summary: In this study, a series of new carbohydrate-based coumarin carbonic anhydrase IX inhibitors were designed and synthesized. These compounds showed better CA IX inhibitory activity than initial coumarin fragments. Compound 10a possessed the most potent CA IX inhibitory activity with high selectivity for CA I and CA II. These compounds also demonstrated anti-cancer effects and good stability. Furthermore, docking studies provided insights into the interactions between these compounds and the protein target CA IX.
Article
Multidisciplinary Sciences
Qiaochu Jiang, Wenjun Zhan, Xiaoyang Liu, Lin Bai, Manli Wang, Ying Xu, Gaolin Liang
Summary: The authors present an assembly-driven, regioselective metal-free azide-alkyne cycloaddition reaction with potential applications in biomedical contexts. In the absence of metal ions, supramolecular self-assembly in an aqueous solution is used to achieve excellent regioselectivity in the reaction, paving the way for more metal-free reactions in chemical biology.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Shanmugam Revathi, Aditya L. Shinde, Mulimani K. Rajashekhar, Debasish Mandal, Amit Ranjan Maity, Somenath Garai, Tapas Ghatak
Summary: A novel synthetic approach using innovative metal-free N-heterocyclic imino catalysts has been developed to efficiently synthesize regioselective 1,4-disubstituted 1,2,3-triazoles. Experimental observations have been supported by TD-DFT computational studies. This state-of-the-art metal-free approach serves as an alternative to CuAAC and shows promising potential in the field of synthesizing regioselective 1,4-triazoles.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Attilio Chiavegatti Neto, Kelly Cintra Soares, Maiara da Silva Santos, Tulio Jardini Aimola, Antonio Gilberto Ferreira, Guilherme A. M. Jardim, Claudio Francisco Tormena, Marcio Weber Paixao, Marco Antonio Barbosa Ferreira
Summary: Here, a fully detailed mechanistic study on the organocatalyzed metal-free click reactions for the synthesis of 1,2,3-triazoles is reported. The elementary steps, intermediates, and transition states of the reactions are investigated using DFT calculations and H-1 NMR monitoring experiments, providing detailed profiles for both reaction mechanisms. DIAS analysis is also employed to elucidate the regioselectivity in these reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Ummi Zulaiqha Hamid, Maw Shin Sim, Rhanye Mac Guad, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Ker Woon Choy, Ismail Muhamad Fareez, Srinivasa Reddy Bonam, Yuan Seng Wu
Summary: HOTTIP, a long non-coding RNA (lncRNA), plays a crucial regulatory role in GI cancer, affecting multiple aspects of cancer progression and chemoresistance, including cellular functions and molecular mechanisms. It also exhibits a higher diagnostic value compared to existing biomarkers, making it a potential novel therapeutic target and diagnostic biomarker in GI cancer treatment.
CURRENT MOLECULAR MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Niranjan G. Kotla, Srinivasa Reddy Bonam, Swetha Rasala, Jitendra Wankar, Raghvendra A. Bohara, Jagadeesh Bayry, Yury Rochev, Abhay Pandit
Summary: Hyaluronan, a naturally occurring biopolymer, has diverse biological effects and plays a crucial role in inflammation and cancer. This review discusses the sources, properties, and potential applications of hyaluronan in therapeutic systems and cancer targeting delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Medicinal
Nurul Amirah Mohd Zaid, Mahendran Sekar, Srinivasa Reddy Bonam, Siew Hua Gan, Pei Teng Lum, M. Yasmin Begum, Nur Najihah Izzati Mat Rani, Jaishree Vaijanathappa, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria
Summary: This review provides a brief overview of the effects and mechanisms of ten selected natural products in the treatment of inflammatory, neoplastic, and infectious skin disorders. Most of the natural products show anti-inflammatory, antioxidant, antimicrobial, and anticancer effects. The findings suggest that natural products could be a cost-effective, well-tolerated, and safe treatment option for skin diseases.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Biology
Pei Teng Lum, Mahendran Sekar, Siew Hua Gan, Srikanth Jeyabalan, Srinivasa Reddy Bonam, Nur Najihah Izzati Mat Rani, Ku-Marina Ku-Mahdzir, Lay Jing Seow, Yuan Seng Wu, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria
Summary: Mangiferin, a natural product, exhibits therapeutic benefits against various kidney disorders in animal models through antioxidant responses and regulation of physiological functions. It is considered a safe reno-protective molecule that protects the kidneys by inhibiting inflammation and oxidative stress. Further clinical trials are needed to confirm its potential as a therapeutic agent for kidney disorders in humans.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Srinivasa Reddy Bonam, Camille Chauvin, Laurine Levillayer, Mano Joseph Mathew, Anavaj Sakuntabhai, Jagadeesh Bayry
Summary: This study reports that SARS-CoV-2 induces cytokine responses, particularly IL-13, in both resting and IL-3 primed basophils. However, the expression of surface markers associated with basophil activation and PD-L1 expression on basophils are not affected by SARS-CoV-2. The results suggest that basophil cytokine responses to SARS-CoV-2 might help reduce inflammation and promote antibody responses to the virus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Talasila Bhanu Teja, Mahendran Sekar, Talasila Pallavi, Sivamma Mettu, T. E. Gopalakrishna Murthy, Nur Najihah Izzati Mat Rani, Pallaval Veera Bramhachari, Srinivasa Reddy Bonam
Summary: Artificial Neural Networks (ANN) are widely used in the pharmaceutical industry to mimic the brain's functioning and solve various problems by analyzing and transforming information.
JOURNAL OF YOUNG PHARMACISTS
(2022)
Article
Cell Biology
Srinivasa Reddy Bonam, Camille Chauvin, Mano J. Mathew, Jagadeesh Bayry
Summary: This study identifies IFN-gamma as one of the factors that induce PD-L1 expression in human basophils and demonstrates the importance of IL-3 priming in IFN-gamma-induced PD-L1 expression.
Editorial Material
Microbiology
Srinivasa R. Bonam, Haitao Hu, Jagadeesh Bayry
Summary: Severe COVID-19 patients show dysregulated expression of checkpoint molecules PD-1 and PD-L1, indicating that these molecules could be considered as prognostic markers and therapeutic targets in severe cases of COVID-19.
FUTURE MICROBIOLOGY
(2022)
Article
Cell Biology
Renee L. Hajnik, Jessica A. Plante, Yuejin Liang, Mohamad-Gabriel Alameh, Jinyi Tang, Srinivasa Reddy Bonam, Chaojie Zhong, Awadalkareem Adam, Dionna Scharton, Grace H. Rafael, Yang Liu, Nicholas C. Hazell, Jiaren Sun, Lynn Soong, Pei-Yong Shi, Tian Wang, David H. Walker, Jie Sun, Drew Weissman, Scott C. Weaver, Kenneth S. Plante, Haitao Hu
Summary: This study reports a nucleoside-modified mRNA vaccine expressing the viral nucleoprotein, which shows modest control of SARS-CoV-2 when administered alone. However, combining this vaccine with a clinically proven mRNA vaccine expressing the spike protein induces robust protection against both Delta and Omicron variants.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Srinivasa Reddy Bonam, Peter Paul Platenburg, Jagadeesh Bayry
Summary: In this study, the immunopotentiating mechanism of an oil-in-water emulsion-based vaccine adjuvant called LiteVax Adjuvant (LVA) was analyzed. The researchers investigated the effect of LVA and its components on the function of dendritic cells (DC), which play a crucial role in the immune response. They found that the component CMS significantly enhanced DC activation markers, cytokine secretion, and CD4(+) T cell responses. This study identified the unique role of CMS in LVA and proposed that LVA acts as a delivery system while CMS acts as an immunostimulatory agent.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Medicinal
Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad
Summary: There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Among these members, TM4SF1, TM4SF4, and TM4SF5 play crucial roles in cancer angiogenesis, progression, and chemoresistance. Targeting these TM4SF members has emerged as a promising strategy for cancer therapy.
Editorial Material
Immunology
Nitin K. Saksena, Pedro A. Reche, Srinivasa Reddy Bonam, Nicasio Mancini
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Immunology
Sruthi Vijaya Retnakumar, Srinivasa Reddy Bonam, Haitao Hu, Jagadeesh Bayry
Review
Immunology
K. Swetha, Niranjan G. Kotla, Lakshmi Tunki, Arya Jayaraj, Suresh K. Bhargava, Haitao Hu, Srinivasa Reddy Bonam, Rajendra Kurapati
Summary: Lipid nanoparticles (LNPs) are an advanced technology for efficient in vivo delivery of exogenous mRNA, especially for COVID-19 vaccines. LNPs consist of four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG). This review presents recent advances and insights in LNPs design, composition, and properties, with a focus on COVID-19 vaccine development. The role of ionizable lipids in mRNA vaccines and the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy are discussed.
Article
Biochemistry & Molecular Biology
Chetan Ram, Shobhit Gairola, Shobhit Verma, Madhav Nilakanth Mugale, Srinivasa Reddy Bonam, Upadhyayula Suryanarayana Murty, Bidya Dhar Sahu
Summary: Nephropathy, the most common microvascular disorder in diabetes, is aggravated by oxidative stress and inflammatory response caused by persistent hyperglycemia. This study investigated the effects of biochanin A on inflammation, NLRP3 inflammasome activation, oxidative stress, and fibrosis in diabetic kidneys. The results showed that biochanin A improved renal function, reduced histological changes, and suppressed NF-kappa B/NLRP3 axis in diabetic rats. In vitro studies also demonstrated that biochanin A reduced oxidative stress and apoptosis in high-glucose-induced renal tubular epithelial cells. Additionally, it inhibited the upregulation of NLRP3 and its associated proteins and blunted TGF-beta/Smad signaling and collagen production. These findings suggest the potential role of biochanin A in attenuating diabetic nephropathy.