Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

B-cell targeting in chronic graft-versus-host disease

(2018) Robert Zeiser et al.   BLOOD

Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease

(2018) Supinya Iamsawat et al.   JOURNAL OF IMMUNOLOGY

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lack of p53 Augments Antitumor Functions in Cytolytic T Cells

(2016) Anirban Banerjee et al.   CANCER RESEARCH

Vitamin C Facilitates Demethylation of theFoxp3Enhancer in a Tet-Dependent Manner

(2016) Varun Sasidharan Nair et al.   JOURNAL OF IMMUNOLOGY

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

SIRT1 deacetylates RORγt and enhances Th17 cell generation

(2015) Hyung W. Lim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

(2015) Jilu Zhang et al.   Science Translational Medicine

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

(2014) D. Sasca et al.   BLOOD

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

(2014) R. Flynn et al.   BLOOD

Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4+ T Cell Responses

(2014) Masashi Watanabe et al.   IMMUNITY

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transcriptional regulation of follicular T-helper (Tfh) cells

(2013) Xindong Liu et al.   IMMUNOLOGICAL REVIEWS

Tumor Suppressor p53 Inhibits Systemic Autoimmune Diseases by Inducing Regulatory T Cells

(2013) H. Kawashima et al.   JOURNAL OF IMMUNOLOGY

STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity

(2013) Brian C. Betts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The ways and means that fine tune Sirt1 activity

(2013) Javier R. Revollo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms

(2012) U. H. Beier et al.   Science Signaling

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

(2011) M. Srinivasan et al.   BLOOD

Instability of Foxp3 Expression Limits the Ability of Induced Regulatory T Cells to Mitigate Graft versus Host Disease

(2011) A. Beres et al.   CLINICAL CANCER RESEARCH

The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

(2011) Sinyi Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin-1 Targeting Promotes Foxp3+ T-Regulatory Cell Function and Prolongs Allograft Survival

(2011) U. H. Beier et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

(2011) Jorg van Loosdregt et al.   PLoS One

Antileukemic activity of the HSP70 inhibitor pifithrin-μ in acute leukemia

(2011) M Kaiser et al.   Blood Cancer Journal

SIRT1 and p53, effect on cancer, senescence and beyond

(2010) Jingjie Yi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

(2009) T. Yi et al.   BLOOD

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

(2009) Yongzhan Nie et al.   NATURE CELL BIOLOGY

SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma

(2008) Kyu Yun Jang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The ups and downs of SIRT1

(2008) Hye-Sook Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES