PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells

Effect of CXCR4 on Apoptosis in Osteosarcoma Cells via the PI3K/Akt/NF-κβ Signaling Pathway

(2018) Chunming Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Altered CXCL12 expression reveals a dual role of CXCR4 in osteosarcoma primary tumor growth and metastasis

(2016) Olga Neklyudova et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Oncogenic and Therapeutic Targeting of PTEN Loss in Bone Malignancies

(2015) Yongming Xi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

AMD3100 reduces CXCR4-mediated survival and metastasis of osteosarcoma by inhibiting JNK and Akt, but not p38 or Erk1/2, pathways in in vitro and mouse experiments

(2015) YU-XIN LIAO et al.   ONCOLOGY REPORTS

RANKL blockade prevents and treats aggressive osteosarcomas

(2015) Yan Chen et al.   Science Translational Medicine

CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

(2014) Patrick Brennecke et al.   CLINICAL & EXPERIMENTAL METASTASIS

Novel Role for NFAT3 in ERK-Mediated Regulation of CXCR4

(2014) Keven Huang et al.   PLoS One

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

(2013) M Conley-LaComb et al.   Molecular Cancer

PTEN regulation of ERK1/2 signaling in cancer

(2012) Mahandranauth A. Chetram et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells

(2011) Mahandranauth A. Chetram et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

(2011) Alexander B Mohseny et al.   LABORATORY INVESTIGATION

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

(2010) Sam D. Molyneux et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of PTEN Permits CXCR4-Mediated Tumorigenesis through ERK1/2 in Prostate Cancer Cells

(2010) M. A. Chetram et al.   MOLECULAR CANCER RESEARCH

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

Copy number gains inEGFRand copy number losses inPTENare common events in osteosarcoma tumors

(2008) Serena S. Freeman et al.   CANCER

Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer

(2008) Takuya Akashi et al.   CANCER SCIENCE

Translating an Antagonist of Chemokine Receptor CXCR4: From Bench to Bedside

(2008) D. Wong et al.   CLINICAL CANCER RESEARCH