Glutamate and α-ketoglutarate: key players in glioma metabolism

IDH1, lipid metabolism and cancer: Shedding new light on old ideas

(2015) Elena Bogdanovic   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells

(2015) Hui Li et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

c-Myc–miR-29c–REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma

(2015) Hui Luo et al.   BRAIN

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

(2015) Xudong Fu et al.   Cell Metabolism

LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells

(2015) Xiaojuan He et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Glutaminases in brain: Multiple isoforms for many purposes

(2015) José A. Campos-Sandoval et al.   NEUROCHEMISTRY INTERNATIONAL

Metabolic consequences of oncogenic IDH mutations

(2015) Seth J. Parker et al.   PHARMACOLOGY & THERAPEUTICS

MutantIDHis sufficient to initiate enchondromatosis in mice

(2015) Makoto Hirata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS/autophagy

(2015) Huailei Liu et al.   TOXICOLOGY LETTERS

Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies

(2015) Liang Xia et al.   Oncotarget

Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

(2015) Simone Hettmer et al.   eLife

Positioning of aminopeptidase inhibitors in next generation cancer therapy

(2014) Sarina M. Hitzerd et al.   AMINO ACIDS

Glutamate/glutamine metabolism coupling between astrocytes and glioma cells: Neuroprotection and inhibition of glioma growth

(2014) Pei-Sen Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glutamate as chemotactic fuel for diffuse glioma cells: Are they glutamate suckers?

(2014) Sanne A.M. van Lith et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation

(2014) Remco J. Molenaar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

(2014) A. R. Grassian et al.   CANCER RESEARCH

Asparagine Depletion Potentiates the Cytotoxic Effect of Chemotherapy against Brain Tumors

(2014) Eduard H. Panosyan et al.   MOLECULAR CANCER RESEARCH

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

mTORC2 in the center of cancer metabolic reprogramming

(2014) Kenta Masui et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regulation of the pentose phosphate pathway by an androgen receptor–mTOR-mediated mechanism and its role in prostate cancer cell growth

(2014) E Tsouko et al.   Oncogenesis

C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells

(2013) Pin Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

(2013) Ivan Babic et al.   Cell Metabolism

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

IDHmutations: new genetic signatures in cholangiocarcinoma and therapeutic implications

(2012) Darrell R Borger et al.   Expert Review of Anticancer Therapy

Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity

(2012) Petr Busek et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ROS, autophagy, mitochondria and cancer: Ras, the hidden master?

(2012) Gregory L. Bellot et al.   MITOCHONDRION

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

(2012) Masato Sasaki et al.   NATURE

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

(2012) Janeta Popovici-Muller et al.   ACS Medicinal Chemistry Letters

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Isocitrate dehydrogenase mutations in gliomas

(2011) Changcun Guo et al.   CURRENT OPINION IN NEUROLOGY

Altered cancer cell metabolism in gliomas with mutant IDH1 or IDH2

(2011) Alexandra Borodovsky et al.   CURRENT OPINION IN ONCOLOGY

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Reductive carboxylation supports growth in tumour cells with defective mitochondria

(2011) Andrew R. Mullen et al.   NATURE

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

(2011) Hongkai Ji et al.   PLoS One

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE