Article
Materials Science, Multidisciplinary
Yanrong Qian, Fangman Chen, Man Wang, Qianqian Sun, Dan Shao, Chunxia Li
Summary: This study introduces an intelligent nanoplatform that can be triggered by near-infrared light and tumor microenvironment to achieve rapid drug release, enabling the efficient chemo-photodynamic therapy of tumors. Additionally, the nanoparticles can perform fluorescence imaging to monitor the drug delivery.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Polymer Science
Dashan Qi, Haowei Zhu, Yingjie Kong, Qingming Shen
Summary: This study combines targeted nanomedicine with injectable hydrogel for photothermal-chemotherapy combination therapy. By injecting the hydrogel precursor solution, the nanomedicine can target tumor cells and continue to release, thereby improving the accuracy and efficacy of the treatment.
Article
Chemistry, Multidisciplinary
Zhang Zhang, An Gao, Chunyang Sun
Summary: In this study, an intelligent nanocarrier capable of targeting tumor tissues and releasing drugs on demand was developed. The cascaded chemo-photodynamic therapy was achieved through light-stimulated nanocarrier disassembly and drug release.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li, Feilong Deng
Summary: Treatment for chronic diabetic wounds remains a clinical challenge. A multifunctional hydrogel with two-stage sequential release upon NIR stimulation, antibacterial activity and pro-angiogenic efficacy has been developed. This hydrogel consists of covalently crosslinked bilayer structure with peptide-functionalized gold nanorods embedded in each layer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Qianli Li, Yi Hou, Pinyin Cao, Ruiye Bi, Songsong Zhu
Summary: A novel near-infrared light-sensitive drug delivery system was developed for the treatment of temporomandibular joint osteoarthritis. The system exhibited excellent photothermal effect and controlled drug release through laser irradiation, showing potential for multifunctional therapeutic effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Yutao Cao, Kaiqi Wang, Pengyu Zhu, Xianwen Zou, Guiqi Ma, Wenxian Zhang, Diqing Wang, Jipeng Wan, Yanling Ma, Xiao Sun, Jian Dong
Summary: The combination of MoS2 quantum dots and doxorubicin in a core/shell nano-photosensitizer shows promising potential for up-converted luminescence imaging guided chemo-photodynamic synergistic therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Lijie Huang, Junjie Wang, Lili Kong, Xing Wang, Qiulei Li, Lingjiao Zhang, Jingru Shi, Jinyou Duan, Haibo Mu
Summary: Probiotics are commonly used in inflammatory bowel disease, but their effectiveness is limited by low survival rate and short retention time. To address this issue, researchers developed a ROS-responsive hydrogel based on hyaluronic acid for encapsulation and targeted delivery of probiotics. The hydrogel improved the survival rate of encapsulated probiotics in simulated digestive conditions and selectively released them at inflammation sites. Animal experiments showed that hydrogel-encapsulated probiotics significantly alleviated symptoms and improved survival rate in mice with colitis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Kaiqing Yun, Juntong Guo, Renfang Zhu, Tianyi Wang, Xiaoyan Zhang, Hao Pan, Weisan Pan
Summary: This article describes the development of a ROS-responsive nanoparticle that can overcome the limitations of chemotherapy and photothermal therapy. By integrating a photothermal agent into the nanoparticle, it shows high photothermal performance and remarkable tumor-targeting ability, enabling accurate drug delivery and achieving excellent chemo-photothermal treatment effect.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Shihui Ding, Wenbo Wu, Tingting Peng, Wen Pang, Pengfei Jiang, Qiuqiang Zhan, Shuhong Qi, Xunbin Wei, Bobo Gu, Bin Liu
Summary: The study introduced a NIR light excitable UCNP@TBD nanocomposite, which combines TBD with UCNP and exhibits good photostability, biocompatibility, and ROS generation efficiency under NIR light excitation for improved anticancer therapeutic outcomes.
NANOSCALE ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Maomao He, Guangli He, Peiyuan Wang, Suhua Jiang, Ziyue Jiao, Dongmei Xi, Pengcheng Miao, Xuefei Leng, Zhiyong Wei, Yang Li, Yanjun Yang, Ran Wang, Jianjun Du, Jiangli Fan, Wen Sun, Xiaojun Peng
Summary: A red-light-activatable metallopolymer, Poly(Ru/PTX), is synthesized for combined chemo-photodynamic therapy. The polymer self-assembles into nanoparticles, efficiently accumulating at tumor sites, and synchronously releasing the therapeutics to achieve synergistic antitumoral effects.
Article
Engineering, Biomedical
Man Shu, Junjie Tang, Lili Chen, Qiang Zeng, Chao Li, Shuting Xiao, Zhaozhong Jiang, Jie Liu
Summary: A novel combined chemo/photodynamic therapy has been developed using pH/ROS/MMP-2 triple-responsive drug nanocarriers for efficient treatment of solid tumors. The nanoparticles can effectively accumulate in tumors, release drugs in response to intracellular pH and ROS levels, and amplify ROS generation with external laser irradiation to achieve extraordinary therapeutic efficacy. The treatment showed substantial tumor shrinkage and eradication with low toxicity in major organs, indicating great potential for tumor therapy.
Article
Materials Science, Multidisciplinary
Yuting Gao, Jiaxin Zhang, Zhenyan He, Liang Luo, Chunjie Yan
Summary: The study combined cisplatin into an AIE-based photosensitizer to create BT-Pt, which demonstrated highly efficient antitumor drug properties and favorable therapeutic efficacy for HeLa cells.
ORGANIC ELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Zhuo Wan, Xueqi Gan, Ruiyan Mei, Jianbin Du, Wen Fan, Mengying Wei, Guodong Yang, Weiwei Qin, Zhuoli Zhu, Li Liu
Summary: The study successfully constructed mPEG2000-TK-CP05 decorated exosomes as effective delivery platforms to enhance photodynamic/chemical cancer therapy, while reducing drug dosage and promoting tumor immune response. The proposed switchable stealth exosomes serve as a promising and powerful drug delivery nanoplatform in cancer treatment.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
De-Chao Yang, Shuai Wang, Xiao-Lu Weng, Hong-Xia Zhang, Jian-Yong Liu, Zhonghui Lin
Summary: A smart nanocarrier, named singlet oxygen-responsive nanoparticle (SOR-NP), was developed by introducing singlet oxygen-sensitive aminoacrylate linkers into copolymers for light-controlled drug release and combination cancer treatment. The nanocarrier successfully relieved the aggregation of encapsulated photosensitizers, resulting in bright fluorescent signals and high levels of reactive oxygen species for mediating cell death via photodynamic therapy. The light-triggered drug release and combined anticancer effects were validated in cancer cells and tumor-bearing mice, offering a promising strategy for tumor-specific drug release and selective photodynamic-chemo combination treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Jiaqi He, Guoqin Chen, Peng Zhao, Caiwen Ou
Summary: A smart synergetic delivery system using black phosphorus hybrid polypeptides hydrogel loaded with bufalin achieved NIR-controllable drug release, reducing side effects of bufalin and efficiently eliminating tumors in vivo with good biosafety and biocompatibility.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)